Improved Synthesis of Dbibb as a New Anti-Radiation Agent
An excellent candidate in the fight against damage caused by nuclear radiation is 2-[4-(1,3-dioxo-1H,3Hbenzoisoquinolin-2-yl)butylsulfamoyl]benzoic acid (DBIBB), a lipid agonist of lysophospholipid acid receptor 2. In this study, a novel method that synthesizes DBIBB was developed. In this method, s...
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| Published in | Chemistry of natural compounds Vol. 54; no. 3; pp. 499 - 501 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Springer US
01.05.2018
Springer Nature Springer Springer Nature B.V |
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| Abstract | An excellent candidate in the fight against damage caused by nuclear radiation is 2-[4-(1,3-dioxo-1H,3Hbenzoisoquinolin-2-yl)butylsulfamoyl]benzoic acid (DBIBB), a lipid agonist of lysophospholipid acid receptor 2. In this study, a novel method that synthesizes DBIBB was developed. In this method, saccharin was replaced singly by 1,4-dibromobutane, reacted with 1,8-naphthalimide, hydrolyzed by sodium hydroxide, and finally acidified by hydrochloric acid to obtain DBIBB. The new synthesis route was shorter, milder, and simpler than previously reported approaches. The method also produced higher total yield than that of existing ones. Thus, it is applicable to the large-scale synthesis of DBIBB. |
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| AbstractList | An excellent candidate in the fight against damage caused by nuclear radiation is 2-[4-(1,3-dioxo-1H,3Hbenzoisoquinolin-2-yl)butylsulfamoyl]benzoic acid (DBIBB), a lipid agonist of lysophospholipid acid receptor 2. In this study, a novel method that synthesizes DBIBB was developed. In this method, saccharin was replaced singly by 1,4-dibromobutane, reacted with 1,8-naphthalimide, hydrolyzed by sodium hydroxide, and finally acidified by hydrochloric acid to obtain DBIBB. The new synthesis route was shorter, milder, and simpler than previously reported approaches. The method also produced higher total yield than that of existing ones. Thus, it is applicable to the large-scale synthesis of DBIBB. |
| Audience | Academic |
| Author | Yang, Hong-Peng Wen, Xiao-Xue Sun, Yun-Bo Peng, Tao Liu, Shu-Chen Wang, Gang Wang, Lin Zhang, Shou-Guo |
| Author_xml | – sequence: 1 givenname: Hong-Peng surname: Yang fullname: Yang, Hong-Peng organization: Anhui Medical University, Institute of Radiation Medicine, Academy of Military Medical Sciences – sequence: 2 givenname: Shou-Guo surname: Zhang fullname: Zhang, Shou-Guo organization: Institute of Radiation Medicine, Academy of Military Medical Sciences – sequence: 3 givenname: Gang surname: Wang fullname: Wang, Gang organization: Institute of Radiation Medicine, Academy of Military Medical Sciences – sequence: 4 givenname: Xiao-Xue surname: Wen fullname: Wen, Xiao-Xue organization: Institute of Radiation Medicine, Academy of Military Medical Sciences – sequence: 5 givenname: Yun-Bo surname: Sun fullname: Sun, Yun-Bo organization: Institute of Radiation Medicine, Academy of Military Medical Sciences – sequence: 6 givenname: Shu-Chen surname: Liu fullname: Liu, Shu-Chen organization: Institute of Radiation Medicine, Academy of Military Medical Sciences – sequence: 7 givenname: Tao surname: Peng fullname: Peng, Tao email: pengtao@bmi.ac.cn organization: Institute of Radiation Medicine, Academy of Military Medical Sciences – sequence: 8 givenname: Lin surname: Wang fullname: Wang, Lin email: wanglin@bmi.ac.cn, wanglin07@sina.com organization: Anhui Medical University, Institute of Radiation Medicine, Academy of Military Medical Sciences |
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| References | FujiwaraYSardarVTokumuraABakerDMurakami-MurofushiKParrillATigyiGJ. Biol. Chem.20052803503810.1074/jbc.M504351200161158901:CAS:528:DC%2BD2MXhtVyks7vL PatilRSzaboEFellsJBaloghALimKGFujiwaraYNormanDLeeSCBalazsLThomasFPatilSKarinE-TBolerAStrobosJMcCoolSYatesCStabenowJByrneGMillerDTigyiGBiol. Chem.20152220610.1016/j.chembiol.2014.12.0091:CAS:528:DC%2BC2MXhsVarsro%3D BaloghAShimizuYLeeSCNormanDGangwarRBavariaMMoonCShuklaPRaoRRayRNarenAPBanerjeSMillerDBalazsLPelusLTigyiGCell. Signal.201527175110.1016/j.cellsig.2015.05.0152602751745149201:CAS:528:DC%2BC2MXhtVSgt7jL KissGNFellsJIGupteRLeeSCLiuJNusserNLimKGRayRMLinFTParrillALSumegiBMillerDDTigyiGMol. Pharmacol.201282116210.1124/mol.112.0796992296830435026181:CAS:528:DC%2BC38XhslCltb3M LeeYTCuiCJChowEPueNLonhienneTWangJGFraserJAGuddatLWJ. Med. Chem.20135621010.1021/jm301501k232373841:CAS:528:DC%2BC38XhvVCjurbN KnowldenSAHillmanSEChapmanTJPatilRMillerDTigyiGAm. J. Respir. Cell Mol. Biol.20165440210.1165/rcmb.2015-0124OC2624801848210341:CAS:528:DC%2BC28XhtVKlurbN KissGNLeeSCFellsJILiuJValentineWJFujiwaraYThompsonKEYatesCRSumegiBTigyiGBiochim. Biophys. Acta2013183111710.1016/j.bbalip.2012.08.0202312751234913611:CAS:528:DC%2BC38Xhs1ajtrrL KamalARamuRTekumallaVKhannaGBBarkumeMSJuvekarASZingdeSMBioorg. Med. Chem.200816721810.1016/j.bmc.2008.06.034186563701:CAS:528:DC%2BD1cXps12jt7k%3D PatilRFellsJSzaboELimKGNormanDBaloghAPatilSStrobosJMillerDTigyiGJ. Med. Chem.201457713610.1021/jm50071162510050241481591:CAS:528:DC%2BC2cXht12gurrJ DengWShuyuETsukaharaRValentineWJDurgamGGududuruVBalazsLManickamVArsuraMVanMiddlesworthLJohnsonLRParrillALMillerDDTigyiGGastroenterology2007132183410.1053/j.gastro.2007.03.0381748487834467911:CAS:528:DC%2BD2sXmsVymsL4%3D SardarVMBautistaDLFischerDJYokoyamaKNusserNViragTWangDABakerDLTigyiGParrillALBiochim. Biophys. Acta2002158230910.1016/S1388-1981(02)00185-3120698421:CAS:528:DC%2BD38XksF2htbg%3D Sardar, VM (WOS:000176523700040) 2002; 1582 Kamal, A (WOS:000258749500015) 2008; 16 Kiss, GN (WOS:000311137500015) 2012; 82 Patil, R (WOS:000349966200006) 2015; 22 Lee, YT (WOS:000313221600018) 2013; 56 Patil, R (WOS:000341121400019) 2014; 57 Knowlden, SA (WOS:000373706400012) 2016; 54 Fujiwara, Y (WOS:000232403900077) 2005; 280 Balogh, A (WOS:000358390200009) 2015; 27 Deng, W (WOS:000246456400026) 2007; 132 Kiss, GN (WOS:000311596600014) 2013; 1831 Y Fujiwara (2388_CR6) 2005; 280 GN Kiss (2388_CR1) 2013; 1831 R Patil (2388_CR11) 2014; 57 YT Lee (2388_CR9) 2013; 56 A Kamal (2388_CR10) 2008; 16 R Patil (2388_CR8) 2015; 22 SA Knowlden (2388_CR3) 2016; 54 W Deng (2388_CR2) 2007; 132 A Balogh (2388_CR4) 2015; 27 GN Kiss (2388_CR5) 2012; 82 VM Sardar (2388_CR7) 2002; 1582 |
| References_xml | – reference: KissGNFellsJIGupteRLeeSCLiuJNusserNLimKGRayRMLinFTParrillALSumegiBMillerDDTigyiGMol. Pharmacol.201282116210.1124/mol.112.0796992296830435026181:CAS:528:DC%2BC38XhslCltb3M – reference: KnowldenSAHillmanSEChapmanTJPatilRMillerDTigyiGAm. J. Respir. Cell Mol. Biol.20165440210.1165/rcmb.2015-0124OC2624801848210341:CAS:528:DC%2BC28XhtVKlurbN – reference: BaloghAShimizuYLeeSCNormanDGangwarRBavariaMMoonCShuklaPRaoRRayRNarenAPBanerjeSMillerDBalazsLPelusLTigyiGCell. Signal.201527175110.1016/j.cellsig.2015.05.0152602751745149201:CAS:528:DC%2BC2MXhtVSgt7jL – reference: SardarVMBautistaDLFischerDJYokoyamaKNusserNViragTWangDABakerDLTigyiGParrillALBiochim. Biophys. Acta2002158230910.1016/S1388-1981(02)00185-3120698421:CAS:528:DC%2BD38XksF2htbg%3D – reference: KamalARamuRTekumallaVKhannaGBBarkumeMSJuvekarASZingdeSMBioorg. Med. Chem.200816721810.1016/j.bmc.2008.06.034186563701:CAS:528:DC%2BD1cXps12jt7k%3D – reference: KissGNLeeSCFellsJILiuJValentineWJFujiwaraYThompsonKEYatesCRSumegiBTigyiGBiochim. Biophys. Acta2013183111710.1016/j.bbalip.2012.08.0202312751234913611:CAS:528:DC%2BC38Xhs1ajtrrL – reference: PatilRSzaboEFellsJBaloghALimKGFujiwaraYNormanDLeeSCBalazsLThomasFPatilSKarinE-TBolerAStrobosJMcCoolSYatesCStabenowJByrneGMillerDTigyiGBiol. Chem.20152220610.1016/j.chembiol.2014.12.0091:CAS:528:DC%2BC2MXhsVarsro%3D – reference: LeeYTCuiCJChowEPueNLonhienneTWangJGFraserJAGuddatLWJ. Med. Chem.20135621010.1021/jm301501k232373841:CAS:528:DC%2BC38XhvVCjurbN – reference: PatilRFellsJSzaboELimKGNormanDBaloghAPatilSStrobosJMillerDTigyiGJ. Med. Chem.201457713610.1021/jm50071162510050241481591:CAS:528:DC%2BC2cXht12gurrJ – reference: FujiwaraYSardarVTokumuraABakerDMurakami-MurofushiKParrillATigyiGJ. Biol. Chem.20052803503810.1074/jbc.M504351200161158901:CAS:528:DC%2BD2MXhtVyks7vL – reference: DengWShuyuETsukaharaRValentineWJDurgamGGududuruVBalazsLManickamVArsuraMVanMiddlesworthLJohnsonLRParrillALMillerDDTigyiGGastroenterology2007132183410.1053/j.gastro.2007.03.0381748487834467911:CAS:528:DC%2BD2sXmsVymsL4%3D – volume: 16 start-page: 7218 year: 2008 ident: WOS:000258749500015 article-title: Remarkable DNA binding affinity and potential anticancer activity of pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide conjugates linked through piperazine side-armed alkane spacers publication-title: BIOORGANIC & MEDICINAL CHEMISTRY doi: 10.1016/j.bmc.2008.06.034 – volume: 1582 start-page: 309 year: 2002 ident: WOS:000176523700040 article-title: Molecular basis for lysophosphatidic acid receptor antagonist selectivity publication-title: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS – volume: 56 start-page: 210 year: 2013 ident: WOS:000313221600018 article-title: Sulfonylureas Have Antifungal Activity and Are Potent Inhibitors of Candida albicans Acetohydroxyacid Synthase publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/jm301501k – volume: 54 start-page: 402 year: 2016 ident: WOS:000373706400012 article-title: Novel Inhibitory Effect of a Lysophosphatidic Acid 2 Agonist on Allergen-Driven Airway Inflammation publication-title: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY doi: 10.1165/rcmb.2015-0124OC – volume: 27 start-page: 1751 year: 2015 ident: WOS:000358390200009 article-title: The autotaxin-LPA(2) GPCR axis is modulated by gamma-irradiation and facilitates DNA damage repair publication-title: CELLULAR SIGNALLING doi: 10.1016/j.cellsig.2015.05.015 – volume: 82 start-page: 1162 year: 2012 ident: WOS:000311137500015 article-title: Virtual Screening for LPA(2)-Specific Agonists Identifies a Nonlipid Compound with Antiapoptotic Actions publication-title: MOLECULAR PHARMACOLOGY doi: 10.1124/mol.112.079699 – volume: 22 start-page: 206 year: 2015 ident: WOS:000349966200006 article-title: Combined Mitigation of the Gastrointestinal and Hematopoietic Acute Radiation Syndromes by an LPA(2) Receptor-Specific Nonlipid Agonist publication-title: CHEMISTRY & BIOLOGY doi: 10.1016/j.chembiol.2014.12.009 – volume: 57 start-page: 7136 year: 2014 ident: WOS:000341121400019 article-title: Design and Synthesis of Sulfamoyl Benzoic Acid Analogues with Subnanomolar Agonist Activity Specific to the LPA(2) Receptor publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/jm5007116 – volume: 1831 start-page: 117 year: 2013 ident: WOS:000311596600014 article-title: Mitigation of radiation injury by selective stimulation of the LPA(2) receptor publication-title: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS doi: 10.1016/j.bbalip.2012.08.020 – volume: 132 start-page: 1834 year: 2007 ident: WOS:000246456400026 article-title: The lysophosphatidic acid type 2 receptor is required for protection publication-title: GASTROENTEROLOGY doi: 10.1053/j.gastro.2007.03.038 – volume: 280 start-page: 35038 year: 2005 ident: WOS:000232403900077 article-title: Identification of residues responsible for ligand recognition and regioisomeric selectivity of lysophosphatidic acid receptors expressed in mammalian cells publication-title: JOURNAL OF BIOLOGICAL CHEMISTRY doi: 10.1074/jbc.M504351200 – volume: 57 start-page: 7136 year: 2014 ident: 2388_CR11 publication-title: J. Med. Chem. doi: 10.1021/jm5007116 – volume: 280 start-page: 35038 year: 2005 ident: 2388_CR6 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M504351200 – volume: 27 start-page: 1751 year: 2015 ident: 2388_CR4 publication-title: Cell. Signal. doi: 10.1016/j.cellsig.2015.05.015 – volume: 1831 start-page: 117 year: 2013 ident: 2388_CR1 publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbalip.2012.08.020 – volume: 1582 start-page: 309 year: 2002 ident: 2388_CR7 publication-title: Biochim. Biophys. Acta doi: 10.1016/S1388-1981(02)00185-3 – volume: 132 start-page: 1834 year: 2007 ident: 2388_CR2 publication-title: Gastroenterology doi: 10.1053/j.gastro.2007.03.038 – volume: 16 start-page: 7218 year: 2008 ident: 2388_CR10 publication-title: Bioorg. Med. Chem. doi: 10.1016/j.bmc.2008.06.034 – volume: 54 start-page: 402 year: 2016 ident: 2388_CR3 publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/rcmb.2015-0124OC – volume: 56 start-page: 210 year: 2013 ident: 2388_CR9 publication-title: J. Med. Chem. doi: 10.1021/jm301501k – volume: 82 start-page: 1162 year: 2012 ident: 2388_CR5 publication-title: Mol. Pharmacol. doi: 10.1124/mol.112.079699 – volume: 22 start-page: 206 year: 2015 ident: 2388_CR8 publication-title: Biol. Chem. doi: 10.1016/j.chembiol.2014.12.009 |
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| Snippet | An excellent candidate in the fight against damage caused by nuclear radiation is 2-[4-(1,3-dioxo-1H,3Hbenzoisoquinolin-2-yl)butylsulfamoyl]benzoic acid... |
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| SubjectTerms | Acidification agonists Benzoic acid Chemistry Chemistry, Medicinal Chemistry, Organic Hydrochloric acid Ionizing radiation Life Sciences & Biomedicine Medicine methodology Nuclear energy Nuclear radiation Organic Chemistry Pharmacology & Pharmacy Pharmacy Physical Sciences Plant Sciences Radiation damage saccharin Science & Technology Sodium hydroxide Synthesis |
| Title | Improved Synthesis of Dbibb as a New Anti-Radiation Agent |
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