The role of 7 T MRI to assess atrophy of the subcortical deep gray matter in relapsing–remitting multiple sclerosis

• Published in: Journal of neurology Vol. 271; no. 10; pp. 6935 - 6943
• Main Authors: Callen, Alexis M., Zurawski, Jonathan, Chu, Renxin, Tie, Yanmei, Tauhid, Shahamat, Quattrucci, Molly, Healy, Brian C., Bakshi, Rohit
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2024; Springer Nature B.V
• Subjects: Adult; Atrophy; Atrophy - pathology; Automation; Brain - diagnostic imaging; Brain - pathology; Disability Evaluation; Female; Globus pallidus; Gray Matter - diagnostic imaging; Gray Matter - pathology; Humans; Image processing; Image Processing, Computer-Assisted; Lesions; Magnetic Resonance Imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Multiple sclerosis; Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging; Multiple Sclerosis, Relapsing-Remitting - pathology; Neurology; Neuroradiology; Neurosciences; Original Communication; Putamen; Substantia alba; Substantia grisea; Thalamus; Atrophy; Disability; Thalamus; Multiple sclerosis; 7 T; MRI

Background Deep gray matter (DGM) atrophy and lesions are found in multiple sclerosis (MS). Objective To optimize automated segmentation for 7 T DGM volumetrics and assess sensitivity to atrophy and relationship to DGM lesions and disability in relapsing–remitting (RR) MS. Methods 30 RRMS subjects [...