Extracellular vesicle-transmitted miR-671-5p alleviates lung inflammation and injury by regulating the AAK1/NF-κB axis

• Published in: Molecular therapy Vol. 31; no. 5; pp. 1365 - 1382
• Main Authors: Lian, Jie, Zhu, Xinxing, Du, Jiang, Huang, Beijia, Zhao, Fengting, Ma, Chunya, Guo, Rui, Zhang, Yangxia, Ji, Longkai, Yahaya, Badrul Hisham, Lin, Juntang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.05.2023; American Society of Gene & Cell Therapy
• Subjects: AAK1; extracellular vesicles; Extracellular Vesicles - genetics; Extracellular Vesicles - metabolism; Humans; Inflammation - genetics; Inflammation - metabolism; Inflammation - therapy; Lipopolysaccharides - pharmacology; Lung Injury; menstrual blood-derived stem cells; MicroRNAs - genetics; MicroRNAs - metabolism; miR-671-5p; NF-kappa B - genetics; NF-kappa B - metabolism; NF-κB signaling; Original; Pneumonia - genetics; Pneumonia - therapy; Protein Serine-Threonine Kinases; pulmonary inflammatory injury; pulmonary inflammatory injury; NF-κB signaling; AAK1; menstrual blood-derived stem cells; extracellular vesicles; miR-671-5p

Mesenchymal stem cells regulate remote intercellular signaling communication via their secreted extracellular vesicles. Here, we report that menstrual blood-derived stem cells alleviate acute lung inflammation and injury via their extracellular vesicle-transmitted miR-671-5p. Disruption of this abun...