Genetic and genomic signatures in ethanol withdrawal seizure-prone and seizure-resistant mice implicate genes involved in epilepsy and neuronal excitability

• Published in: Molecular psychiatry Vol. 27; no. 11; pp. 4611 - 4623
• Main Authors: Zhou, Zhifeng, Metten, Pamela, Yuan, Qiaoping, Sun, Hui, Hodgkinson, Colin A., Shen, Pei-Hong, Marietta, Cheryl, Crabbe, John C., Goldman, David
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2022; Nature Publishing Group
• Subjects: 38/39; 38/91; 45; 45/23; 45/43; 631/208; 631/378; 64/60; Alcohol withdrawal; Alcoholism - genetics; Animal models; Animals; Association analysis; Behavioral Sciences; Biological Psychology; Convulsions; Convulsions & seizures; Epilepsy; Ethanol; Excitability; Genetic analysis; Genomics; Glutamatergic transmission; Humans; Medicine; Medicine & Public Health; Mice; Neurosciences; Pharmacotherapy; Phenotypes; Polygenic inheritance; Prefrontal cortex; Psychiatry; Quantitative trait loci; Seizures; Seizures - genetics; Substance Withdrawal Syndrome - genetics; Synaptic transmission; Transcriptomes; Transcriptomics; γ-Aminobutyric acid

Alcohol withdrawal is a clinically important consequence and potential driver of Alcohol Use Disorder. However, susceptibility to withdrawal symptoms, ranging from craving and anxiety to seizures and delirium, varies greatly. Selectively bred Withdrawal Seizure-Prone (WSP) and Seizure-Resistant (WSR...