Polarization of Reactive Astrocytes in Response to Spinal Cord Injury is Enhanced by M2 Macrophage–Mediated Activation of Wnt/β-Catenin Pathway

• Published in: Molecular neurobiology Vol. 57; no. 4; pp. 1847 - 1862
• Main Authors: Sonn, Iki, Nakamura, Masaya, Renault-Mihara, Francois, Okano, Hideyuki
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2020; Springer Nature B.V
• Subjects: Animals; Astrocytes; Astrocytes - metabolism; Astrocytes - pathology; Biomedical and Life Sciences; Biomedicine; Brain injury; Cell activation; Cell Biology; Cell Polarity; Chemotaxis; Integrin beta1 - metabolism; Interleukin 4; Macrophage Activation; Macrophages; Mice, Inbred C57BL; Neurobiology; Neurology; Neurosciences; Polarization; Spinal cord injuries; Spinal Cord Injuries - metabolism; Spinal Cord Injuries - pathology; Wnt protein; Wnt Signaling Pathway; Wnt3A Protein - metabolism; β-Catenin; Polarization; Reactive astrocytes; β-Catenin pathway; Glial scar; Macrophages; Spinal cord injury; Wnt

Understanding the mechanisms of glial scar formation by reactive astrocytes is crucial for elaborating a therapeutic strategy to brain and spinal cord injury. However, the extrinsic mechanisms that drive the polarization of reactive astrocytes, the first step in glial scar formation, remain poorly u...