Emerging Modulators of TMEM16A and Their Therapeutic Potential

Calcium-activated chloride channels (CaCCs) are widespread chloride channels which rely on calcium activation to perform their functions. In 2008, TMEM16A (also known as anoctamin1, ANO1) was identified as the molecular basis of the CaCCs, which provided the possibility to study the physiological fu...

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Published inThe Journal of membrane biology Vol. 254; no. 4; pp. 353 - 365
Main Authors Hao, Anqi, Guo, Shuai, Shi, Sai, Wang, Xuzhao, Zhan, Yong, Chen, Yafei, An, Hailong
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2021
Springer Nature B.V
Subjects
Anoctamin-1 - genetics
Asthma
Biochemistry
Biomedical and Life Sciences
Calcium - metabolism
Calcium channels
Calcium chloride
Cancer
Chloride channels (calcium-gated)
Chloride Channels - genetics
Chloride ions
Excitability
Fertilization
Gastric motility
Gastrointestinal Motility
Human Physiology
Ion channels
Life Sciences
Modulators
Motility
Muscle contraction
Muscles
Muscular function
Neuromodulation
Physiology
Smooth muscle
Therapeutic targets
Topical Review
Efficacy
TMEM16A/ANO1
Modulators
Screening methods
Diseases
Online AccessGet full text

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Abstract Calcium-activated chloride channels (CaCCs) are widespread chloride channels which rely on calcium activation to perform their functions. In 2008, TMEM16A (also known as anoctamin1, ANO1) was identified as the molecular basis of the CaCCs, which provided the possibility to study the physiological function of CaCCs. TMEM16A is widely expressed in various cells and controls basic physiological functions, including neuronal and cardiac excitability, nerve transduction, smooth muscle contraction, epithelial Cl − secretion and fertilization. However, the abnormal function of TMEM16A may cause a variety of diseases, including asthma, gastrointestinal motility disorder and various cancers. Therefore, TMEM16A is a putative drug target for many diseases, and it is important to determine specific and efficient modulators of TMEM16A channel. In recent years, we and others have screened several natural modulators of TMEM16A against cancers and gastrointestinal motility dysfunction. This article reviews the screening methods, efficacy of TMEM16A modulators and pharmacological effects of TMEM16A modulators on different diseases. Graphic Abstact
AbstractList Calcium-activated chloride channels (CaCCs) are widespread chloride channels which rely on calcium activation to perform their functions. In 2008, TMEM16A (also known as anoctamin1, ANO1) was identified as the molecular basis of the CaCCs, which provided the possibility to study the physiological function of CaCCs. TMEM16A is widely expressed in various cells and controls basic physiological functions, including neuronal and cardiac excitability, nerve transduction, smooth muscle contraction, epithelial Cl- secretion and fertilization. However, the abnormal function of TMEM16A may cause a variety of diseases, including asthma, gastrointestinal motility disorder and various cancers. Therefore, TMEM16A is a putative drug target for many diseases, and it is important to determine specific and efficient modulators of TMEM16A channel. In recent years, we and others have screened several natural modulators of TMEM16A against cancers and gastrointestinal motility dysfunction. This article reviews the screening methods, efficacy of TMEM16A modulators and pharmacological effects of TMEM16A modulators on different diseases. GRAPHIC ABSTACT.Calcium-activated chloride channels (CaCCs) are widespread chloride channels which rely on calcium activation to perform their functions. In 2008, TMEM16A (also known as anoctamin1, ANO1) was identified as the molecular basis of the CaCCs, which provided the possibility to study the physiological function of CaCCs. TMEM16A is widely expressed in various cells and controls basic physiological functions, including neuronal and cardiac excitability, nerve transduction, smooth muscle contraction, epithelial Cl- secretion and fertilization. However, the abnormal function of TMEM16A may cause a variety of diseases, including asthma, gastrointestinal motility disorder and various cancers. Therefore, TMEM16A is a putative drug target for many diseases, and it is important to determine specific and efficient modulators of TMEM16A channel. In recent years, we and others have screened several natural modulators of TMEM16A against cancers and gastrointestinal motility dysfunction. This article reviews the screening methods, efficacy of TMEM16A modulators and pharmacological effects of TMEM16A modulators on different diseases. GRAPHIC ABSTACT.
Calcium-activated chloride channels (CaCCs) are widespread chloride channels which rely on calcium activation to perform their functions. In 2008, TMEM16A (also known as anoctamin1, ANO1) was identified as the molecular basis of the CaCCs, which provided the possibility to study the physiological function of CaCCs. TMEM16A is widely expressed in various cells and controls basic physiological functions, including neuronal and cardiac excitability, nerve transduction, smooth muscle contraction, epithelial Cl − secretion and fertilization. However, the abnormal function of TMEM16A may cause a variety of diseases, including asthma, gastrointestinal motility disorder and various cancers. Therefore, TMEM16A is a putative drug target for many diseases, and it is important to determine specific and efficient modulators of TMEM16A channel. In recent years, we and others have screened several natural modulators of TMEM16A against cancers and gastrointestinal motility dysfunction. This article reviews the screening methods, efficacy of TMEM16A modulators and pharmacological effects of TMEM16A modulators on different diseases. Graphic Abstact
Calcium-activated chloride channels (CaCCs) are widespread chloride channels which rely on calcium activation to perform their functions. In 2008, TMEM16A (also known as anoctamin1, ANO1) was identified as the molecular basis of the CaCCs, which provided the possibility to study the physiological function of CaCCs. TMEM16A is widely expressed in various cells and controls basic physiological functions, including neuronal and cardiac excitability, nerve transduction, smooth muscle contraction, epithelial Cl secretion and fertilization. However, the abnormal function of TMEM16A may cause a variety of diseases, including asthma, gastrointestinal motility disorder and various cancers. Therefore, TMEM16A is a putative drug target for many diseases, and it is important to determine specific and efficient modulators of TMEM16A channel. In recent years, we and others have screened several natural modulators of TMEM16A against cancers and gastrointestinal motility dysfunction. This article reviews the screening methods, efficacy of TMEM16A modulators and pharmacological effects of TMEM16A modulators on different diseases. GRAPHIC ABSTACT.
Calcium-activated chloride channels (CaCCs) are widespread chloride channels which rely on calcium activation to perform their functions. In 2008, TMEM16A (also known as anoctamin1, ANO1) was identified as the molecular basis of the CaCCs, which provided the possibility to study the physiological function of CaCCs. TMEM16A is widely expressed in various cells and controls basic physiological functions, including neuronal and cardiac excitability, nerve transduction, smooth muscle contraction, epithelial Cl− secretion and fertilization. However, the abnormal function of TMEM16A may cause a variety of diseases, including asthma, gastrointestinal motility disorder and various cancers. Therefore, TMEM16A is a putative drug target for many diseases, and it is important to determine specific and efficient modulators of TMEM16A channel. In recent years, we and others have screened several natural modulators of TMEM16A against cancers and gastrointestinal motility dysfunction. This article reviews the screening methods, efficacy of TMEM16A modulators and pharmacological effects of TMEM16A modulators on different diseases.Graphic Abstact
Author Shi, Sai
Chen, Yafei
An, Hailong
Hao, Anqi
Guo, Shuai
Wang, Xuzhao
Zhan, Yong
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  organization: Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, School of Electrical Engineering, Hebei University of Technology
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Cites_doi 10.1007/s00232-017-9975-9
10.1586/egh.11.87
10.1038/nature07313
10.1172/jci.insight.128414
10.1016/j.phrs.2020.104721
10.1371/journal.pone.0174935
10.1016/j.ejmech.2018.10.002
10.1371/journal.pone.0038030
10.3389/fphar.2016.00270
10.1007/s00216-013-7550-5
10.3390/ijms19103204
10.1172/JCI41084
10.1111/bph.13841
10.2174/157340911793743547
10.1074/jbc.M110.175109
10.1074/jbc.275.9.6047
10.3109/14756366.2015.1135912
10.1016/j.jtbi.2014.04.004
10.1113/jphysiol.1983.sp014852
10.1096/fj.202000443RR
10.1002/jcp.27529
10.1038/nrdp.2015.10
10.1016/j.csbj.2020.03.015
10.1038/nature25024
10.1007/s00424-014-1572-5
10.1038/nature24652
10.1371/journal.pone.0043265
10.1007/s00424-016-1830-9
10.1371/journal.pone.0133656
10.1164/rccm.201908-1641OC
10.1016/s0014-5793(01)02561-3
10.1016/j.phrs.2020.104763
10.1111/j.1476-5381.2012.02199.x
10.3345/kjp.2014.57.1.1
10.1111/bph.13077
10.1038/nature13984
10.1074/jbc.M110.196089
10.1124/mol.107.043208
10.1021/acs.jmedchem.7b00020
10.3389/fphar.2019.00003
10.1016/j.cell.2008.09.003
10.1089/adt.2019.962
10.1126/science.1163518
10.1038/nrd2780
10.1159/000374043
10.1016/j.bpj.2019.11.015
10.1096/fj.11-191627
10.1186/s12990-015-0061-y
10.1007/s00424-016-1790-0
10.1371/journal.pone.0144715
10.1371/journal.pone.0155771
10.1039/c9np00056a
10.1124/mol.113.087502
10.1186/s13046-017-0499-z
10.1002/jcp.27865
10.1016/j.yjmcc.2015.02.020
10.1038/srep16657
10.1016/j.phrs.2019.104323
10.1073/pnas.1217072110
10.1016/j.jcf.2004.05.025
10.1124/mol.109.061051
10.1096/fj.10-160648
10.3389/fphar.2019.00051
10.1016/j.juro.2013.02.107
10.1007/s00424-017-1934-x
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IEDL.DBID U2A
ISSN 0022-2631
1432-1424
IngestDate Wed Jul 30 11:15:11 EDT 2025
Wed Aug 13 08:56:50 EDT 2025
Wed Feb 19 02:25:46 EST 2025
Thu Apr 24 23:03:29 EDT 2025
Tue Jul 01 02:08:41 EDT 2025
Fri Feb 21 02:47:59 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords Efficacy
TMEM16A/ANO1
Modulators
Screening methods
Diseases
Language English
License 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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PublicationTitle The Journal of membrane biology
PublicationTitleAbbrev J Membrane Biol
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Publisher Springer US
Springer Nature B.V
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References Cao, Liu, Ji (CR9) 2017
Verkman, Galietta (CR62) 2009; 8
Oh, Jung (CR45) 2016; 468
Schroeder, Cheng, Jan (CR53) 2008; 134
Bajaj, Ong, Chandy (CR3) 2020; 37
Seo, Ryu, Park (CR56) 2017; 12
Acharya, Coop, Polli (CR1) 2011; 7
Guo, Chen, Shi (CR25) 2020; 155
Seo, Lee, Park (CR55) 2016; 11
Zhang, Chen, An (CR66) 2014; 355
Ji, Guo, Wang (CR29) 2019; 234
Namkung, Thiagarajah, Phuan (CR41) 2010; 24
Chai, Chen, Yuan (CR11) 2017; 250
Lee, Yi (CR36) 2018; 19
Wang, Li, Huai (CR63) 2015; 82
Contreras-Vite, Cruz-Rangel, De Jesús-Pérez (CR12) 2016; 468
Jayaraman, Haggie, Wachter (CR28) 2000; 275
Cabrita, Benedetto, Schreiber (CR8) 2019; 4
Ruiz, Martins, Rudin (CR52) 2012; 7
Tradtrantip, Namkung, Verkman (CR60) 2010; 77
Sui, Wu, Lv (CR59) 2015; 10
Danahay, Lilley, Fox (CR14) 2020; 201
Miner, Labitzke, Liu (CR40) 2019; 10
Mazzone, Bernard, Strege (CR39) 2011; 286
Qi, Wang, Liu (CR50) 2014; 406
Ji, Shi, Guo (CR30) 2020; 34
Caputo, Caci, Ferrera (CR10) 2008; 322
Gim, Nam, Lee (CR21) 2015; 35
Davis, Shi, Pritchard (CR16) 2013; 168
Namkung, Yao, Finkbeiner (CR43) 2011; 25
Dixit, Kemp, Kulich (CR19) 2015; 5
Katoh, Katoh (CR33) 2003; 22
Oh, Hwang, Jung (CR46) 2013; 84
Truong, Phuan, Reggi (CR61) 2017; 60
Barish (CR4) 1983; 342
Henckels, Fong, Phillips (CR27) 2020; 18
Cottreau, Tucker, Crutchley (CR13) 2012; 6
Seo, Park, Kim (CR54) 2015; 10
Burris, Wang, Bulley (CR7) 2015; 172
De La Fuente, Namkung, Mills (CR17) 2008; 73
Seo, Kim, Chang (CR57) 2018; 160
Guo, Chen, Shi (CR26) 2020; 118
Deba, Bessac (CR18) 2015
Ratjen, Bell, Rowe (CR51) 2015; 1
Guo, Wang, Pang (CR24) 2019; 146
Yao, Namkung, Ko (CR65) 2012; 7
Liu, Linley, Du (CR37) 2010; 120
Norez, Heda, Jensen (CR44) 2004; 3
Namkung, Phuan, Verkman (CR42) 2011; 286
Kim (CR34) 2014; 57
Kunzelmann, Ousingsawat, Cabrita (CR35) 2019; 10
Jiang, Yu, Yang (CR31) 2016; 7
Dang, Feng, Tien (CR15) 2017; 552
Paulino, Kalienkova, Lam (CR47) 2017; 552
Zhang, Zhang, Zhai (CR68) 2020; 156
Yang, Cho, Koo (CR64) 2008; 455
CR22
Britschgi, Bill, Brinkhaus (CR5) 2013; 110
Atala (CR2) 2013; 189
Brunner, Lim, Schenck (CR6) 2014; 516
Shi, Pang, Guo (CR58) 2020; 18
Guo, Chen, Pang (CR23) 2019; 234
Piechowicz, Truong, Javed (CR49) 2016; 31
Galietta, Haggie, Verkman (CR20) 2001; 499
Liu, Zhang, Huang (CR38) 2015; 467
Zhang, Li, Zhang (CR67) 2017; 174
S Bajaj (188_CR3) 2020; 37
S Dang (188_CR15) 2017; 552
Q Ji (188_CR30) 2020; 34
L Tradtrantip (188_CR60) 2010; 77
R Dixit (188_CR19) 2015; 5
HL Danahay (188_CR14) 2020; 201
S Guo (188_CR24) 2019; 146
Y Seo (188_CR55) 2016; 11
YD Yang (188_CR64) 2008; 455
A Britschgi (188_CR5) 2013; 110
C Acharya (188_CR1) 2011; 7
A Caputo (188_CR10) 2008; 322
Q Cao (188_CR9) 2017
KA Henckels (188_CR27) 2020; 18
188_CR22
AS Verkman (188_CR62) 2009; 8
R De La Fuente (188_CR17) 2008; 73
C Ruiz (188_CR52) 2012; 7
ME Barish (188_CR4) 1983; 342
Y Sui (188_CR59) 2015; 10
S Guo (188_CR25) 2020; 155
JB Kim (188_CR34) 2014; 57
B Liu (188_CR37) 2010; 120
K Kunzelmann (188_CR35) 2019; 10
Z Yao (188_CR65) 2012; 7
SJ Oh (188_CR46) 2013; 84
Y Seo (188_CR54) 2015; 10
C Paulino (188_CR47) 2017; 552
S Jayaraman (188_CR28) 2000; 275
Y Seo (188_CR57) 2018; 160
K Miner (188_CR40) 2019; 10
J Qi (188_CR50) 2014; 406
LJ Galietta (188_CR20) 2001; 499
SK Burris (188_CR7) 2015; 172
A Mazzone (188_CR39) 2011; 286
C Norez (188_CR44) 2004; 3
EC Truong (188_CR61) 2017; 60
KA Piechowicz (188_CR49) 2016; 31
Y Jiang (188_CR31) 2016; 7
W Namkung (188_CR43) 2011; 25
X Zhang (188_CR67) 2017; 174
Y Seo (188_CR56) 2017; 12
J Cottreau (188_CR13) 2012; 6
Y Liu (188_CR38) 2015; 467
R Chai (188_CR11) 2017; 250
S Zhang (188_CR66) 2014; 355
M Katoh (188_CR33) 2003; 22
A Atala (188_CR2) 2013; 189
AJ Davis (188_CR16) 2013; 168
BC Schroeder (188_CR53) 2008; 134
H Gim (188_CR21) 2015; 35
JA Contreras-Vite (188_CR12) 2016; 468
S Guo (188_CR26) 2020; 118
I Cabrita (188_CR8) 2019; 4
Q Ji (188_CR29) 2019; 234
S Shi (188_CR58) 2020; 18
U Oh (188_CR45) 2016; 468
YH Lee (188_CR36) 2018; 19
B Wang (188_CR63) 2015; 82
X Zhang (188_CR68) 2020; 156
JD Brunner (188_CR6) 2014; 516
F Ratjen (188_CR51) 2015; 1
F Deba (188_CR18) 2015
S Guo (188_CR23) 2019; 234
W Namkung (188_CR41) 2010; 24
W Namkung (188_CR42) 2011; 286
References_xml – volume: 250
  start-page: 483
  issue: 5
  year: 2017
  end-page: 492
  ident: CR11
  article-title: Identification of resveratrol, an herbal compound, as an activator of the calcium-activated chloride channel, TMEM16A
  publication-title: J Membr Biol
  doi: 10.1007/s00232-017-9975-9
– ident: CR22
– volume: 6
  start-page: 17
  issue: 1
  year: 2012
  end-page: 23
  ident: CR13
  article-title: Crofelemer for the treatment of secretory diarrhea
  publication-title: Expert Rev Gastroenterol Hepatol
  doi: 10.1586/egh.11.87
– volume: 455
  start-page: 1210
  issue: 7217
  year: 2008
  end-page: 1215
  ident: CR64
  article-title: TMEM16A confers receptor-activated calcium-dependent chloride conductance
  publication-title: Nature
  doi: 10.1038/nature07313
– volume: 4
  issue: 15
  year: 2019
  ident: CR8
  article-title: Niclosamide repurposed for the treatment of inflammatory airway disease
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.128414
– volume: 155
  year: 2020
  ident: CR25
  article-title: Arctigenin, a novel TMEM16A inhibitor for lung adenocarcinoma therapy
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2020.104721
– volume: 12
  issue: 3
  year: 2017
  ident: CR56
  article-title: Inhibition of ANO1 by luteolin and its cytotoxicity in human prostate cancer PC-3 cells
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0174935
– volume: 160
  start-page: 245
  year: 2018
  end-page: 255
  ident: CR57
  article-title: Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors
  publication-title: Eur J Med Chem
  doi: 10.1016/j.ejmech.2018.10.002
– volume: 7
  start-page: e38030
  issue: 5
  year: 2012
  ident: CR65
  article-title: Fractionation of a herbal antidiarrheal medicine reveals eugenol as an inhibitor of Ca -Activated Cl channel TMEM16A
  publication-title: PloS One
  doi: 10.1371/journal.pone.0038030
– volume: 7
  start-page: 270
  year: 2016
  ident: CR31
  article-title: Shikonin inhibits intestinal calcium-activated chloride channels and prevents rotaviral diarrhea
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2016.00270
– volume: 406
  start-page: 1713
  issue: 6
  year: 2014
  end-page: 1721
  ident: CR50
  article-title: Development and validation of HTS assay for screening the calcium-activated chloride channel modulators in TMEM16A stably expressed CHO cells
  publication-title: Anal Bioanal Chem
  doi: 10.1007/s00216-013-7550-5
– volume: 19
  start-page: 3204
  issue: 10
  year: 2018
  ident: CR36
  article-title: Prediction of novel anoctamin1 (ANO1) inhibitors using 3D-QSAR pharmacophore modeling and molecular docking
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms19103204
– volume: 120
  start-page: 1240
  issue: 4
  year: 2010
  end-page: 1252
  ident: CR37
  article-title: The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K channels and activation of Ca -activated Cl channels
  publication-title: J Clin Investig
  doi: 10.1172/JCI41084
– volume: 174
  start-page: 2334
  issue: 14
  year: 2017
  end-page: 2345
  ident: CR67
  article-title: Inhibition of transmembrane member 16A calcium-activated chloride channels by natural flavonoids contributes to flavonoid anticancer effects
  publication-title: Br J Pharmacol
  doi: 10.1111/bph.13841
– volume: 7
  start-page: 10
  issue: 1
  year: 2011
  end-page: 22
  ident: CR1
  article-title: Recent advances in ligand-based drug design: relevance and utility of the conformationally sampled pharmacophore approach
  publication-title: Curr Comput Aided Drug Des
  doi: 10.2174/157340911793743547
– volume: 286
  start-page: 2365
  issue: 3
  year: 2011
  end-page: 2374
  ident: CR42
  article-title: TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M110.175109
– volume: 275
  start-page: 6047
  issue: 9
  year: 2000
  end-page: 6050
  ident: CR28
  article-title: Mechanism and cellular applications of a green fluorescent protein-based halide sensor
  publication-title: J Biol Chem
  doi: 10.1074/jbc.275.9.6047
– volume: 31
  start-page: 1362
  issue: 6
  year: 2016
  end-page: 1368
  ident: CR49
  article-title: Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1
  publication-title: J Enzyme Inhib Med Chem
  doi: 10.3109/14756366.2015.1135912
– volume: 355
  start-page: 229
  year: 2014
  end-page: 235
  ident: CR66
  article-title: A novel biophysical model on calcium and voltage dual dependent gating of calcium-activated chloride channel
  publication-title: J Theor Biol
  doi: 10.1016/j.jtbi.2014.04.004
– volume: 342
  start-page: 309
  year: 1983
  end-page: 325
  ident: CR4
  article-title: A transient calcium-dependent chloride current in the immature Xenopus oocyte
  publication-title: J Physiol
  doi: 10.1113/jphysiol.1983.sp014852
– volume: 34
  start-page: 13430
  issue: 10
  year: 2020
  end-page: 13444
  ident: CR30
  article-title: Activation of TMEM16A by natural product canthaxanthin promotes gastrointestinal contraction
  publication-title: FASEB J
  doi: 10.1096/fj.202000443RR
– volume: 234
  start-page: 8698
  issue: 6
  year: 2019
  end-page: 8708
  ident: CR23
  article-title: Matrine is a novel inhibitor of the TMEM16A chloride channel with antilung adenocarcinoma effects
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.27529
– volume: 1
  start-page: 15010
  year: 2015
  ident: CR51
  publication-title: Cyst Fibros Nature Rev Dis Primers
  doi: 10.1038/nrdp.2015.10
– volume: 18
  start-page: 714
  year: 2020
  end-page: 722
  ident: CR58
  article-title: Recent progress in structural studies on TMEM16A channel
  publication-title: Comput Struct Biotechnol J
  doi: 10.1016/j.csbj.2020.03.015
– volume: 552
  start-page: 426
  issue: 7685
  year: 2017
  end-page: 429
  ident: CR15
  article-title: Cryo-EM structures of the TMEM16A calcium-activated chloride channel
  publication-title: Nature
  doi: 10.1038/nature25024
– volume: 467
  start-page: 1417
  issue: 7
  year: 2015
  end-page: 1430
  ident: CR38
  article-title: Characterization of the effects of Cl channel modulators on TMEM16A and bestrophin-1 Ca activated Cl channels
  publication-title: Pflugers Arch
  doi: 10.1007/s00424-014-1572-5
– volume: 552
  start-page: 421
  issue: 7685
  year: 2017
  end-page: 425
  ident: CR47
  article-title: Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM
  publication-title: Nature
  doi: 10.1038/nature24652
– volume: 7
  start-page: e43265
  issue: 8
  year: 2012
  ident: CR52
  article-title: Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis
  publication-title: PloSOne
  doi: 10.1371/journal.pone.0043265
– volume: 468
  start-page: 1241
  issue: 7
  year: 2016
  end-page: 1257
  ident: CR12
  article-title: Revealing the activation pathway for TMEM16A chloride channels from macroscopic currents and kinetic models
  publication-title: Pflugers Arch
  doi: 10.1007/s00424-016-1830-9
– volume: 10
  issue: 7
  year: 2015
  ident: CR54
  article-title: Inhibition of ANO1/TMEM16A chloride channel by idebenone and its cytotoxicity to cancer cell lines
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0133656
– volume: 201
  start-page: 946
  issue: 8
  year: 2020
  end-page: 954
  ident: CR14
  article-title: TMEM16A potentiation: a novel therapeutic approach for the treatment of cystic fibrosis
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201908-1641OC
– volume: 499
  start-page: 220
  issue: 3
  year: 2001
  end-page: 224
  ident: CR20
  article-title: Green fluorescent protein-based halide indicators with improved chloride and iodide affinities
  publication-title: FEBS Lett
  doi: 10.1016/s0014-5793(01)02561-3
– volume: 156
  year: 2020
  ident: CR68
  article-title: Inhibition of TMEM16A Ca -activated Cl channels by avermectins is essential for their anticancer effects
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2020.104763
– volume: 168
  start-page: 773
  issue: 3
  year: 2013
  end-page: 784
  ident: CR16
  article-title: Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh)-A01
  publication-title: Br J Pharmacol
  doi: 10.1111/j.1476-5381.2012.02199.x
– volume: 57
  start-page: 1
  issue: 1
  year: 2014
  end-page: 18
  ident: CR34
  article-title: Channelopathies. Korean
  publication-title: J Pediatr
  doi: 10.3345/kjp.2014.57.1.1
– volume: 172
  start-page: 2459
  issue: 10
  year: 2015
  end-page: 2468
  ident: CR7
  article-title: 9-Phenanthrol inhibits recombinant and arterial myocyte TMEM16A channels
  publication-title: Br J Pharmacol
  doi: 10.1111/bph.13077
– volume: 516
  start-page: 207
  issue: 7530
  year: 2014
  end-page: 212
  ident: CR6
  article-title: X-ray structure of a calcium-activated TMEM16 lipid scramblase
  publication-title: Nature
  doi: 10.1038/nature13984
– volume: 286
  start-page: 13393
  issue: 15
  year: 2011
  end-page: 13403
  ident: CR39
  article-title: Altered expression of Ano1 variants in human diabetic gastroparesis
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M110.196089
– volume: 73
  start-page: 758
  issue: 3
  year: 2008
  end-page: 768
  ident: CR17
  article-title: Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.107.043208
– volume: 60
  start-page: 4626
  issue: 11
  year: 2017
  end-page: 4635
  ident: CR61
  article-title: Substituted 2-acylaminocycloalkylthiophene-3-carboxylic acid arylamides as inhibitors of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A)
  publication-title: J Med Chem
  doi: 10.1021/acs.jmedchem.7b00020
– volume: 10
  start-page: 3
  year: 2019
  ident: CR35
  article-title: TMEM16A in Cystic Fibrosis: activating or inhibiting?
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2019.00003
– volume: 134
  start-page: 1019
  issue: 6
  year: 2008
  end-page: 1029
  ident: CR53
  article-title: Expression cloning of TMEM16A as a calcium-activated chloride channel subunit
  publication-title: Cell
  doi: 10.1016/j.cell.2008.09.003
– volume: 18
  start-page: 134
  issue: 3
  year: 2020
  end-page: 147
  ident: CR27
  article-title: Development of a QPatch-Automated Electrophysiology Assay for Identifying TMEM16A Small-Molecule Inhibitors
  publication-title: Assay Drug Dev Technol
  doi: 10.1089/adt.2019.962
– volume: 322
  start-page: 590
  issue: 5901
  year: 2008
  end-page: 594
  ident: CR10
  article-title: TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity
  publication-title: Science (NY)
  doi: 10.1126/science.1163518
– volume: 8
  start-page: 153
  issue: 2
  year: 2009
  end-page: 171
  ident: CR62
  article-title: Chloride channels as drug targets
  publication-title: Nat Rev Drug Discovery
  doi: 10.1038/nrd2780
– volume: 22
  start-page: 1375
  issue: 6
  year: 2003
  end-page: 1381
  ident: CR33
  article-title: FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products
  publication-title: Int J Oncol
– volume: 35
  start-page: 2422
  issue: 6
  year: 2015
  end-page: 2436
  ident: CR21
  article-title: Quercetin Inhibits Pacemaker Potentials via Nitric Oxide/cGMP-Dependent Activation and TRPM7/ANO1 Channels in Cultured Interstitial Cells of Cajal from Mouse Small Intestine
  publication-title: Cell Physiol Biochem: Int J Exp Cell Physiol, Biochem, Pharmacol
  doi: 10.1159/000374043
– volume: 118
  start-page: 262
  issue: 1
  year: 2020
  end-page: 272
  ident: CR26
  article-title: The molecular mechanism of ginsenoside analogs activating TMEM16A
  publication-title: Biophys J
  doi: 10.1016/j.bpj.2019.11.015
– volume: 25
  start-page: 4048
  issue: 11
  year: 2011
  end-page: 4062
  ident: CR43
  article-title: Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction
  publication-title: FASEB J : Off Publ Fed Am Soc Exp Biol
  doi: 10.1096/fj.11-191627
– year: 2015
  ident: CR18
  article-title: Anoctamin-1 Cl(-) channels in nociception: activation by an N-aroylaminothiazole and capsaicin and inhibition by T16A[inh]-A01
  publication-title: Molecular Pain
  doi: 10.1186/s12990-015-0061-y
– volume: 468
  start-page: 443
  issue: 3
  year: 2016
  end-page: 453
  ident: CR45
  article-title: Cellular functions of TMEM16/anoctamin
  publication-title: Pflugers Arch
  doi: 10.1007/s00424-016-1790-0
– volume: 10
  issue: 12
  year: 2015
  ident: CR59
  article-title: Identification of the novel TMEM16A inhibitor dehydroandrographolide and its anticancer activity on SW620 cells
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0144715
– volume: 11
  issue: 5
  year: 2016
  ident: CR55
  article-title: Ani9, a novel potent small-molecule ano1 inhibitor with negligible effect on ANO2
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0155771
– volume: 37
  start-page: 703
  issue: 5
  year: 2020
  end-page: 716
  ident: CR3
  article-title: Contributions of natural products to ion channel pharmacology
  publication-title: Nat Prod Rep
  doi: 10.1039/c9np00056a
– volume: 84
  start-page: 726
  issue: 5
  year: 2013
  end-page: 735
  ident: CR46
  article-title: MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.113.087502
– year: 2017
  ident: CR9
  article-title: MicroRNA-381 inhibits the metastasis of gastric cancer by targeting TMEM16A expression
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/s13046-017-0499-z
– volume: 234
  start-page: 7856
  issue: 6
  year: 2019
  end-page: 7873
  ident: CR29
  article-title: Recent advances in TMEM16A: structure, function, and disease
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.27865
– volume: 82
  start-page: 22
  year: 2015
  end-page: 32
  ident: CR63
  article-title: Overexpression of ANO1/TMEM16A, an arterial Ca -activated Cl channel, contributes to spontaneous hypertension
  publication-title: J Mol Cell Cardiol
  doi: 10.1016/j.yjmcc.2015.02.020
– volume: 5
  start-page: 16657
  year: 2015
  ident: CR19
  article-title: TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation
  publication-title: Sci Rep
  doi: 10.1038/srep16657
– volume: 146
  year: 2019
  ident: CR24
  article-title: Entering the spotlight: Chitosan oligosaccharides as novel activators of CaCCs/TMEM16A
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2019.104323
– volume: 110
  start-page: E1026
  issue: 11
  year: 2013
  end-page: E1034
  ident: CR5
  article-title: Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1217072110
– volume: 3
  start-page: 119
  issue: Suppl 2
  year: 2004
  end-page: 121
  ident: CR44
  article-title: Determination of CFTR chloride channel activity and pharmacology using radiotracer flux methods
  publication-title: J Cyst Fibros : Off J Eur Cyst Fibros Soc
  doi: 10.1016/j.jcf.2004.05.025
– volume: 77
  start-page: 69
  issue: 1
  year: 2010
  end-page: 78
  ident: CR60
  article-title: Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.109.061051
– volume: 24
  start-page: 4178
  issue: 11
  year: 2010
  end-page: 4186
  ident: CR41
  article-title: Inhibition of Ca -activated Cl channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea
  publication-title: FASEB J : Off Publ Federation of Am Soc Exp Biol
  doi: 10.1096/fj.10-160648
– volume: 10
  start-page: 51
  year: 2019
  ident: CR40
  article-title: Drug Repurposing: The anthelmintics niclosamide and nitazoxanide are potent TMEM16A antagonists that fully bronchodilate airways
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2019.00051
– volume: 189
  start-page: 2393
  issue: 6
  year: 2013
  ident: CR2
  article-title: Re: inhibition of Ca -activated Cl channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma
  publication-title: J Urol
  doi: 10.1016/j.juro.2013.02.107
– volume: 37
  start-page: 703
  issue: 5
  year: 2020
  ident: 188_CR3
  publication-title: Nat Prod Rep
  doi: 10.1039/c9np00056a
– volume: 168
  start-page: 773
  issue: 3
  year: 2013
  ident: 188_CR16
  publication-title: Br J Pharmacol
  doi: 10.1111/j.1476-5381.2012.02199.x
– volume: 146
  year: 2019
  ident: 188_CR24
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2019.104323
– volume: 57
  start-page: 1
  issue: 1
  year: 2014
  ident: 188_CR34
  publication-title: J Pediatr
  doi: 10.3345/kjp.2014.57.1.1
– volume: 468
  start-page: 443
  issue: 3
  year: 2016
  ident: 188_CR45
  publication-title: Pflugers Arch
  doi: 10.1007/s00424-016-1790-0
– volume: 118
  start-page: 262
  issue: 1
  year: 2020
  ident: 188_CR26
  publication-title: Biophys J
  doi: 10.1016/j.bpj.2019.11.015
– volume: 34
  start-page: 13430
  issue: 10
  year: 2020
  ident: 188_CR30
  publication-title: FASEB J
  doi: 10.1096/fj.202000443RR
– volume: 234
  start-page: 7856
  issue: 6
  year: 2019
  ident: 188_CR29
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.27865
– volume: 275
  start-page: 6047
  issue: 9
  year: 2000
  ident: 188_CR28
  publication-title: J Biol Chem
  doi: 10.1074/jbc.275.9.6047
– volume: 355
  start-page: 229
  year: 2014
  ident: 188_CR66
  publication-title: J Theor Biol
  doi: 10.1016/j.jtbi.2014.04.004
– volume: 189
  start-page: 2393
  issue: 6
  year: 2013
  ident: 188_CR2
  publication-title: J Urol
  doi: 10.1016/j.juro.2013.02.107
– volume: 10
  issue: 7
  year: 2015
  ident: 188_CR54
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0133656
– volume: 77
  start-page: 69
  issue: 1
  year: 2010
  ident: 188_CR60
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.109.061051
– volume: 172
  start-page: 2459
  issue: 10
  year: 2015
  ident: 188_CR7
  publication-title: Br J Pharmacol
  doi: 10.1111/bph.13077
– volume: 73
  start-page: 758
  issue: 3
  year: 2008
  ident: 188_CR17
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.107.043208
– volume: 160
  start-page: 245
  year: 2018
  ident: 188_CR57
  publication-title: Eur J Med Chem
  doi: 10.1016/j.ejmech.2018.10.002
– volume: 82
  start-page: 22
  year: 2015
  ident: 188_CR63
  publication-title: J Mol Cell Cardiol
  doi: 10.1016/j.yjmcc.2015.02.020
– volume: 286
  start-page: 2365
  issue: 3
  year: 2011
  ident: 188_CR42
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M110.175109
– volume: 250
  start-page: 483
  issue: 5
  year: 2017
  ident: 188_CR11
  publication-title: J Membr Biol
  doi: 10.1007/s00232-017-9975-9
– volume: 286
  start-page: 13393
  issue: 15
  year: 2011
  ident: 188_CR39
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M110.196089
– volume: 156
  year: 2020
  ident: 188_CR68
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2020.104763
– volume: 18
  start-page: 134
  issue: 3
  year: 2020
  ident: 188_CR27
  publication-title: Assay Drug Dev Technol
  doi: 10.1089/adt.2019.962
– volume: 84
  start-page: 726
  issue: 5
  year: 2013
  ident: 188_CR46
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.113.087502
– volume: 499
  start-page: 220
  issue: 3
  year: 2001
  ident: 188_CR20
  publication-title: FEBS Lett
  doi: 10.1016/s0014-5793(01)02561-3
– volume: 7
  start-page: 10
  issue: 1
  year: 2011
  ident: 188_CR1
  publication-title: Curr Comput Aided Drug Des
  doi: 10.2174/157340911793743547
– volume: 552
  start-page: 426
  issue: 7685
  year: 2017
  ident: 188_CR15
  publication-title: Nature
  doi: 10.1038/nature25024
– volume: 7
  start-page: 270
  year: 2016
  ident: 188_CR31
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2016.00270
– volume: 110
  start-page: E1026
  issue: 11
  year: 2013
  ident: 188_CR5
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1217072110
– volume: 234
  start-page: 8698
  issue: 6
  year: 2019
  ident: 188_CR23
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.27529
– volume: 322
  start-page: 590
  issue: 5901
  year: 2008
  ident: 188_CR10
  publication-title: Science (NY)
  doi: 10.1126/science.1163518
– volume: 4
  issue: 15
  year: 2019
  ident: 188_CR8
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.128414
– volume: 6
  start-page: 17
  issue: 1
  year: 2012
  ident: 188_CR13
  publication-title: Expert Rev Gastroenterol Hepatol
  doi: 10.1586/egh.11.87
– volume: 10
  issue: 12
  year: 2015
  ident: 188_CR59
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0144715
– volume: 552
  start-page: 421
  issue: 7685
  year: 2017
  ident: 188_CR47
  publication-title: Nature
  doi: 10.1038/nature24652
– volume: 11
  issue: 5
  year: 2016
  ident: 188_CR55
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0155771
– year: 2017
  ident: 188_CR9
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/s13046-017-0499-z
– volume: 1
  start-page: 15010
  year: 2015
  ident: 188_CR51
  publication-title: Cyst Fibros Nature Rev Dis Primers
  doi: 10.1038/nrdp.2015.10
– volume: 8
  start-page: 153
  issue: 2
  year: 2009
  ident: 188_CR62
  publication-title: Nat Rev Drug Discovery
  doi: 10.1038/nrd2780
– ident: 188_CR22
  doi: 10.1007/s00424-017-1934-x
– volume: 18
  start-page: 714
  year: 2020
  ident: 188_CR58
  publication-title: Comput Struct Biotechnol J
  doi: 10.1016/j.csbj.2020.03.015
– volume: 12
  issue: 3
  year: 2017
  ident: 188_CR56
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0174935
– volume: 60
  start-page: 4626
  issue: 11
  year: 2017
  ident: 188_CR61
  publication-title: J Med Chem
  doi: 10.1021/acs.jmedchem.7b00020
– volume: 406
  start-page: 1713
  issue: 6
  year: 2014
  ident: 188_CR50
  publication-title: Anal Bioanal Chem
  doi: 10.1007/s00216-013-7550-5
– volume: 155
  year: 2020
  ident: 188_CR25
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2020.104721
– volume: 7
  start-page: e43265
  issue: 8
  year: 2012
  ident: 188_CR52
  publication-title: PloSOne
  doi: 10.1371/journal.pone.0043265
– volume: 10
  start-page: 51
  year: 2019
  ident: 188_CR40
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2019.00051
– volume: 3
  start-page: 119
  issue: Suppl 2
  year: 2004
  ident: 188_CR44
  publication-title: J Cyst Fibros : Off J Eur Cyst Fibros Soc
  doi: 10.1016/j.jcf.2004.05.025
– volume: 22
  start-page: 1375
  issue: 6
  year: 2003
  ident: 188_CR33
  publication-title: Int J Oncol
– volume: 5
  start-page: 16657
  year: 2015
  ident: 188_CR19
  publication-title: Sci Rep
  doi: 10.1038/srep16657
– volume: 174
  start-page: 2334
  issue: 14
  year: 2017
  ident: 188_CR67
  publication-title: Br J Pharmacol
  doi: 10.1111/bph.13841
– volume: 134
  start-page: 1019
  issue: 6
  year: 2008
  ident: 188_CR53
  publication-title: Cell
  doi: 10.1016/j.cell.2008.09.003
– year: 2015
  ident: 188_CR18
  publication-title: Molecular Pain
  doi: 10.1186/s12990-015-0061-y
– volume: 35
  start-page: 2422
  issue: 6
  year: 2015
  ident: 188_CR21
  publication-title: Cell Physiol Biochem: Int J Exp Cell Physiol, Biochem, Pharmacol
  doi: 10.1159/000374043
– volume: 468
  start-page: 1241
  issue: 7
  year: 2016
  ident: 188_CR12
  publication-title: Pflugers Arch
  doi: 10.1007/s00424-016-1830-9
– volume: 31
  start-page: 1362
  issue: 6
  year: 2016
  ident: 188_CR49
  publication-title: J Enzyme Inhib Med Chem
  doi: 10.3109/14756366.2015.1135912
– volume: 19
  start-page: 3204
  issue: 10
  year: 2018
  ident: 188_CR36
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms19103204
– volume: 120
  start-page: 1240
  issue: 4
  year: 2010
  ident: 188_CR37
  publication-title: J Clin Investig
  doi: 10.1172/JCI41084
– volume: 25
  start-page: 4048
  issue: 11
  year: 2011
  ident: 188_CR43
  publication-title: FASEB J : Off Publ Fed Am Soc Exp Biol
  doi: 10.1096/fj.11-191627
– volume: 10
  start-page: 3
  year: 2019
  ident: 188_CR35
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2019.00003
– volume: 342
  start-page: 309
  year: 1983
  ident: 188_CR4
  publication-title: J Physiol
  doi: 10.1113/jphysiol.1983.sp014852
– volume: 24
  start-page: 4178
  issue: 11
  year: 2010
  ident: 188_CR41
  publication-title: FASEB J : Off Publ Federation of Am Soc Exp Biol
  doi: 10.1096/fj.10-160648
– volume: 201
  start-page: 946
  issue: 8
  year: 2020
  ident: 188_CR14
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201908-1641OC
– volume: 467
  start-page: 1417
  issue: 7
  year: 2015
  ident: 188_CR38
  publication-title: Pflugers Arch
  doi: 10.1007/s00424-014-1572-5
– volume: 516
  start-page: 207
  issue: 7530
  year: 2014
  ident: 188_CR6
  publication-title: Nature
  doi: 10.1038/nature13984
– volume: 455
  start-page: 1210
  issue: 7217
  year: 2008
  ident: 188_CR64
  publication-title: Nature
  doi: 10.1038/nature07313
– volume: 7
  start-page: e38030
  issue: 5
  year: 2012
  ident: 188_CR65
  publication-title: PloS One
  doi: 10.1371/journal.pone.0038030
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Snippet Calcium-activated chloride channels (CaCCs) are widespread chloride channels which rely on calcium activation to perform their functions. In 2008, TMEM16A...
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SubjectTerms Anoctamin-1 - genetics
Asthma
Biochemistry
Biomedical and Life Sciences
Calcium - metabolism
Calcium channels
Calcium chloride
Cancer
Chloride channels (calcium-gated)
Chloride Channels - genetics
Chloride ions
Excitability
Fertilization
Gastric motility
Gastrointestinal Motility
Human Physiology
Ion channels
Life Sciences
Modulators
Motility
Muscle contraction
Muscles
Muscular function
Neuromodulation
Physiology
Smooth muscle
Therapeutic targets
Topical Review
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Title Emerging Modulators of TMEM16A and Their Therapeutic Potential
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