Improved Synthesis of Dbibb as a New Anti-Radiation Agent

• Published in: Chemistry of natural compounds Vol. 54; no. 3; pp. 499 - 501
• Main Authors: Yang, Hong-Peng, Zhang, Shou-Guo, Wang, Gang, Wen, Xiao-Xue, Sun, Yun-Bo, Liu, Shu-Chen, Peng, Tao, Wang, Lin
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2018; Springer Nature; Springer; Springer Nature B.V
• Subjects: Acidification; agonists; Benzoic acid; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Hydrochloric acid; Ionizing radiation; Life Sciences & Biomedicine; Medicine; methodology; Nuclear energy; Nuclear radiation; Organic Chemistry; Pharmacology & Pharmacy; Pharmacy; Physical Sciences; Plant Sciences; Radiation damage; saccharin; Science & Technology; Sodium hydroxide; Synthesis; DBIBB; new method; lysophospholipid acid receptor 2; saccharin; LPA RECEPTOR; MITIGATION; SELECTIVITY; AGONIST

An excellent candidate in the fight against damage caused by nuclear radiation is 2-[4-(1,3-dioxo-1H,3Hbenzoisoquinolin-2-yl)butylsulfamoyl]benzoic acid (DBIBB), a lipid agonist of lysophospholipid acid receptor 2. In this study, a novel method that synthesizes DBIBB was developed. In this method, s...