Insulin resistance and cardiometabolic indexes: comparison of concordance in working-age subjects with overweight and obesity

Purpose The aim of the study was to evaluate indexes of insulin resistance and cardiometabolic risk in a large population of workers with overweight or obesity, in order to identify a possible efficient, cheap and simple strategy to apply in workers’ health surveillance. Methods The evaluation of IR...

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Published in	Endocrine Vol. 77; no. 2; pp. 231 - 241
Main Authors	Vigna, Luisella, Tirelli, Amedea Silvia, Gaggini, Melania, Di Piazza, Salvina, Tomaino, Laura, Turolo, Stefano, Moroncini, Gianluca, Chatzianagnostou, Kyriazoula, Bamonti, Fabrizia, Vassalle, Cristina
Format	Journal Article
Language	English
Published	New York Springer US 01.08.2022 Springer Nature B.V
Subjects	Aging Blood pressure Body weight Diabetes Endocrinology Fibrinogen Homocysteine Humanities and Social Sciences Insulin Insulin resistance Internal Medicine Medicine Medicine & Public Health multidisciplinary Obesity Original Article Overweight Science Uric acid Workers Cardiometabolic indexes Cardiometabolic risk Insulin resistance indexes Working-age subjects Occupational medicine
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Abstract	Purpose The aim of the study was to evaluate indexes of insulin resistance and cardiometabolic risk in a large population of workers with overweight or obesity, in order to identify a possible efficient, cheap and simple strategy to apply in workers’ health surveillance. Methods The evaluation of IR and cardiometabolic risk indexes (HOMA, QUICKI, Ty/HDLC, TyG, insuTAG, Castelli risk indexes 1 and 2, non-HDLC, TRL-C, AIP, and VAI) was performed in a population of 1195 working-age subjects with overweight or obesity (322 males, mean age 49 ± 11 years). Results The prevalence of IR and cardiometabolic risk was higher among males for all indexes. Aging, waist circumference, BMI, blood pressure, glucose, CRP, fibrinogen and uric acid were correlated more frequently with IR/cardiometabolic indexes in women, homocysteine in men. The percentage of the workers identified as insulin resistant (IR+) or at higher cardiometabolic risk greatly vary according to the different index used. Conclusion With a small group of biomarkers and anthropometric measures (fasting glucose and insulin, lipid profile, BMI and waist circumference) is possible to calculate a number of IR/cardiometabolic indexes, which, likely reflecting different pathophysiological aspects also related to gender, might help in a personalized evaluation of IR and cardiometabolic risk. Graphical abstract
AbstractList	The aim of the study was to evaluate indexes of insulin resistance and cardiometabolic risk in a large population of workers with overweight or obesity, in order to identify a possible efficient, cheap and simple strategy to apply in workers' health surveillance. The evaluation of IR and cardiometabolic risk indexes (HOMA, QUICKI, Ty/HDLC, TyG, insuTAG, Castelli risk indexes 1 and 2, non-HDLC, TRL-C, AIP, and VAI) was performed in a population of 1195 working-age subjects with overweight or obesity (322 males, mean age 49 ± 11 years). The prevalence of IR and cardiometabolic risk was higher among males for all indexes. Aging, waist circumference, BMI, blood pressure, glucose, CRP, fibrinogen and uric acid were correlated more frequently with IR/cardiometabolic indexes in women, homocysteine in men. The percentage of the workers identified as insulin resistant (IR+) or at higher cardiometabolic risk greatly vary according to the different index used. With a small group of biomarkers and anthropometric measures (fasting glucose and insulin, lipid profile, BMI and waist circumference) is possible to calculate a number of IR/cardiometabolic indexes, which, likely reflecting different pathophysiological aspects also related to gender, might help in a personalized evaluation of IR and cardiometabolic risk. Graphical abstract. Purpose The aim of the study was to evaluate indexes of insulin resistance and cardiometabolic risk in a large population of workers with overweight or obesity, in order to identify a possible efficient, cheap and simple strategy to apply in workers’ health surveillance. Methods The evaluation of IR and cardiometabolic risk indexes (HOMA, QUICKI, Ty/HDLC, TyG, insuTAG, Castelli risk indexes 1 and 2, non-HDLC, TRL-C, AIP, and VAI) was performed in a population of 1195 working-age subjects with overweight or obesity (322 males, mean age 49 ± 11 years). Results The prevalence of IR and cardiometabolic risk was higher among males for all indexes. Aging, waist circumference, BMI, blood pressure, glucose, CRP, fibrinogen and uric acid were correlated more frequently with IR/cardiometabolic indexes in women, homocysteine in men. The percentage of the workers identified as insulin resistant (IR+) or at higher cardiometabolic risk greatly vary according to the different index used. Conclusion With a small group of biomarkers and anthropometric measures (fasting glucose and insulin, lipid profile, BMI and waist circumference) is possible to calculate a number of IR/cardiometabolic indexes, which, likely reflecting different pathophysiological aspects also related to gender, might help in a personalized evaluation of IR and cardiometabolic risk. Graphical abstract The aim of the study was to evaluate indexes of insulin resistance and cardiometabolic risk in a large population of workers with overweight or obesity, in order to identify a possible efficient, cheap and simple strategy to apply in workers' health surveillance.PURPOSEThe aim of the study was to evaluate indexes of insulin resistance and cardiometabolic risk in a large population of workers with overweight or obesity, in order to identify a possible efficient, cheap and simple strategy to apply in workers' health surveillance.The evaluation of IR and cardiometabolic risk indexes (HOMA, QUICKI, Ty/HDLC, TyG, insuTAG, Castelli risk indexes 1 and 2, non-HDLC, TRL-C, AIP, and VAI) was performed in a population of 1195 working-age subjects with overweight or obesity (322 males, mean age 49 ± 11 years).METHODSThe evaluation of IR and cardiometabolic risk indexes (HOMA, QUICKI, Ty/HDLC, TyG, insuTAG, Castelli risk indexes 1 and 2, non-HDLC, TRL-C, AIP, and VAI) was performed in a population of 1195 working-age subjects with overweight or obesity (322 males, mean age 49 ± 11 years).The prevalence of IR and cardiometabolic risk was higher among males for all indexes. Aging, waist circumference, BMI, blood pressure, glucose, CRP, fibrinogen and uric acid were correlated more frequently with IR/cardiometabolic indexes in women, homocysteine in men. The percentage of the workers identified as insulin resistant (IR+) or at higher cardiometabolic risk greatly vary according to the different index used.RESULTSThe prevalence of IR and cardiometabolic risk was higher among males for all indexes. Aging, waist circumference, BMI, blood pressure, glucose, CRP, fibrinogen and uric acid were correlated more frequently with IR/cardiometabolic indexes in women, homocysteine in men. The percentage of the workers identified as insulin resistant (IR+) or at higher cardiometabolic risk greatly vary according to the different index used.With a small group of biomarkers and anthropometric measures (fasting glucose and insulin, lipid profile, BMI and waist circumference) is possible to calculate a number of IR/cardiometabolic indexes, which, likely reflecting different pathophysiological aspects also related to gender, might help in a personalized evaluation of IR and cardiometabolic risk. Graphical abstract.CONCLUSIONWith a small group of biomarkers and anthropometric measures (fasting glucose and insulin, lipid profile, BMI and waist circumference) is possible to calculate a number of IR/cardiometabolic indexes, which, likely reflecting different pathophysiological aspects also related to gender, might help in a personalized evaluation of IR and cardiometabolic risk. Graphical abstract. PurposeThe aim of the study was to evaluate indexes of insulin resistance and cardiometabolic risk in a large population of workers with overweight or obesity, in order to identify a possible efficient, cheap and simple strategy to apply in workers’ health surveillance.MethodsThe evaluation of IR and cardiometabolic risk indexes (HOMA, QUICKI, Ty/HDLC, TyG, insuTAG, Castelli risk indexes 1 and 2, non-HDLC, TRL-C, AIP, and VAI) was performed in a population of 1195 working-age subjects with overweight or obesity (322 males, mean age 49 ± 11 years).ResultsThe prevalence of IR and cardiometabolic risk was higher among males for all indexes. Aging, waist circumference, BMI, blood pressure, glucose, CRP, fibrinogen and uric acid were correlated more frequently with IR/cardiometabolic indexes in women, homocysteine in men. The percentage of the workers identified as insulin resistant (IR+) or at higher cardiometabolic risk greatly vary according to the different index used.ConclusionWith a small group of biomarkers and anthropometric measures (fasting glucose and insulin, lipid profile, BMI and waist circumference) is possible to calculate a number of IR/cardiometabolic indexes, which, likely reflecting different pathophysiological aspects also related to gender, might help in a personalized evaluation of IR and cardiometabolic risk.
Author	Di Piazza, Salvina Tomaino, Laura Tirelli, Amedea Silvia Gaggini, Melania Turolo, Stefano Bamonti, Fabrizia Vigna, Luisella Vassalle, Cristina Moroncini, Gianluca Chatzianagnostou, Kyriazoula
Author_xml	– sequence: 1 givenname: Luisella surname: Vigna fullname: Vigna, Luisella organization: Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico. Occupational Health Unit, Obesity and Work Center, EASO Collaborating Center for Obesity Management – sequence: 2 givenname: Amedea Silvia surname: Tirelli fullname: Tirelli, Amedea Silvia organization: Fondazione IRCCS Cà Grande Ospedale Maggiore Policlinico. Clinical Chemistry and Microbiology Bacteriology and Virology Units – sequence: 3 givenname: Melania surname: Gaggini fullname: Gaggini, Melania organization: Cardiometabolic Risk Unit, Institute of Clinical Physiology, CNR – sequence: 4 givenname: Salvina surname: Di Piazza fullname: Di Piazza, Salvina organization: Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico. Occupational Health Unit, Obesity and Work Center, EASO Collaborating Center for Obesity Management – sequence: 5 givenname: Laura surname: Tomaino fullname: Tomaino, Laura organization: Emergency Medicine Residency Program, Marche Polytechnic University – sequence: 6 givenname: Stefano surname: Turolo fullname: Turolo, Stefano organization: Fondazione IRCCS Cà Grande Ospedale Maggiore Policlinico. UOC Pediatric Nephrology, Dialysis and Transplantation – sequence: 7 givenname: Gianluca surname: Moroncini fullname: Moroncini, Gianluca organization: Clinica Medica, Azienda Ospedali Riuniti, Department of Internal Medicine, Azienda ospedaliera Universitaria Ospedali Riuniti – sequence: 8 givenname: Kyriazoula surname: Chatzianagnostou fullname: Chatzianagnostou, Kyriazoula organization: Fondazione G. Monasterio CNR-Regione Toscana – sequence: 9 givenname: Fabrizia surname: Bamonti fullname: Bamonti, Fabrizia organization: Former Associate Professor of Clinical Biochemistry, Board Certify in Clinical Chemistry and Biochemistry, Università degli Studi di Milano – sequence: 10 givenname: Cristina orcidid: 0000-0003-3438-6450 surname: Vassalle fullname: Vassalle, Cristina email: cristina.vassalle@ftgm.it organization: Fondazione G. Monasterio CNR-Regione Toscana
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Snippet	Purpose The aim of the study was to evaluate indexes of insulin resistance and cardiometabolic risk in a large population of workers with overweight or... The aim of the study was to evaluate indexes of insulin resistance and cardiometabolic risk in a large population of workers with overweight or obesity, in... PurposeThe aim of the study was to evaluate indexes of insulin resistance and cardiometabolic risk in a large population of workers with overweight or obesity,...
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SubjectTerms	Aging Blood pressure Body weight Diabetes Endocrinology Fibrinogen Homocysteine Humanities and Social Sciences Insulin Insulin resistance Internal Medicine Medicine Medicine & Public Health multidisciplinary Obesity Original Article Overweight Science Uric acid Workers
Title	Insulin resistance and cardiometabolic indexes: comparison of concordance in working-age subjects with overweight and obesity
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