Enhancing the Therapeutic Potential of Mesenchymal Stem Cells with the CRISPR-Cas System

• Published in: Stem cell reviews Vol. 15; no. 4; pp. 463 - 473
• Main Authors: Filho, Daniel Mendes, de Carvalho Ribeiro, Patrícia, Oliveira, Lucas Felipe, dos Santos, Ana Luiza Romero Terra, Parreira, Ricardo Cambraia, Pinto, Mauro Cunha Xavier, Resende, Rodrigo Ribeiro
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2019; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Cell Biology; Clinical trials; CRISPR; Genetic engineering; Genomes; Immunomodulation; Life Sciences; Mesenchymal stem cells; Mesenchyme; Regenerative Medicine/Tissue Engineering; Security management; Stem Cells; Teratogenicity; Trophic factors; CRISPR-Cas; Mesenchymal stromal cells; Genetic engineering; Cell therapy; Mesenchymal stem cells

Mesenchymal stem cells (MSCs), also known as multipotent mesenchymal stromal stem cells, are found in the perivascular space of several tissues. These cells have been subject of intense research in the last decade due to their low teratogenicity, as well as their ability to differentiate into mature...