Sulopenem: An Intravenous and Oral Penem for the Treatment of Urinary Tract Infections Due to Multidrug-Resistant Bacteria - Zhanel, George G.; Pozdirca, Marianna; Golden, Alyssa R.; Lawrence, Courtney K.; Zelenitsky, Sheryl; Berry, Liam; Schweizer, Frank; Bay, Denice; Adam, Heather; Zhanel, Michael A.; Lagacé-Wiens, Philippe; Walkty, Andrew; et al. (Drugs (New York, N.Y.), 2022)
Keywords: Absorption; Aerobes; Alkylates; Alkylation; Amides; Anaerobes; Animal models; Animals; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibiotics; Antiinfectives and antibacterials; Asymptomatic; Bacteria; Bacterial infections; Bactericidal activity; Bacteriostasis; Bacteriuria; Bacteriuria - chemically induced; Bacteriuria - drug therapy; beta-Lactamases - pharmacology; Bioavailability; Bronchopulmonary infection; Carbapenemase; Carbapenems; Carbapenems - pharmacology; Cephalosporins; Cephalosporins - pharmacology; Ciprofloxacin; Ciprofloxacin - pharmacology; Citrobacter; Clinical trials; Crosslinking; Drug resistance; E coli; Efflux; Enterobacter cloacae; Enterobacterales; Enterococcus faecalis; Ertapenem; Escherichia coli; Female; Fluoroquinolones - pharmacology; Food consumption; Gram-Negative Bacteria; Guinea Pigs; Humans; Imipenem - pharmacology; Internal Medicine; Ionization; Isomers; Kidneys; Klebsiella pneumoniae; Lactams; Listeria monocytogenes; Low molecular weights; Male; Medicine; Medicine & Public Health; Membrane proteins; Membrane Proteins - pharmacology; Membranes; Meropenem - pharmacology; Methicillin-Resistant Staphylococcus aureus; Mice; Microorganisms; Minimum inhibitory concentration; Multidrug resistance; Multidrug resistant organisms; Nausea; Pathogens; Patients; Penicillin; Pharmacokinetics; Pharmacology; Pharmacology/Toxicology; Pharmacotherapy; Phenotypes; Probenecid - pharmacology; Prodrugs - pharmacology; Proteins; Public health; Regulatory approval; Review Article; Safety; Staphylococcus aureus; Staphylococcus epidermidis; Staphylococcus infections; Streptococcus agalactiae; Streptococcus infections; Streptococcus pneumoniae; Streptococcus pyogenes; Therapy; Urinary tract diseases; Urinary tract infections; Urinary Tract Infections - drug therapy; Urine; Urogenital system; Vomiting; β-Lactam antibiotics