Emerging Modulators of TMEM16A and Their Therapeutic Potential

• Published in: The Journal of membrane biology Vol. 254; no. 4; pp. 353 - 365
• Main Authors: Hao, Anqi, Guo, Shuai, Shi, Sai, Wang, Xuzhao, Zhan, Yong, Chen, Yafei, An, Hailong
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2021; Springer Nature B.V
• Subjects: Anoctamin-1 - genetics; Asthma; Biochemistry; Biomedical and Life Sciences; Calcium - metabolism; Calcium channels; Calcium chloride; Cancer; Chloride channels (calcium-gated); Chloride Channels - genetics; Chloride ions; Excitability; Fertilization; Gastric motility; Gastrointestinal Motility; Human Physiology; Ion channels; Life Sciences; Modulators; Motility; Muscle contraction; Muscles; Muscular function; Neuromodulation; Physiology; Smooth muscle; Therapeutic targets; Topical Review; Efficacy; TMEM16A/ANO1; Modulators; Screening methods; Diseases

Calcium-activated chloride channels (CaCCs) are widespread chloride channels which rely on calcium activation to perform their functions. In 2008, TMEM16A (also known as anoctamin1, ANO1) was identified as the molecular basis of the CaCCs, which provided the possibility to study the physiological fu...