The negative effect of magnetic nanoparticles with ascorbic acid on peritoneal macrophages

• Published in: Neurochemical research Vol. 45; no. 1; pp. 159 - 170
• Main Authors: Jiráková, Klára, Moskvin, Maksym, Machová Urdzíková, Lucia, Rössner, Pavel, Elzeinová, Fatima, Chudíčková, Milada, Jirák, Daniel, Ziolkowska, Natalia, Horák, Daniel, Kubinová, Šárka, Jendelová, Pavla
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2020; Springer Nature B.V
• Subjects: Acids; Ascorbic acid; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biomolecules; Cell Biology; Cell viability; Coating effects; Contrast agents; Cultivation; Cytotoxicity; Deoxyribonucleic acid; DNA; Exposure; Gene expression; Iron oxides; Lipid peroxidation; Lipids; Macrophages; Nanoparticles; Neurochemistry; Neurology; Neurosciences; Original Paper; Oxidative stress; Peritoneum; Peroxidation; Silica; Silicon dioxide; Toxicity; Transmission electron microscopy; Vitamin C; Nanoparticles; Oxidative stress; Cytotoxicity; Macrophages

Superparamagnetic iron oxide nanoparticles (SPIOn) are widely used as a contrast agent for cell labeling. Macrophages are the first line of defense of organisms in contact with nanoparticles after their administration. In this study we investigated the effect of silica-coated nanoparticles (γ-Fe 2 O...