Correlates of Adiponectin in Hepatitis C–Infected Children: The Importance of Body Mass Index
OBJECTIVES:Adiponectin is a regulator of cytokines that, in turn, play a vital role in inflammatory and immune responses. Adiponectin is therefore likely to have a contributory role in hepatitis C virus (HCV) infection. We sought to characterize adiponectin levels and examine correlates in a pediatr...
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Published in | Journal of pediatric gastroenterology and nutrition Vol. 60; no. 2; pp. 165 - 170 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology
01.02.2015
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Abstract | OBJECTIVES:Adiponectin is a regulator of cytokines that, in turn, play a vital role in inflammatory and immune responses. Adiponectin is therefore likely to have a contributory role in hepatitis C virus (HCV) infection. We sought to characterize adiponectin levels and examine correlates in a pediatric HCV-infected cohort.
METHODS:We performed a cross-sectional study in children (5–17 years of age, n = 86) in the Pediatric Study of Hepatitis C (PEDS-C) trial. Adiponectin levels were univariately correlated with patient demographics, anthropometrics, and viral and histological measures. Multivariate regression models were used to identify the unique (ie, nonconfounded) associations with adiponectin concentrations.
RESULTS:Body mass index (BMI) had the highest univariate inverse correlation with loge adiponectin (r = −0.5, P < 0.0001). In multivariate analysis, BMI remained inversely correlated with loge adiponectin after accounting for age and route of HCV transmission (r = −0.38, P = 0.0003). Steatosis and fibrosis were inversely related to loge adiponectin in univariate analysis, but these associations were not statistically significant after multivariate adjustments (P ≥ 0.1827).
CONCLUSIONS:High BMI among HCV-infected children is associated with lower adiponectin levels. Practitioners should be cognizant of the possible risks of low adiponectin when managing HCV-infected children who are overweight. Further studies are indicated to determine the impact of having low adiponectin on HCV infection in youth. |
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AbstractList | Adiponectin is a regulator of cytokines that, in turn, play a vital role in inflammatory and immune responses. Adiponectin is therefore likely to have a contributory role in hepatitis C virus (HCV) infection. We sought to characterize adiponectin levels and examine correlates in a pediatric HCV-infected cohort.
We performed a cross-sectional study in children (5-17 years of age, n = 86) in the Pediatric Study of Hepatitis C (PEDS-C) trial. Adiponectin levels were univariately correlated with patient demographics, anthropometrics, and viral and histological measures. Multivariate regression models were used to identify the unique (ie, nonconfounded) associations with adiponectin concentrations.
Body mass index (BMI) had the highest univariate inverse correlation with log(e) adiponectin (r = -0.5, P < 0.0001). In multivariate analysis, BMI remained inversely correlated with log(e) adiponectin after accounting for age and route of HCV transmission (r = -0.38, P = 0.0003). Steatosis and fibrosis were inversely related to log(e) adiponectin in univariate analysis, but these associations were not statistically significant after multivariate adjustments (P ≥ 0.1827).
High BMI among HCV-infected children is associated with lower adiponectin levels. Practitioners should be cognizant of the possible risks of low adiponectin when managing HCV-infected children who are overweight. Further studies are indicated to determine the impact of having low adiponectin on HCV infection in youth. OBJECTIVESAdiponectin is a regulator of cytokines that, in turn, play a vital role in inflammatory and immune responses. Adiponectin is therefore likely to have a contributory role in hepatitis C virus (HCV) infection. We sought to characterize adiponectin levels and examine correlates in a pediatric HCV-infected cohort.METHODSWe performed a cross-sectional study in children (5-17 years of age, n = 86) in the Pediatric Study of Hepatitis C (PEDS-C) trial. Adiponectin levels were univariately correlated with patient demographics, anthropometrics, and viral and histological measures. Multivariate regression models were used to identify the unique (ie, nonconfounded) associations with adiponectin concentrations.RESULTSBody mass index (BMI) had the highest univariate inverse correlation with log(e) adiponectin (r = -0.5, P < 0.0001). In multivariate analysis, BMI remained inversely correlated with log(e) adiponectin after accounting for age and route of HCV transmission (r = -0.38, P = 0.0003). Steatosis and fibrosis were inversely related to log(e) adiponectin in univariate analysis, but these associations were not statistically significant after multivariate adjustments (P ≥ 0.1827).CONCLUSIONSHigh BMI among HCV-infected children is associated with lower adiponectin levels. Practitioners should be cognizant of the possible risks of low adiponectin when managing HCV-infected children who are overweight. Further studies are indicated to determine the impact of having low adiponectin on HCV infection in youth. OBJECTIVES:Adiponectin is a regulator of cytokines that, in turn, play a vital role in inflammatory and immune responses. Adiponectin is therefore likely to have a contributory role in hepatitis C virus (HCV) infection. We sought to characterize adiponectin levels and examine correlates in a pediatric HCV-infected cohort. METHODS:We performed a cross-sectional study in children (5–17 years of age, n = 86) in the Pediatric Study of Hepatitis C (PEDS-C) trial. Adiponectin levels were univariately correlated with patient demographics, anthropometrics, and viral and histological measures. Multivariate regression models were used to identify the unique (ie, nonconfounded) associations with adiponectin concentrations. RESULTS:Body mass index (BMI) had the highest univariate inverse correlation with loge adiponectin (r = −0.5, P < 0.0001). In multivariate analysis, BMI remained inversely correlated with loge adiponectin after accounting for age and route of HCV transmission (r = −0.38, P = 0.0003). Steatosis and fibrosis were inversely related to loge adiponectin in univariate analysis, but these associations were not statistically significant after multivariate adjustments (P ≥ 0.1827). CONCLUSIONS:High BMI among HCV-infected children is associated with lower adiponectin levels. Practitioners should be cognizant of the possible risks of low adiponectin when managing HCV-infected children who are overweight. Further studies are indicated to determine the impact of having low adiponectin on HCV infection in youth. |
Author | Negre, Betania Ludwig, David A Delgado-Borrego, Aymin Goodman, Zachary D Chung, Raymond T Jonas, Maureen M Raza, Roshan Gonzalez-Peralta, Regino P |
AuthorAffiliation | Department of Pediatrics, Batchelor Childrenʼs Research Institute, University of Miami Miller School of Medicine, Miami, FL †Division of Gastroenterology, Boston Childrenʼs Hospital ‡Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA §Division of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Florida College of Medicine, Gainesville, FL ||Armed Forces Institute of Pathology, Washington, DC |
AuthorAffiliation_xml | – name: Department of Pediatrics, Batchelor Childrenʼs Research Institute, University of Miami Miller School of Medicine, Miami, FL †Division of Gastroenterology, Boston Childrenʼs Hospital ‡Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA §Division of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Florida College of Medicine, Gainesville, FL ||Armed Forces Institute of Pathology, Washington, DC |
Author_xml | – sequence: 1 givenname: Aymin surname: Delgado-Borrego fullname: Delgado-Borrego, Aymin organization: Department of Pediatrics, Batchelor Childrenʼs Research Institute, University of Miami Miller School of Medicine, Miami, FL †Division of Gastroenterology, Boston Childrenʼs Hospital ‡Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA §Division of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Florida College of Medicine, Gainesville, FL ||Armed Forces Institute of Pathology, Washington, DC – sequence: 2 givenname: Regino surname: Gonzalez-Peralta middlename: P fullname: Gonzalez-Peralta, Regino P – sequence: 3 givenname: Roshan surname: Raza fullname: Raza, Roshan – sequence: 4 givenname: Betania surname: Negre fullname: Negre, Betania – sequence: 5 givenname: Zachary surname: Goodman middlename: D fullname: Goodman, Zachary D – sequence: 6 givenname: Maureen surname: Jonas middlename: M fullname: Jonas, Maureen M – sequence: 7 givenname: Raymond surname: Chung middlename: T fullname: Chung, Raymond T – sequence: 8 givenname: David surname: Ludwig middlename: A fullname: Ludwig, David A |
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Snippet | OBJECTIVES:Adiponectin is a regulator of cytokines that, in turn, play a vital role in inflammatory and immune responses. Adiponectin is therefore likely to... Adiponectin is a regulator of cytokines that, in turn, play a vital role in inflammatory and immune responses. Adiponectin is therefore likely to have a... OBJECTIVESAdiponectin is a regulator of cytokines that, in turn, play a vital role in inflammatory and immune responses. Adiponectin is therefore likely to... |
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SubjectTerms | Adiponectin - blood Adolescent Age Factors Body Mass Index Child Child, Preschool Cross-Sectional Studies Fatty Liver - blood Female Hepatitis C, Chronic - blood Hepatitis C, Chronic - transmission Humans Liver Cirrhosis - blood Male |
Title | Correlates of Adiponectin in Hepatitis C–Infected Children: The Importance of Body Mass Index |
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