TNFSF13 upregulation confers chemotherapeutic resistance via triggering autophagy initiation in triple-negative breast cancer

• Published in: Journal of molecular medicine (Berlin, Germany) Vol. 98; no. 9; pp. 1255 - 1267
• Main Authors: Lin, Hui-Yu, Kuei, Chia-Hao, Lee, Hsun-Hua, Lin, Che-Hsuan, Chen, Yen-Lin, Chen, Chi-Long, Lin, Yuan-Feng
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2020; Springer Nature B.V
• Subjects: AKT protein; Anthracycline; Autophagy; Biomarkers; Biomedical and Life Sciences; Biomedicine; Breast cancer; Cancer therapies; Chemoresistance; Chemotherapy; Doxorubicin; Estrogen receptors; Gene expression; Human Genetics; Immunohistochemistry; Internal Medicine; Molecular Medicine; Original Article; Paclitaxel; Phagocytosis; Therapeutic targets; TOR protein; Up-regulation; Western blotting; Chemotherapy; Autophagy; Paclitaxel; Triple-negative breast cancer; TNFSF13

Since chemotherapy is a main strategy to treat triple-negative breast cancer (TNBC) patients currently, identifying a biomarker to predict chemotherapeutic responses is urgently needed for patients to avoid suffering through unnecessary chemotherapeutic treatments. Here, we found that the endogenous...