Variability in sensitivity to arsenite does not correlate with arsenic accumulation rate in normal human lymphoblasts

• Published in: Molecular and cellular biochemistry Vol. 255; no. 1-2; pp. 79 - 85
• Main Authors: Li, Ping, Uddin, Ahmed N., Liu, Zijuan, Mukhopadhyay, Rita, Komissarova, Elena V., Rosen, Barry P., Rossman, Toby G.
• Format: Journal Article
• Language: English
• Published: Netherlands Springer Nature B.V 01.01.2004
• Subjects: Accumulation; Adolescent; Adult; Arsenic; Arsenites - metabolism; Arsenites - pharmacokinetics; Arsenites - toxicity; Cell Line, Transformed; Child; Chromosome aberrations; Chromosome Aberrations - chemically induced; Contaminants; Drug Resistance - genetics; Genes; Genetic Variation; Humans; Lymphocytes; Lymphocytes - drug effects; Lymphocytes - metabolism; Middle Aged; Sister Chromatid Exchange - physiology; Teratogens - metabolism; Teratogens - pharmacokinetics; Teratogens - toxicity; Water pollution; Yeasts
• ISSN: 0300-8177; 1573-4919
• DOI: 10.1023/B:MCBI.0000007263.27349.ae

Arsenic is a common environmental contaminant of our air, water and food, but not every individual who drinks arsenic-contaminated water shows clinical signs of toxicity. Large inter-individual variations are also found in arsenite-induced aneuploidy, chromosome aberrations and sister chromatid exch...