The first resolution revolution in protein structure analysis: X-ray diffraction of polypeptide conformations and globular protein folds in 1950s and 1960s

• Published in: Progress in biophysics and molecular biology Vol. 167; pp. 32 - 40
• Main Author: Blundell, Tom L.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2021
• Subjects: Crystallography, X-Ray; Hemoglobins; Peptides; Polypeptides; Protein Conformation; Proteins; Retrospective Studies; X-Ray Diffraction; Proteins; X-ray diffraction; Polypeptides

Although determination of structures of biological molecules became a real possibility after the first X-ray analyses of crystals by the William Henry Bragg and his son Lawrence in 1913, the crystal structure determination of globular proteins became a possibility only in 1934 with the demonstration...