No differences in rest myocardial blood flow in stunned and hibernating myocardium: insights into the pathophysiology of ischemic cardiomyopathy

• Published in: European journal of nuclear medicine and molecular imaging Vol. 46; no. 11; pp. 2322 - 2328
• Main Authors: Benz, Dominik C., von Dahlen, Anita P., Huang, Wenjie, Messerli, Michael, von Felten, Elia, Benetos, Georgios, Giannopoulos, Andreas A., Fuchs, Tobias A., Gräni, Christoph, Gebhard, Catherine, Pazhenkottil, Aju P., Gaemperli, Oliver, Kaufmann, Philipp A., Buechel, Ronny R.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2019; Springer Nature B.V
• Subjects: Aged; Ammonia; Blood flow; Cardiology; Cardiomyopathies; Cardiomyopathy; Echocardiography; Emission analysis; Female; Fluorodeoxyglucose F18; Heart; Heart - diagnostic imaging; Heart - physiopathology; Hibernation; Humans; Imaging; Ischemia; Male; Medicine; Medicine & Public Health; Middle Aged; Motion; Myocardial Ischemia - diagnostic imaging; Myocardial Ischemia - physiopathology; Myocardial Perfusion Imaging; Myocardium; Myocardium - pathology; Myocytes; Nuclear Medicine; Oncology; Original Article; Orthopedics; Perfusion; Positron emission; Positron emission tomography; Predictive Value of Tests; Radiology; Rest; Retrospective Studies; Ventricular Dysfunction, Left; Viability; Myocardial blood flow; Stunning; Hibernating myocardium; Myocardial flow reserve; Viability testing

Purpose The human pathophysiology of stunned, hibernating and scarred myocardium in ischemic cardiomyopathy is a subject of controversy. While the “smart heart” theory postulates that reduced myocardial blood flow (MBF) at rest is responsible for myocytes switching to a state of hibernation, other t...