PEG2000-PLA-based nanoscale polymeric micelles reduce paclitaxel-related toxicity in beagle dogs - Lu, Jun; Han, Bo; Zhang, Bo; Zou, Benkun; Hu, Minjuan; Liu, Hongyu; Zhou, Chao; Qian, Fangfei; Wang, Shuyuan; Zhang, Yanwei; Lou, Yuqing; Chu, Tianqing; et al. (Journal of controlled release, 2023)
Keywords: acute toxicity; Beagle; Beagles model; digestive system; drugs; heart; lethal dose; lung neoplasms; micelles; Nanocarrier; nanocarriers; Paclitaxel; peripheral nervous system diseases; Polymeric micellar; polymers; Toxicity; toxicity testing; LYMPH; MCV; PT; ALP; Sb-Pac; ALT; hr; AUC; GLU; RBC; MPV; PFS; Pm; HGB; Ctrl; NEUT; Nanocarrier; MCHC; T.P; HCT; Polymeric micellar; FDA; Toxicity; BASO; T.CHO; MONO; ORR; PDI; CREA; ANOVA; Paclitaxel; WBC; PLT; BUN; Pm-Pac; HPLC; Cmax; AST; NSCLC; RDW; EOS; CK; γ-GT; ECG; CL; MCH; TG; ALB; Beagles model; PK; TEM; HE; T.BIL; RETIC