Differentiation of Neurons, Astrocytes, Oligodendrocytes and Microglia From Human Induced Pluripotent Stem Cells to Form Neural Tissue-On-Chip: A Neuroinflammation Model to Evaluate the Therapeutic Potential of Extracellular Vesicles Derived from Mesenchymal Stem Cells

Advances in stem cell (SC) technology allow the generation of cellular models that recapitulate the histological, molecular and physiological properties of humanized in vitro three dimensional (3D) models, as well as production of cell-derived therapeutics such as extracellular vesicles (EVs). Impro...

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Published inStem cell reviews and reports Vol. 20; no. 1; pp. 413 - 436
Main Authors Saglam-Metiner, Pelin, Duran, Elif, Sabour-Takanlou, Leila, Biray-Avci, Cigir, Yesil-Celiktas, Ozlem
Format Journal Article
LanguageEnglish
Published New York Springer US 2024
Springer Nature B.V
Subjects
Astrocytes
Biochips
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
CD9 antigen
Cell Biology
Cell differentiation
Extracellular Vesicles
Glial cells
Humans
Induced Pluripotent Stem Cells
Inflammation
Life Sciences
Mesenchymal Stem Cells
Microglia
Neural stem cells
Neuroinflammatory Diseases
Neuronal-glial interactions
Neurons
Oligodendrocytes
Oligodendroglia
Pluripotency
Regenerative Medicine/Tissue Engineering
Stem Cells
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Extracellular vesicles
Neuroinflammation
Organ-on-a-chip
Differentiation
Induced pluripotent stem cells
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Abstract Advances in stem cell (SC) technology allow the generation of cellular models that recapitulate the histological, molecular and physiological properties of humanized in vitro three dimensional (3D) models, as well as production of cell-derived therapeutics such as extracellular vesicles (EVs). Improvements in organ-on-chip platforms and human induced pluripotent stem cells (hiPSCs) derived neural/glial cells provide unprecedented systems for studying 3D personalized neural tissue modeling with easy setup and fast output. Here, we highlight the key points in differentiation procedures for neurons, astrocytes, oligodendrocytes and microglia from single origin hiPSCs. Additionally, we present a well-defined humanized neural tissue-on-chip model composed of differentiated cells with the same genetic backgrounds, as well as the therapeutic potential of bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles to propose a novel treatment for neuroinflammation derived diseases. Around 100 nm CD9  + EVs promote a more anti-inflammatory and pro-remodeling of cell–cell interaction cytokine responses on tumor necrosis factor-α (TNF-α) induced neuroinflammation in neural tissue-on-chip model which is ideal for modeling authentic neural-glial patho-physiology. Graphical Abstract
AbstractList Advances in stem cell (SC) technology allow the generation of cellular models that recapitulate the histological, molecular and physiological properties of humanized in vitro three dimensional (3D) models, as well as production of cell-derived therapeutics such as extracellular vesicles (EVs). Improvements in organ-on-chip platforms and human induced pluripotent stem cells (hiPSCs) derived neural/glial cells provide unprecedented systems for studying 3D personalized neural tissue modeling with easy setup and fast output. Here, we highlight the key points in differentiation procedures for neurons, astrocytes, oligodendrocytes and microglia from single origin hiPSCs. Additionally, we present a well-defined humanized neural tissue-on-chip model composed of differentiated cells with the same genetic backgrounds, as well as the therapeutic potential of bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles to propose a novel treatment for neuroinflammation derived diseases. Around 100 nm CD9 + EVs promote a more anti-inflammatory and pro-remodeling of cell-cell interaction cytokine responses on tumor necrosis factor-α (TNF-α) induced neuroinflammation in neural tissue-on-chip model which is ideal for modeling authentic neural-glial patho-physiology.
Advances in stem cell (SC) technology allow the generation of cellular models that recapitulate the histological, molecular and physiological properties of humanized in vitro three dimensional (3D) models, as well as production of cell-derived therapeutics such as extracellular vesicles (EVs). Improvements in organ-on-chip platforms and human induced pluripotent stem cells (hiPSCs) derived neural/glial cells provide unprecedented systems for studying 3D personalized neural tissue modeling with easy setup and fast output. Here, we highlight the key points in differentiation procedures for neurons, astrocytes, oligodendrocytes and microglia from single origin hiPSCs. Additionally, we present a well-defined humanized neural tissue-on-chip model composed of differentiated cells with the same genetic backgrounds, as well as the therapeutic potential of bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles to propose a novel treatment for neuroinflammation derived diseases. Around 100 nm CD9 + EVs promote a more anti-inflammatory and pro-remodeling of cell-cell interaction cytokine responses on tumor necrosis factor-α (TNF-α) induced neuroinflammation in neural tissue-on-chip model which is ideal for modeling authentic neural-glial patho-physiology.
Advances in stem cell (SC) technology allow the generation of cellular models that recapitulate the histological, molecular and physiological properties of humanized in vitro three dimensional (3D) models, as well as production of cell-derived therapeutics such as extracellular vesicles (EVs). Improvements in organ-on-chip platforms and human induced pluripotent stem cells (hiPSCs) derived neural/glial cells provide unprecedented systems for studying 3D personalized neural tissue modeling with easy setup and fast output. Here, we highlight the key points in differentiation procedures for neurons, astrocytes, oligodendrocytes and microglia from single origin hiPSCs. Additionally, we present a well-defined humanized neural tissue-on-chip model composed of differentiated cells with the same genetic backgrounds, as well as the therapeutic potential of bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles to propose a novel treatment for neuroinflammation derived diseases. Around 100 nm CD9  + EVs promote a more anti-inflammatory and pro-remodeling of cell–cell interaction cytokine responses on tumor necrosis factor-α (TNF-α) induced neuroinflammation in neural tissue-on-chip model which is ideal for modeling authentic neural-glial patho-physiology. Graphical Abstract
Author Saglam-Metiner, Pelin
Sabour-Takanlou, Leila
Biray-Avci, Cigir
Duran, Elif
Yesil-Celiktas, Ozlem
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Keywords Extracellular vesicles
Neuroinflammation
Organ-on-a-chip
Differentiation
Induced pluripotent stem cells
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SSID ssj0002304015
Score 2.312019
Snippet Advances in stem cell (SC) technology allow the generation of cellular models that recapitulate the histological, molecular and physiological properties of...
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SubjectTerms Astrocytes
Biochips
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
CD9 antigen
Cell Biology
Cell differentiation
Extracellular Vesicles
Glial cells
Humans
Induced Pluripotent Stem Cells
Inflammation
Life Sciences
Mesenchymal Stem Cells
Microglia
Neural stem cells
Neuroinflammatory Diseases
Neuronal-glial interactions
Neurons
Oligodendrocytes
Oligodendroglia
Pluripotency
Regenerative Medicine/Tissue Engineering
Stem Cells
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Title Differentiation of Neurons, Astrocytes, Oligodendrocytes and Microglia From Human Induced Pluripotent Stem Cells to Form Neural Tissue-On-Chip: A Neuroinflammation Model to Evaluate the Therapeutic Potential of Extracellular Vesicles Derived from Mesenchymal Stem Cells
URI https://link.springer.com/article/10.1007/s12015-023-10645-8
https://www.ncbi.nlm.nih.gov/pubmed/37938408
https://www.proquest.com/docview/2916737133
https://search.proquest.com/docview/2887474760
Volume 20
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