Porphyromonas gingivalis Promotes Colorectal Carcinoma by Activating the Hematopoietic NLRP3 Inflammasome

• Published in: Cancer research (Chicago, Ill.) Vol. 81; no. 10; pp. 2745 - 2759
• Main Authors: Wang, Xi, Jia, Yiqun, Wen, Liling, Mu, Wenxin, Wu, Xianrui, Liu, Tao, Liu, Xiangqi, Fang, Juan, Luan, Yizhao, Chen, Ping, Gao, Jinlong, Nguyen, Ky-Anh, Cui, Jun, Zeng, Gucheng, Lan, Ping, Chen, Qianming, Cheng, Bin, Wang, Zhi
• Format: Journal Article
• Language: English
• Published: United States 15.05.2021
• Subjects: Animals; Apoptosis; Bacteroidaceae Infections - complications; Bacteroidaceae Infections - immunology; Bacteroidaceae Infections - microbiology; Bacteroidaceae Infections - pathology; Carcinogenesis - immunology; Carcinogenesis - metabolism; Carcinogenesis - pathology; Cell Proliferation; Colorectal Neoplasms - immunology; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - microbiology; Colorectal Neoplasms - pathology; Gene Expression Regulation, Neoplastic; Humans; Inflammasomes - immunology; Inflammasomes - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Myeloid Cells - immunology; Myeloid Cells - metabolism; Myeloid Cells - microbiology; Myeloid Cells - pathology; Neoplastic Stem Cells - immunology; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - microbiology; Neoplastic Stem Cells - pathology; NLR Family, Pyrin Domain-Containing 3 Protein - physiology; Porphyromonas gingivalis - pathogenicity; Prognosis; Survival Rate; Tumor Cells, Cultured; Tumor Microenvironment - immunology; Xenograft Model Antitumor Assays

( ) is a keystone periodontal pathogen associated with various digestive cancers. However, whether can promote colorectal cancer and the underlying mechanism associated with such promotion remains unclear. In this study, we found that was enriched in human feces and tissue samples from patients with...