Mitochondrial dysfunction is a major cause of thromboinflammation and inflammatory cell death in critical illnesses

• Published in: Inflammation research Vol. 74; no. 1; p. 17
• Main Authors: Iba, Toshiaki, Helms, Julie, Maier, Cheryl L., Ferrer, Ricard, Levy, Jerrold H.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2025; Springer Nature B.V
• Subjects: Adenosine triphosphate; Allergology; Animals; Apoptosis; ATP; Biomedical and Life Sciences; Biomedicine; Cell Death; Coagulation; Critical Illness; Cytochrome c; Damage; Dermatology; DNA damage; External stimuli; Ferroptosis; Heat stroke; Humans; Hypoxia; Illnesses; Immunology; Inflammation; Inflammation - pathology; Leukocytes (granulocytic); Mitochondria; Mitochondria - pathology; Mitochondria - physiology; Mitochondrial DNA; Monocytes; Mortality; Necroptosis; Necrosis; Neurology; Oxygen; Pharmacology/Toxicology; Pyroptosis; Reactive oxygen species; Reactive Oxygen Species - metabolism; Review; Rheumatology; Sepsis; Thromboinflammation - pathology; Trauma; Neutrophil extracellular trap; Ferroptosis; Mitochondria; Pyroptosis; Apoptosis

Background Mitochondria generate the adenosine triphosphate (ATP) necessary for eukaryotic cells, serving as their primary energy suppliers, and contribute to host defense by producing reactive oxygen species. In many critical illnesses, including sepsis, major trauma, and heatstroke, the vicious cy...