Localization of VEGF, TGF-β1, BMP-2, and Apoptosis Factors in Hypertrophic Nonunion of Human Tubular Bones

• Published in: Bulletin of experimental biology and medicine Vol. 173; no. 1; pp. 160 - 168
• Main Authors: Kostiv, R. E., Matveeva, N. Yu, Kalinichenko, S. G.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2022; Springer Nature B.V
• Subjects: Apoptosis; Autopsy; Bcl-2 protein; Biomedical and Life Sciences; Biomedicine; Bone morphogenetic protein 2; Callus; Caspase-3; Cell Biology; Chondroblasts; Clavicle; Connective tissues; Cytotoxicity; Femur; Fibroblasts; Fractures; Internal Medicine; Laboratory Medicine; Localization; Microvasculature; Musculoskeletal system; Nonunion; Osteoblasts; Osteons; Pathology; Periosteum; Tibia; Transforming growth factor-b1; Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine); Tumor necrosis factor-α; Ulna; Vascular endothelial growth factor; fracture nonunion; stromal stem cells; osteoblasts, proliferation; bone tissue remodeling

We studied localization of VEGF, TGF-β1, BMP-2, caspase-3, Bcl-2, and TNFα in the callus samples obtained from 5 patients (4 women and 1 man) aged 41-53 years during planned surgery for nonunion and pseudarthrosis of the clavicle ( n =1), ulna ( n =1), femur ( n =1), and tibia ( n =2) bones. Two con...