Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer

• Published in: Cancer immunology research Vol. 7; no. 10; p. 1605
• Main Authors: Wu, Wen-Chao, Sun, Hong-Wei, Chen, Jing, OuYang, Han-Yue, Yu, Xing-Juan, Chen, Hai-Tian, Shuang, Ze-Yu, Shi, Ming, Wang, Zilian, Zheng, Limin
• Format: Journal Article
• Language: English
• Published: United States 01.10.2019

Tumor-associated myeloid cells are one of the prominent components of solid tumors, serving as major immune regulators for the tumor microenvironment (TME) and an obstacle for immune-checkpoint blocking (ICB) therapy. However, it remains unclear how metabolic processes regulate the generation of sup...