Genetic polymorphisms of Ca2+ transport proteins and molecular chaperones in mitochondria-associated endoplasmic reticulum membrane and non-alcoholic fatty liver disease

• Published in: Frontiers in endocrinology (Lausanne) Vol. 13; p. 1056283
• Main Authors: Tang, Zongzhe, Ding, Yajie, Zhang, Ru, Zhang, Mengting, Guan, Qing, Zhang, Liuxin, Wang, Hongliang, Chen, Yue, Jiang, Rong, Zhang, Wei, Wang, Jie
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 04.01.2023
• Subjects: calcium homeostasis; Endocrinology; genetic polymorphism; heat shock 70-kDa protein 5 (HSPA5); inositol 1,4,5-trisphosphate receptor type 2 (ITPR2); non-alcoholic fatty liver disease (NAFLD)

Non-alcoholic fatty liver disease (NAFLD) is recognized to be closely associated with endoplasmic reticulum stress and mitochondrial dysfunction, while previous studies have emphasized the important role of calcium homeostasis from the mitochondria-associated endoplasmic reticulum membrane (MAM) in...