Polarization of Reactive Astrocytes in Response to Spinal Cord Injury is Enhanced by M2 Macrophage–Mediated Activation of Wnt/β-Catenin Pathway
Understanding the mechanisms of glial scar formation by reactive astrocytes is crucial for elaborating a therapeutic strategy to brain and spinal cord injury. However, the extrinsic mechanisms that drive the polarization of reactive astrocytes, the first step in glial scar formation, remain poorly u...
Saved in:
| Published in | Molecular neurobiology Vol. 57; no. 4; pp. 1847 - 1862 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Springer US
01.04.2020
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Understanding the mechanisms of glial scar formation by reactive astrocytes is crucial for elaborating a therapeutic strategy to brain and spinal cord injury. However, the extrinsic mechanisms that drive the polarization of reactive astrocytes, the first step in glial scar formation, remain poorly understood. Here, using an in vitro chemotaxis assay as an experimental model for polarization, we observed that Il4-M2 macrophages are stronger inducers of reactive astrocytes’ polarization, compared to naive or M1 macrophages. Then, we showed that both β1-integrin and Wnt/β-catenin pathways in astrocytes are required for this polarization in vitro and in vivo after spinal cord crush injury in mice. These findings provide molecular targets for manipulating the polarization of reactive astrocytes in order to potentially enhance the healing of SCI lesions. |
|---|---|
| AbstractList | Understanding the mechanisms of glial scar formation by reactive astrocytes is crucial for elaborating a therapeutic strategy to brain and spinal cord injury. However, the extrinsic mechanisms that drive the polarization of reactive astrocytes, the first step in glial scar formation, remain poorly understood. Here, using an in vitro chemotaxis assay as an experimental model for polarization, we observed that Il4-M2 macrophages are stronger inducers of reactive astrocytes' polarization, compared to naive or M1 macrophages. Then, we showed that both β1-integrin and Wnt/β-catenin pathways in astrocytes are required for this polarization in vitro and in vivo after spinal cord crush injury in mice. These findings provide molecular targets for manipulating the polarization of reactive astrocytes in order to potentially enhance the healing of SCI lesions. |
| Author | Nakamura, Masaya Renault-Mihara, Francois Sonn, Iki Okano, Hideyuki |
| Author_xml | – sequence: 1 givenname: Iki surname: Sonn fullname: Sonn, Iki organization: Department of Physiology, Keio University Graduate School of Medicine – sequence: 2 givenname: Masaya surname: Nakamura fullname: Nakamura, Masaya organization: Department of Orthopedic Surgery, Keio University Graduate School of Medicine – sequence: 3 givenname: Francois orcidid: 0000-0002-7105-7317 surname: Renault-Mihara fullname: Renault-Mihara, Francois email: frenaultpro@yahoo.fr organization: Department of Physiology, Keio University Graduate School of Medicine – sequence: 4 givenname: Hideyuki orcidid: 0000-0001-7482-5935 surname: Okano fullname: Okano, Hideyuki organization: Department of Physiology, Keio University Graduate School of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31845093$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kc1u1DAUhS3Uik4LL8ACWWLDJtQ_ceIsR6MClTpqxY9YRnecm05GGTvYTlFY8QzwJjwID9EnqYcpRWLBwrLk891zdH2OyYF1Fgl5xtkrzlh5GrhgUmWMV-loxbPpEZlxpaqMcy0OyIzpSmZlkesjchzChjEhOCsfkyPJda5YJWfk-5XrwXdfIXbOUtfSdwgmdjdI5yF6Z6aIgXY2PYfB2YA0Ovp-6Cz0dOF8Q8_tZvQT7QI9s2uwBhu6muhS0CUY74Y1XOPttx9LbDqISZvvvB-yPtl4-utntkiSTRlXENdfYHpCDlvoAz69v0_Ix9dnHxZvs4vLN-eL-UVmZKli2pGBxFK1GlYIrGkBpMiZgaIwRraCo6wYV0yWZYVto3XOeJFXbVMII1atkCfk5d538O7ziCHW2y4Y7Huw6MZQCynKKudFUSb0xT_oxo0-fcKO0krpvFA7Q7Gn0uYheGzrwXdb8FPNWb1rrN43VqfG6t-N1VMaen5vPa622DyM_KkoAXIPhCTZa_R_s_9jewclg6X6 |
| CitedBy_id | crossref_primary_10_3390_brainsci12060708 crossref_primary_10_1089_neu_2020_7075 crossref_primary_10_1002_mco2_160 crossref_primary_10_3389_fncel_2020_00078 crossref_primary_10_17816_KMJ601864 crossref_primary_10_1016_j_jcot_2022_101760 crossref_primary_10_1186_s12951_024_02607_0 crossref_primary_10_1002_smll_202201957 crossref_primary_10_1002_glia_24378 crossref_primary_10_3390_cells11193143 crossref_primary_10_1007_s12035_021_02355_4 crossref_primary_10_1155_2020_9494352 crossref_primary_10_1186_s12974_021_02168_1 crossref_primary_10_1159_000526690 crossref_primary_10_1177_20587392211059362 crossref_primary_10_1007_s12035_024_04055_1 crossref_primary_10_1016_j_pharmthera_2021_107984 |
| Cites_doi | 10.1371/journal.pone.0078128 10.1002/glia.22885 10.1038/s41398-019-0542-2 10.18632/oncotarget.11552 10.1016/j.yexcr.2009.10.012 10.1080/01616412.2018.1517995 10.1002/emmm.201100179 10.1089/neu.2013.3067 10.1016/j.isci.2019.02.029 10.1016/S0092-8674(01)00471-8 10.1155/2017/7189421 10.1523/jneurosci.1709-08.2008 10.1242/dev.050070 10.1126/sciadv.aav5086 10.1046/j.1523-1755.2003.00767.x 10.1186/s12974-019-1489-1 10.1634/stemcells.2007-0177 10.1371/journal.pone.0098698 10.1523/jneurosci.2121-13.2013 10.1016/j.expneurol.2015.03.020 10.1038/nm1425 10.1038/mt.2015.46 10.1523/jneurosci.3547-03.2004 10.1021/jm400159c 10.1016/j.molmet.2014.03.004 10.1038/nchembio.137 10.3892/mmr.2014.1937 10.1523/jneurosci.3257-09.2009 10.1083/jcb.201610102 10.7554/eLife.11621 |
| ContentType | Journal Article |
| Copyright | Springer Science+Business Media, LLC, part of Springer Nature 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019. |
| Copyright_xml | – notice: Springer Science+Business Media, LLC, part of Springer Nature 2019 – notice: Springer Science+Business Media, LLC, part of Springer Nature 2019. |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QR 7TK 7X7 7XB 88A 88E 88G 88I 8AO 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2M M2P M7P P64 PQEST PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 |
| DOI | 10.1007/s12035-019-01851-y |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Chemoreception Abstracts Neurosciences Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) Medical Database Psychology Database Science Database (ProQuest) Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest One Psychology ProQuest Central Student Technology Research Database ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection Chemoreception Abstracts ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE ProQuest One Psychology |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1559-1182 |
| EndPage | 1862 |
| ExternalDocumentID | 10_1007_s12035_019_01851_y 31845093 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: Ministry of Education, Culture, Sports, Science and Technology grantid: WakateB #22700342; WakateB#16K21360 funderid: http://dx.doi.org/10.13039/501100001700 – fundername: Ministry of Education, Culture, Sports, Science and Technology grantid: WakateB#16K21360 – fundername: Ministry of Education, Culture, Sports, Science and Technology grantid: WakateB #22700342 |
| GroupedDBID | --- -4W -56 -5G -BR -EM -Y2 -~C -~X .86 .GJ .VR 06C 06D 0R~ 0VY 123 1N0 2.D 203 28- 29M 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2VQ 2~H 30V 3SX 3V. 4.4 406 408 40D 40E 53G 5VS 67N 6NX 78A 7X7 88A 88E 88I 8AO 8CJ 8FE 8FH 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AABYN AAFGU AAHNG AAIAL AAJKR AANXM AANZL AAPBV AARHV AARTL AATNV AATVU AAUYE AAWCG AAYFA AAYIU AAYQN AAYTO ABDZT ABECU ABELW ABFGW ABFTV ABHLI ABHQN ABIVO ABJNI ABJOX ABKAS ABKCH ABMNI ABMQK ABNWP ABPLI ABQBU ABSXP ABTEG ABTHY ABTKH ABTMW ABUWG ABWNU ABXPI ACBMV ACBRV ACBXY ACBYP ACCUX ACGFS ACGOD ACHSB ACHXU ACIGE ACIPQ ACIWK ACKNC ACMDZ ACMLO ACOKC ACOMO ACPRK ACTTH ACVWB ACWMK ADBBV ADHHG ADHIR ADINQ ADKNI ADKPE ADMDM ADOAH ADOJD ADOXG ADRFC ADTPH ADURQ ADYFF ADYPR ADZKW AEBTG AEEQQ AEFTE AEGAL AEGNC AEJHL AEJRE AEKMD AENEX AEOHA AEPYU AESKC AESTI AETLH AEVLU AEVTX AEXYK AFEXP AFGCZ AFKRA AFLOW AFNRJ AFQWF AFWTZ AFZKB AGAYW AGDGC AGGBP AGGDS AGJBK AGMZJ AGQMX AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHSBF AIAKS AIIXL AILAN AIMYW AITGF AJBLW AJDOV AJRNO AJZVZ AKMHD AKQUC ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG AOSHJ ARMRJ ASPBG AVWKF AXYYD AZFZN AZQEC B-. BA0 BBNVY BBWZM BDATZ BENPR BGNMA BHPHI BPHCQ BVXVI CAG CCPQU COF CS3 CSCUP D1J DDRTE DNIVK DPUIP DU5 DWQXO EBD EBLON EBS EIOEI EJD EMOBN ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNUQQ GNWQR GQ6 GQ7 HCIFZ HF~ HG6 HMCUK HMJXF HRMNR HVGLF HZ~ IJ- IKXTQ ITM IWAJR IXC I~X I~Z J-C J0Z JBSCW JZLTJ KDC KOV LK8 LLZTM M0L M1P M2M M2P M4Y M7P MA- N2Q N9A NDZJH NF0 NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OVD P19 P2P PF0 PQQKQ PROAC PSQYO PSYQQ PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RNI ROL RPX RSV RZK S16 S1Z S26 S27 S28 S3A S3B SAP SBL SBY SCLPG SDH SDM SHX SISQX SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZN T13 T16 TEORI TSG TUC U2A U9L UG4 UKHRP UNUBA UOJIU UTJUX UZXMN VC2 VFIZW W48 WK6 WK8 XJT YLTOR Z7U Z7V Z7W Z82 Z83 Z87 Z8O Z8V Z91 ZGI ZMTXR ZOVNA ~EX ~KM AACDK AAEOY AAJBT AAQLM AASML AAYZH ABAKF ACAOD ACDTI ACZOJ AEFQL AEMSY AFBBN AGQEE AGRTI AIGIU AIZAD ALIPV CGR CUY CVF ECM EIF H13 NPM SJYHP AAYXX CITATION 7QR 7TK 7XB 8FD 8FK FR3 K9. P64 PQEST PQUKI PRINS Q9U 7X8 |
| ID | FETCH-LOGICAL-c375t-110a3e75f8abea0dfaa3240ca66cc3f21e3901503779efd88401649fd62c2bf23 |
| IEDL.DBID | AGYKE |
| ISSN | 0893-7648 |
| IngestDate | Fri Oct 25 21:38:12 EDT 2024 Tue Nov 19 05:41:05 EST 2024 Thu Nov 21 23:51:16 EST 2024 Wed Oct 16 00:45:16 EDT 2024 Sat Dec 16 12:00:44 EST 2023 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Polarization Reactive astrocytes β-Catenin pathway Glial scar Macrophages Spinal cord injury Wnt |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c375t-110a3e75f8abea0dfaa3240ca66cc3f21e3901503779efd88401649fd62c2bf23 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-7105-7317 0000-0001-7482-5935 |
| PMID | 31845093 |
| PQID | 2385584652 |
| PQPubID | 55365 |
| PageCount | 16 |
| ParticipantIDs | proquest_miscellaneous_2327941667 proquest_journals_2385584652 crossref_primary_10_1007_s12035_019_01851_y pubmed_primary_31845093 springer_journals_10_1007_s12035_019_01851_y |
| PublicationCentury | 2000 |
| PublicationDate | 2020-04-01 |
| PublicationDateYYYYMMDD | 2020-04-01 |
| PublicationDate_xml | – month: 04 year: 2020 text: 2020-04-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: United States – name: Totowa |
| PublicationTitle | Molecular neurobiology |
| PublicationTitleAbbrev | Mol Neurobiol |
| PublicationTitleAlternate | Mol Neurobiol |
| PublicationYear | 2020 |
| Publisher | Springer US Springer Nature B.V |
| Publisher_xml | – name: Springer US – name: Springer Nature B.V |
| References | Zhang, Zheng, Bian, Liu, Xue, Liu, Yu, Zhang, Song, Chung, Ju, Wang (CR11) 2015; 23 Persy, Verhulst, Ysebaert, De Greef, De Broe (CR28) 2003; 63 Gracanin, Timmermans-Sprang, van Wolferen, Rao, Grizelj, Vince, Hellmen, Mol (CR19) 2014; 9 Wang, Moon, Dodge, Pan, Zhang, Hanson, Tuladhar, Ma, Shi, Williams, Amatruda, Carroll, Lum, Chen (CR17) 2013; 56 Cosin-Roger, Ortiz-Masia, Calatayud, Hernandez, Alvarez, Hinojosa, Esplugues, Barrachina (CR13) 2013; 8 Rivera, Butt (CR21) 2019; 9 Etienne-Manneville, Hall (CR6) 2001; 106 Adachi, Mirzadeh, Sakaguchi, Yamashita, Nikolcheva, Gotoh, Peltz, Gong, Kawase, Alvarez-Buylla, Okano, Sawamoto (CR9) 2007; 25 Burda, Bernstein, Sofroniew (CR1) 2016; 275 Kobayakawa, Ohkawa, Yoshizaki, Tamaru, Saito, Kijima, Yokota, Hara, Kubota, Matsumoto, Harimaya, Ozato, Masuda, Tsuda, Tamura, Inoue, Edgerton, Iwamoto, Nakashima, Okada (CR30) 2019; 5 Wu, Wang, Jiang, Hu, Chen, Zhang, Zhu, Liu, Li (CR22) 2014; 9 Kigerl, Gensel, Ankeny, Alexander, Donnelly, Popovich (CR12) 2009; 29 Faulkner, Herrmann, Woo, Tansey, Doan, Sofroniew (CR3) 2004; 24 Okada, Nakamura, Katoh, Miyao, Shimazaki, Ishii, Yamane, Yoshimura, Iwamoto, Toyama, Okano (CR4) 2006; 12 Gonzalez-Fernandez, Fernandez-Martos, Shields, Arenas, Javier Rodriguez (CR14) 2014; 31 Ladwig, Walter, Hucklenbroich, Willuweit, Langen, Fink, Rueger, Schroeter (CR27) 2017; 2017 Herrmann, Imura, Song, Qi, Ao, Nguyen, Korsak, Takeda, Akira, Sofroniew (CR5) 2008; 28 CR8 Wanner, Anderson, Song, Levine, Fernandez, Gray-Thompson, Ao, Sofroniew (CR2) 2013; 33 Stanganello, Zahavi, Burute, Smits, Jordens, Maurice, Kapitein, Hoogenraad (CR23) 2019; 13 Kahles, Findeisen, Bruemmer (CR24) 2014; 3 Robertson, Chellaiah (CR25) 2010; 316 Riew, Kim, Jin, Kim, Lee, Lee (CR26) 2019; 16 Rallis, Pinchin, Ish-Horowicz (CR15) 2010; 137 Gliem, Krammes, Liaw, van Rooijen, Hartung, Jander (CR7) 2015; 63 Renault-Mihara, Katoh, Ikegami, Iwanami, Mukaino, Yasuda, Nori, Mabuchi, Tada, Shibata, Saito, Matsushita, Kaibuchi, Okada, Toyama, Nakamura, Okano (CR10) 2011; 3 Ikeshima-Kataoka, Matsui, Uede (CR29) 2018; 40 CR20 Renner, Noulet, Mercier, Choulier, Etienne-Selloum, Gies, Lehmann, Lelong-Rebel, Martin, Dontenwill (CR16) 2016; 7 Chen, Dodge, Tang, Lu, Ma, Fan, Wei, Hao, Kilgore, Williams, Roth, Amatruda, Chen, Lum (CR18) 2009; 5 S Okada (1851_CR4) 2006; 12 C Rallis (1851_CR15) 2010; 137 A Gracanin (1851_CR19) 2014; 9 H Ikeshima-Kataoka (1851_CR29) 2018; 40 G Renner (1851_CR16) 2016; 7 TR Riew (1851_CR26) 2019; 16 VP Persy (1851_CR28) 2003; 63 IB Wanner (1851_CR2) 2013; 33 1851_CR20 F Kahles (1851_CR24) 2014; 3 K Kobayakawa (1851_CR30) 2019; 5 K Zhang (1851_CR11) 2015; 23 JE Herrmann (1851_CR5) 2008; 28 S Etienne-Manneville (1851_CR6) 2001; 106 A Ladwig (1851_CR27) 2017; 2017 X Wu (1851_CR22) 2014; 9 KA Kigerl (1851_CR12) 2009; 29 JE Burda (1851_CR1) 2016; 275 C Gonzalez-Fernandez (1851_CR14) 2014; 31 X Wang (1851_CR17) 2013; 56 1851_CR8 JR Faulkner (1851_CR3) 2004; 24 AD Rivera (1851_CR21) 2019; 9 F Renault-Mihara (1851_CR10) 2011; 3 J Cosin-Roger (1851_CR13) 2013; 8 E Stanganello (1851_CR23) 2019; 13 M Gliem (1851_CR7) 2015; 63 K Adachi (1851_CR9) 2007; 25 B Chen (1851_CR18) 2009; 5 BW Robertson (1851_CR25) 2010; 316 |
| References_xml | – volume: 8 issue: 10 year: 2013 ident: CR13 article-title: M2 macrophages activate WNT signaling pathway in epithelial cells: relevance in ulcerative colitis publication-title: PLoS One doi: 10.1371/journal.pone.0078128 contributor: fullname: Barrachina – volume: 63 start-page: 2198 issue: 12 year: 2015 end-page: 2207 ident: CR7 article-title: Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke publication-title: Glia doi: 10.1002/glia.22885 contributor: fullname: Jander – volume: 9 start-page: 211 issue: 1 year: 2019 ident: CR21 article-title: Astrocytes are direct cellular targets of lithium treatment: novel roles for lysyl oxidase and peroxisome-proliferator activated receptor-gamma as astroglial targets of lithium publication-title: Transl Psychiatry doi: 10.1038/s41398-019-0542-2 contributor: fullname: Butt – volume: 7 start-page: 62194 issue: 38 year: 2016 end-page: 62207 ident: CR16 article-title: Expression/activation of alpha5beta1 integrin is linked to the beta-catenin signaling pathway to drive migration in glioma cells publication-title: Oncotarget doi: 10.18632/oncotarget.11552 contributor: fullname: Dontenwill – volume: 316 start-page: 1 issue: 1 year: 2010 end-page: 11 ident: CR25 article-title: Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2009.10.012 contributor: fullname: Chellaiah – volume: 40 start-page: 1071 issue: 12 year: 2018 end-page: 1079 ident: CR29 article-title: Osteopontin is indispensable for activation of astrocytes in injured mouse brain and primary culture publication-title: Neurol Res doi: 10.1080/01616412.2018.1517995 contributor: fullname: Uede – volume: 3 start-page: 682 issue: 11 year: 2011 end-page: 696 ident: CR10 article-title: Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition publication-title: EMBO Mol Med doi: 10.1002/emmm.201100179 contributor: fullname: Okano – volume: 31 start-page: 565 issue: 6 year: 2014 end-page: 581 ident: CR14 article-title: Wnts are expressed in the spinal cord of adult mice and are differentially induced after injury publication-title: J Neurotrauma doi: 10.1089/neu.2013.3067 contributor: fullname: Javier Rodriguez – volume: 13 start-page: 318 year: 2019 end-page: 327 ident: CR23 article-title: Wnt signaling directs neuronal polarity and axonal growth publication-title: iScience doi: 10.1016/j.isci.2019.02.029 contributor: fullname: Hoogenraad – volume: 106 start-page: 489 issue: 4 year: 2001 end-page: 498 ident: CR6 article-title: Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta publication-title: Cell doi: 10.1016/S0092-8674(01)00471-8 contributor: fullname: Hall – ident: CR8 – volume: 2017 start-page: 7189421 year: 2017 ident: CR27 article-title: Osteopontin augments M2 microglia response and separates M1- and M2-polarized microglial activation in permanent focal cerebral ischemia publication-title: Mediat Inflamm doi: 10.1155/2017/7189421 contributor: fullname: Schroeter – volume: 28 start-page: 7231 issue: 28 year: 2008 end-page: 7243 ident: CR5 article-title: STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury publication-title: J Neurosci doi: 10.1523/jneurosci.1709-08.2008 contributor: fullname: Sofroniew – volume: 137 start-page: 3591 issue: 21 year: 2010 end-page: 3601 ident: CR15 article-title: Cell-autonomous integrin control of Wnt and Notch signalling during somitogenesis publication-title: Development doi: 10.1242/dev.050070 contributor: fullname: Ish-Horowicz – volume: 5 start-page: eaav5086 issue: 5 year: 2019 ident: CR30 article-title: Macrophage centripetal migration drives spontaneous healing process after spinal cord injury publication-title: Science Adv doi: 10.1126/sciadv.aav5086 contributor: fullname: Okada – volume: 63 start-page: 543 issue: 2 year: 2003 end-page: 553 ident: CR28 article-title: Reduced postischemic macrophage infiltration and interstitial fibrosis in osteopontin knockout mice publication-title: Kidney Int doi: 10.1046/j.1523-1755.2003.00767.x contributor: fullname: De Broe – volume: 16 start-page: 99 issue: 1 year: 2019 ident: CR26 article-title: Osteopontin and its spatiotemporal relationship with glial cells in the striatum of rats treated with mitochondrial toxin 3-nitropropionic acid: possible involvement in phagocytosis publication-title: J Neuroinflammation doi: 10.1186/s12974-019-1489-1 contributor: fullname: Lee – volume: 25 start-page: 2827 issue: 11 year: 2007 end-page: 2836 ident: CR9 article-title: Beta-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone publication-title: Stem Cells doi: 10.1634/stemcells.2007-0177 contributor: fullname: Sawamoto – volume: 9 start-page: e98698 issue: 6 year: 2014 ident: CR19 article-title: Ligand-independent canonical Wnt activity in canine mammary tumor cell lines associated with aberrant LEF1 expression publication-title: PLoS One doi: 10.1371/journal.pone.0098698 contributor: fullname: Mol – volume: 33 start-page: 12870 issue: 31 year: 2013 end-page: 12886 ident: CR2 article-title: Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury publication-title: J Neurosci doi: 10.1523/jneurosci.2121-13.2013 contributor: fullname: Sofroniew – volume: 275 start-page: 305 issue: Pt 3 year: 2016 end-page: 315 ident: CR1 article-title: Astrocyte roles in traumatic brain injury publication-title: Exp Neurol doi: 10.1016/j.expneurol.2015.03.020 contributor: fullname: Sofroniew – volume: 12 start-page: 829 issue: 7 year: 2006 end-page: 834 ident: CR4 article-title: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury publication-title: Nat Med doi: 10.1038/nm1425 contributor: fullname: Okano – volume: 23 start-page: 1077 issue: 6 year: 2015 end-page: 1091 ident: CR11 article-title: Polarized macrophages have distinct roles in the differentiation and migration of embryonic spinal-cord-derived neural stem cells after grafting to injured sites of spinal cord publication-title: Mol Ther doi: 10.1038/mt.2015.46 contributor: fullname: Wang – volume: 24 start-page: 2143 issue: 9 year: 2004 end-page: 2155 ident: CR3 article-title: Reactive astrocytes protect tissue and preserve function after spinal cord injury publication-title: J Neurosci doi: 10.1523/jneurosci.3547-03.2004 contributor: fullname: Sofroniew – volume: 56 start-page: 2700 issue: 6 year: 2013 end-page: 2704 ident: CR17 article-title: The development of highly potent inhibitors for porcupine publication-title: J Med Chem doi: 10.1021/jm400159c contributor: fullname: Chen – volume: 3 start-page: 384 issue: 4 year: 2014 end-page: 393 ident: CR24 article-title: Osteopontin: a novel regulator at the cross roads of inflammation, obesity and diabetes publication-title: Molecular metabolism doi: 10.1016/j.molmet.2014.03.004 contributor: fullname: Bruemmer – volume: 5 start-page: 100 issue: 2 year: 2009 end-page: 107 ident: CR18 article-title: Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer publication-title: Nat Chem Biol doi: 10.1038/nchembio.137 contributor: fullname: Lum – volume: 9 start-page: 1159 issue: 4 year: 2014 end-page: 1164 ident: CR22 article-title: Wnt3a activates beta1-integrin and regulates migration and adhesion of vascular smooth muscle cells publication-title: Mol Med Rep doi: 10.3892/mmr.2014.1937 contributor: fullname: Li – volume: 29 start-page: 13435 issue: 43 year: 2009 end-page: 13444 ident: CR12 article-title: Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord publication-title: J Neurosci doi: 10.1523/jneurosci.3257-09.2009 contributor: fullname: Popovich – ident: CR20 – volume: 3 start-page: 682 issue: 11 year: 2011 ident: 1851_CR10 publication-title: EMBO Mol Med doi: 10.1002/emmm.201100179 contributor: fullname: F Renault-Mihara – volume: 40 start-page: 1071 issue: 12 year: 2018 ident: 1851_CR29 publication-title: Neurol Res doi: 10.1080/01616412.2018.1517995 contributor: fullname: H Ikeshima-Kataoka – volume: 3 start-page: 384 issue: 4 year: 2014 ident: 1851_CR24 publication-title: Molecular metabolism doi: 10.1016/j.molmet.2014.03.004 contributor: fullname: F Kahles – volume: 33 start-page: 12870 issue: 31 year: 2013 ident: 1851_CR2 publication-title: J Neurosci doi: 10.1523/jneurosci.2121-13.2013 contributor: fullname: IB Wanner – ident: 1851_CR8 doi: 10.1083/jcb.201610102 – volume: 23 start-page: 1077 issue: 6 year: 2015 ident: 1851_CR11 publication-title: Mol Ther doi: 10.1038/mt.2015.46 contributor: fullname: K Zhang – volume: 275 start-page: 305 issue: Pt 3 year: 2016 ident: 1851_CR1 publication-title: Exp Neurol doi: 10.1016/j.expneurol.2015.03.020 contributor: fullname: JE Burda – volume: 12 start-page: 829 issue: 7 year: 2006 ident: 1851_CR4 publication-title: Nat Med doi: 10.1038/nm1425 contributor: fullname: S Okada – ident: 1851_CR20 doi: 10.7554/eLife.11621 – volume: 5 start-page: eaav5086 issue: 5 year: 2019 ident: 1851_CR30 publication-title: Science Adv doi: 10.1126/sciadv.aav5086 contributor: fullname: K Kobayakawa – volume: 29 start-page: 13435 issue: 43 year: 2009 ident: 1851_CR12 publication-title: J Neurosci doi: 10.1523/jneurosci.3257-09.2009 contributor: fullname: KA Kigerl – volume: 2017 start-page: 7189421 year: 2017 ident: 1851_CR27 publication-title: Mediat Inflamm doi: 10.1155/2017/7189421 contributor: fullname: A Ladwig – volume: 8 issue: 10 year: 2013 ident: 1851_CR13 publication-title: PLoS One doi: 10.1371/journal.pone.0078128 contributor: fullname: J Cosin-Roger – volume: 13 start-page: 318 year: 2019 ident: 1851_CR23 publication-title: iScience doi: 10.1016/j.isci.2019.02.029 contributor: fullname: E Stanganello – volume: 25 start-page: 2827 issue: 11 year: 2007 ident: 1851_CR9 publication-title: Stem Cells doi: 10.1634/stemcells.2007-0177 contributor: fullname: K Adachi – volume: 31 start-page: 565 issue: 6 year: 2014 ident: 1851_CR14 publication-title: J Neurotrauma doi: 10.1089/neu.2013.3067 contributor: fullname: C Gonzalez-Fernandez – volume: 63 start-page: 543 issue: 2 year: 2003 ident: 1851_CR28 publication-title: Kidney Int doi: 10.1046/j.1523-1755.2003.00767.x contributor: fullname: VP Persy – volume: 9 start-page: 1159 issue: 4 year: 2014 ident: 1851_CR22 publication-title: Mol Med Rep doi: 10.3892/mmr.2014.1937 contributor: fullname: X Wu – volume: 5 start-page: 100 issue: 2 year: 2009 ident: 1851_CR18 publication-title: Nat Chem Biol doi: 10.1038/nchembio.137 contributor: fullname: B Chen – volume: 63 start-page: 2198 issue: 12 year: 2015 ident: 1851_CR7 publication-title: Glia doi: 10.1002/glia.22885 contributor: fullname: M Gliem – volume: 28 start-page: 7231 issue: 28 year: 2008 ident: 1851_CR5 publication-title: J Neurosci doi: 10.1523/jneurosci.1709-08.2008 contributor: fullname: JE Herrmann – volume: 56 start-page: 2700 issue: 6 year: 2013 ident: 1851_CR17 publication-title: J Med Chem doi: 10.1021/jm400159c contributor: fullname: X Wang – volume: 7 start-page: 62194 issue: 38 year: 2016 ident: 1851_CR16 publication-title: Oncotarget doi: 10.18632/oncotarget.11552 contributor: fullname: G Renner – volume: 9 start-page: 211 issue: 1 year: 2019 ident: 1851_CR21 publication-title: Transl Psychiatry doi: 10.1038/s41398-019-0542-2 contributor: fullname: AD Rivera – volume: 137 start-page: 3591 issue: 21 year: 2010 ident: 1851_CR15 publication-title: Development doi: 10.1242/dev.050070 contributor: fullname: C Rallis – volume: 106 start-page: 489 issue: 4 year: 2001 ident: 1851_CR6 publication-title: Cell doi: 10.1016/S0092-8674(01)00471-8 contributor: fullname: S Etienne-Manneville – volume: 24 start-page: 2143 issue: 9 year: 2004 ident: 1851_CR3 publication-title: J Neurosci doi: 10.1523/jneurosci.3547-03.2004 contributor: fullname: JR Faulkner – volume: 316 start-page: 1 issue: 1 year: 2010 ident: 1851_CR25 publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2009.10.012 contributor: fullname: BW Robertson – volume: 16 start-page: 99 issue: 1 year: 2019 ident: 1851_CR26 publication-title: J Neuroinflammation doi: 10.1186/s12974-019-1489-1 contributor: fullname: TR Riew – volume: 9 start-page: e98698 issue: 6 year: 2014 ident: 1851_CR19 publication-title: PLoS One doi: 10.1371/journal.pone.0098698 contributor: fullname: A Gracanin |
| SSID | ssj0022107 |
| Score | 2.4263296 |
| Snippet | Understanding the mechanisms of glial scar formation by reactive astrocytes is crucial for elaborating a therapeutic strategy to brain and spinal cord injury.... |
| SourceID | proquest crossref pubmed springer |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 1847 |
| SubjectTerms | Animals Astrocytes Astrocytes - metabolism Astrocytes - pathology Biomedical and Life Sciences Biomedicine Brain injury Cell activation Cell Biology Cell Polarity Chemotaxis Integrin beta1 - metabolism Interleukin 4 Macrophage Activation Macrophages Mice, Inbred C57BL Neurobiology Neurology Neurosciences Polarization Spinal cord injuries Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology Wnt protein Wnt Signaling Pathway Wnt3A Protein - metabolism β-Catenin |
| SummonAdditionalLinks | – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NbtQwELZKe-GCoOUnpVSDhLiA1V3bcZITWq1aFaStKtqKvUWOf9Qi4WzZVCi3PkN5Ex6Eh-BJGDtJV6ii1ziKrXz2_HlmPkLeVIVCo78oqDBWUsENykFRMeoyZlnKslFHnTA7kodn4tM8nfcBt2WfVjnIxCioTa1DjHwPVUsalGXKPiwuaWCNCrerPYXGA7IxZqjKcT9n85XDhe5M1-mz4DSTIu-LZrrSORaaNY5CCQ-qrDFt_1VMd6zNOzelUQEdPCaPessRJh3UT8ia9Ztka-LRa_7WwluIuZwxSL5Fbo6Dx9qXWELt4LNVUbDBZNmgymrRwIQLj49jhqyFpoaTRSDIgil6o_DRf8V_DRdL2PfnMUcAqhZmDGYqUH6doxD6c_1zFmk-cGyiB5K0MNcX3-z9_kWnOORxjmO0MX-o9ik5O9g_nR7Snn2Bap6lDUW7QHGbpS5XlVUj45QKzfu0klJr7tjYduGS0LHQOpOjp4iuV-GMZJpVjvFnZN3X3r4g4ETutDEjpnOEvmKqcI5XzqhCpFxqkZB3w68vF12TjXLVTjkAVSJQZQSqbBOyM6BT9gduWa62R0Je3w7jUQn3H8rb-iq8w1D6jKXMEvK8Q_V2OhRtAm0nnpD3A8yrj_9_Ldv3r-UleciCfx4zfXbIevP9yr5CI6apduNO_QucP--- priority: 102 providerName: ProQuest |
| Title | Polarization of Reactive Astrocytes in Response to Spinal Cord Injury is Enhanced by M2 Macrophage–Mediated Activation of Wnt/β-Catenin Pathway |
| URI | https://link.springer.com/article/10.1007/s12035-019-01851-y https://www.ncbi.nlm.nih.gov/pubmed/31845093 https://www.proquest.com/docview/2385584652 https://search.proquest.com/docview/2327941667 |
| Volume | 57 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3NbtQwEB7R9sKFAuUntFRGQlwgZddOnOQYVlsKaKtV6YrlFNmOrZYKb9XNCoUTzwBvwoPwEDwJYyfZFVo49BTJtuLE45n5xp4fgKcyEwj6syyMSs3DiJUoByNJQ5NQTWOa9JrSCaNjfjSJ3k7j6SqO2zu7dzeSXlCvYt2oy67YczE3qGP6Yb0BW6h7HDdu5a8_vhsu7Sy0YpoEnxkLEx6lbazMv9_ytz5aA5lrF6Re7xxuw2kXvdO4m1wcLCp5oL6uJ3O8zi_dhlstDiV5s3HuwA1t78JObtEG_1yTZ8R7hvoj9x34Pnb2bxuwSWaGnGjhxSTJ5xUqwBrhKjm32Oz9bTWpZuT9pSu3RQZo25I39hNSjpzPydCeeY8DImsyomQkXAGxMxRpv7_9GPmiIdiXq67kmpvrg61e_voZDrDL4hxjRKxfRH0PJofD08FR2NZyCBVL4ipElCGYTmKTCqlFrzRCuFSASnCuFDO0r5vDF5f_UJsyRbsTDbnMlJwqKg1l92HTzqx-CMREqVFl2aMqxY0kqciMYdKUIotixlUUwPOOosVlk7KjWCVndkte4JIXfsmLOoC9juhFy77zAnFM7JBZTAN4suxGxnO3KcLq2cKNoSjL-pwnATxoNstyOhSUESIxFsCLjvKrl___Wx5db_gu3KTO-vd-RHuwWV0t9GOESJXch41kmuy3jIHPV8Pj8Qm2Tmj-B-fTDOQ |
| link.rule.ids | 314,780,784,12056,21388,27924,27925,31719,31720,33744,33745,41081,41523,42150,42592,43310,43805,52111,52234,73745,74302 |
| linkProvider | Springer Nature |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3BbtQwEB3B9gAXBBRoSgEjIS5gdddJnOSEltVWW2hWq9KK3iLHsdUi1VnYVCg3vgH-hA_hI_gSxo6zK1TBNY5iK2PPzBvPzAN4UWYCnf4so1GlOI3CCvVgVDKqE6ZYzJJhR52Qz_nsNHp3Fp_5gNvKp1X2OtEp6qqWNka-j6YltsYyZm-Wn6lljbK3q55C4yZs2c7p8QC23k7ni-M15EJA0_X6zEKa8Cj1ZTNd8Ryz7RqHtogHjdaItn-bpmv-5rW7UmeCDu7CHe87knEn7HtwQ5n7sD02iJsvW_KSuGxOFybfhu8Li1l9kSWpNTlWwqk2Ml41aLRadDHJhcHHLkdWkaYmH5aWIotMEI-SQ_MJ_za5WJGpOXdZAqRsSc5ILizp1zmqod_ffuSO6APHxrKnSbNzfTTN_q-fdIJDBudYoJf5VbQP4PRgejKZUc-_QGWYxA1Fz0CEKol1KkolhpUWwrbvk4JzKUPNRqoLmNiehUpXKWJFBF-ZrjiTrNQsfAgDUxu1A0RHqZZVNWQyReGXTGRah6WuRBbFIZdRAK_6X18suzYbxaahshVUgYIqnKCKNoC9XjqFP3KrYrNBAni-HsbDYm9AhFH1lX2Hof4ZcZ4E8KiT6no6VG4Rek9hAK97MW8-_u-17P5_Lc_g1uwkPyqODufvH8NtZtG6y_vZg0Hz5Uo9QZemKZ_6ffsHI230FA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dbtMwFD6CTkLcIGD8ZAwwEuIGrKZ2fq9QKa02oFU1mNhd5Di2NiScjmZCueMZ4E14EB6CJ-HYcVqhCW7jKLZyjs_5Pvv8ADwtc4GgP89pVKmERrxCOxiVjOqUKRazNOxaJ8wXycFx9OYkPvHxT2sfVtnbRGeoq1raM_IhupbYOsuYDbUPi1i-nr1cnVPbQcretPp2GldhB71iyAaw82q6WB5t6BeSm67uZ85pmkSZT6HpEumYLd0Y2oQedGAj2v7tpi5hz0v3ps4dzW7CDY8jybgT_C24osxt2B0b5NCfW_KMuMhOd2S-C9-Xlr_6hEtSa3KkhDNzZLxu0IG1CDfJmcHHLl5WkaYm71e2XRaZIDclh-YT_nlytiZTc-oiBkjZkjkjc2EbgJ2iSfr97cfcNf3AsbHsW6bZuT6aZvjrJ53gkME5log4v4r2DhzPph8mB9T3YqCSp3FDESUIrtJYZ6JUIqy0ELaUnxRJIiXXbKS6wxNbv1DpKkPeiEQs11XCJCs143dhYGqj7gPRUaZlVYVMZqgIJRO51rzUlcijmCcyCuB5_-uLVVdyo9gWV7aCKlBQhRNU0Qaw30un8NtvXWyVJYAnm2HcOPY2RBhVX9h3GNqiUZKkAdzrpLqZDg1dhEiKB_CiF_P24_9ey97_1_IYrqHKFu8OF28fwHVmibsLAdqHQfPlQj1EdNOUj7za_gF6mvhB |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Polarization+of+Reactive+Astrocytes+in+Response+to+Spinal+Cord+Injury+is+Enhanced+by+M2+Macrophage-Mediated+Activation+of+Wnt%2F%CE%B2-Catenin+Pathway&rft.jtitle=Molecular+neurobiology&rft.au=Sonn%2C+Iki&rft.au=Nakamura%2C+Masaya&rft.au=Renault-Mihara%2C+Francois&rft.au=Okano%2C+Hideyuki&rft.date=2020-04-01&rft.eissn=1559-1182&rft.volume=57&rft.issue=4&rft.spage=1847&rft_id=info:doi/10.1007%2Fs12035-019-01851-y&rft_id=info%3Apmid%2F31845093&rft.externalDocID=31845093 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0893-7648&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0893-7648&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0893-7648&client=summon |