Evolution of soft drusen in age-related macular degeneration
The pathways by which soft drusen are formed are illustrated by representative clinical and clinicopathological cases. One type is derived from small hard drusen which first tend to aggregate into clusters and then fuse, forming larger deposits termed hard clusters. Breakdown of the hard drusen resu...
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| Published in | Eye (London) Vol. 8; no. 3; pp. 269 - 283 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Basingstoke
Nature Publishing Group
01.01.1994
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The pathways by which soft drusen are formed are illustrated by representative clinical and clinicopathological cases. One type is derived from small hard drusen which first tend to aggregate into clusters and then fuse, forming larger deposits termed hard clusters. Breakdown of the hard drusen results in varying degrees of softening and confluence. These soft clusters may appear in middle age and, like the preceding hard drusen, remain a focal pathology. Soft clusters commonly lead to the atrophic form of age-related macular degeneration. Another type of soft drusen is formed from membranous debris as part of a diffuse disturbance of the retinal pigment epithelium. These membranous soft drusen first appear in the seventh decade and are commonly associated with choroidal neovascularisation. |
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| AbstractList | The pathways by which soft drusen are formed are illustrated by representative clinical and clinicopathological cases. One type is derived from small hard drusen which first tend to aggregate into clusters and then fuse, forming larger deposits termed hard clusters. Breakdown of the hard drusen results in varying degrees of softening and confluence. These soft clusters may appear in middle age and, like the preceding hard drusen, remain a focal pathology. Soft clusters commonly lead to the atrophic form of age-related macular degeneration. Another type of soft drusen is formed from membranous debris as part of a diffuse disturbance of the retinal pigment epithelium. These membranous soft drusen first appear in the seventh decade and are commonly associated with choroidal neovascularisation. |
| Author | SARKS, S. H KLIINGSWORTH, M. C SARKS, J. P |
| Author_xml | – sequence: 1 givenname: J. P surname: SARKS fullname: SARKS, J. P organization: Lidcombe hosp., dep. ophthalmology, Sydney N.S.W., Australia – sequence: 2 givenname: S. H surname: SARKS fullname: SARKS, S. H organization: Lidcombe hosp., dep. ophthalmology, Sydney N.S.W., Australia – sequence: 3 givenname: M. C surname: KLIINGSWORTH fullname: KLIINGSWORTH, M. C organization: Lidcombe hosp., dep. ophthalmology, Sydney N.S.W., Australia |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4221704$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/7525362$$D View this record in MEDLINE/PubMed |
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| Keywords | Human Pathology Macula Eye disease Retinopathy Drusen Pathogenesis Exploration Retina Maculopathy Degeneration Elderly |
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| SubjectTerms | Adult Aged Aged, 80 and over Aging - pathology Biological and medical sciences Female Fluorescein Angiography Humans Macular Degeneration - complications Macular Degeneration - pathology Male Medical sciences Microscopy, Electron Middle Aged Neovascularization, Pathologic - pathology Ophthalmology Retina - ultrastructure Retinal Detachment - etiology Retinal Drusen - etiology Retinal Drusen - pathology Retinopathies |
| Title | Evolution of soft drusen in age-related macular degeneration |
| URI | http://dx.doi.org/10.1038/eye.1994.57 https://www.ncbi.nlm.nih.gov/pubmed/7525362 https://search.proquest.com/docview/76824754 |
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