Gene transfer of IFN-gamma into established brain tumors represses growth by antiangiogenesis

• Published in: The Journal of immunology (1950) Vol. 164; no. 1; pp. 217 - 222
• Main Authors: Fathallah-Shaykh, H M, Zhao, L J, Kafrouni, A I, Smith, G M, Forman, J
• Format: Journal Article
• Language: English
• Published: United States 01.01.2000
• Subjects: Adenoviridae - genetics; Adenoviridae - immunology; Angiogenesis Inhibitors - administration & dosage; Angiogenesis Inhibitors - genetics; Angiogenesis Inhibitors - immunology; Angiogenesis Inhibitors - therapeutic use; Animals; Brain Neoplasms - blood supply; Brain Neoplasms - genetics; Brain Neoplasms - immunology; Brain Neoplasms - therapy; Carcinoma, Lewis Lung; g-Interferon; Gene Transfer Techniques; Genetic Vectors - administration & dosage; Genetic Vectors - immunology; Genetic Vectors - therapeutic use; Humans; Immunologic Memory; Injections, Intraventricular; Interferon-gamma - administration & dosage; Interferon-gamma - genetics; Interferon-gamma - therapeutic use; Mice; Mice, Inbred C57BL; Mice, SCID; Neoplasm Transplantation

The experiments in this paper were designed to examine the therapeutic effects of adenoviral-mediated gene transfer of IFN-gamma into a mouse model of an established metastatic brain tumor. Temperature-sensitive replication-defective adenovirus was generated for gene transfer of IFN-gamma (AdIFN) an...