m6A methylation regulators and ncRNAs in osteosarcoma: Potential therapeutic strategies

• Published in: Progress in biophysics and molecular biology Vol. 194; pp. 34 - 42
• Main Authors: Shi, Ce, Chen, Lei, Huang, Kui, Yang, Guanghui, Shi, Tingting, Li, Jinshuang, Zheng, Hongbing
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2024
• Subjects: Adenosine - analogs & derivatives; Adenosine - metabolism; Animals; Bone Neoplasms - drug therapy; Bone Neoplasms - genetics; Bone Neoplasms - metabolism; Bone Neoplasms - pathology; Bone Neoplasms - therapy; Gene Expression Regulation, Neoplastic; Humans; m6A modification; Methylation; ncRNA; Osteosarcoma; Osteosarcoma - drug therapy; Osteosarcoma - genetics; Osteosarcoma - metabolism; Osteosarcoma - pathology; RNA, Untranslated - genetics; RNA, Untranslated - metabolism; Therapeutic target; m6A modification; ncRNA; Osteosarcoma; Therapeutic target
• ISSN: 0079-6107; 1873-1732; 1873-1732
• DOI: 10.1016/j.pbiomolbio.2024.10.003

Osteosarcoma (OS) represents the primary form of bone cancer observed in paediatric and adolescent populations. Nearly 10%–15% of patients have metastases at diagnosis, and the 5-year survival rate was less than 20%. Although numerous investigators have offered significant efforts, the survival rates for patients with OS have remained almost unchanged over the past three decades. The most pervasive and abundant modification of internal transcripts in eukaryotic messenger RNAs (mRNAs) is N6-methyladenosine (m6A), and it is regulated by m6A methylation regulators. A number of recent studies have demonstrated that m6A modifications can regulate the biological activities of tumour cells and are intimately linked with cancer development, prognosis, drug resistance, and therapy. N6-methyladenosine modification of Non-coding RNA (ncRNA) has likewise shown a broad potential in gene regulation and tumor biology. Epigenetic changes induced by mRNAs and ncRNAs methylation are important for a better understanding of OS development and targeted drug development. Therefore, this paper summarises the biological functions of m6A-modified regulators in osteosarcoma and the role of mutual regulation between m6A and ncRNAs in osteosarcoma. Furthermore, the potential clinical applications of m6A modifications in OS are presented for consideration. It provides new directions for the future research and clinical treatment strategies of osteosarcoma. •m6A regulators' biological functions in Osteosarcoma.•Effect of m6A regulators on radiotherapy resistance in osteosarcoma.•NcRNA in osteosarcoma.•Interplay between m6A and ncRNAs in osteosarcoma.•m6A and miRNA, circRNA, lncRNA.