Fluconazole for the Treatment of Cutaneous Leishmaniasis
To the Editor: Alrajhi et al. (March 21 issue) 1 report on the efficacy of systemic fluconazole for Old World cutaneous leishmaniasis caused by Leishmania major . Although this therapy was more efficacious than placebo, the rationale for the study is questionable. Because of potential side effects a...
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| Published in | The New England journal of medicine Vol. 347; no. 5; pp. 370 - 371 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Massachusetts Medical Society
01.08.2002
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| Subjects | |
| Online Access | Get full text |
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| Abstract | To the Editor:
Alrajhi et al. (March 21 issue)
1
report on the efficacy of systemic fluconazole for Old World cutaneous leishmaniasis caused by
Leishmania major
. Although this therapy was more efficacious than placebo, the rationale for the study is questionable. Because of potential side effects and high costs, it is unlikely that any systemic therapy will ever become the first-choice therapy for uncomplicated Old World cutaneous leishmaniasis, which is a self-limited skin disease that is usually amenable to topical treatments. Moreover, the cost of six weeks of treatment with fluconazole at a dose of 200 mg per day is . . . |
|---|---|
| AbstractList | To the Editor:
Alrajhi et al. (March 21 issue)
1
report on the efficacy of systemic fluconazole for Old World cutaneous leishmaniasis caused by
Leishmania major
. Although this therapy was more efficacious than placebo, the rationale for the study is questionable. Because of potential side effects and high costs, it is unlikely that any systemic therapy will ever become the first-choice therapy for uncomplicated Old World cutaneous leishmaniasis, which is a self-limited skin disease that is usually amenable to topical treatments. Moreover, the cost of six weeks of treatment with fluconazole at a dose of 200 mg per day is . . . |
| Author | Vardy, Daniel Klaus, Sidney Zvulunov, Alex |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12151480$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1517_13543784_12_2_197 crossref_primary_10_1016_j_ijantimicag_2007_01_013 crossref_primary_10_1016_S0151_9638_07_91833_5 crossref_primary_10_1007_s11908_008_0065_0 crossref_primary_10_1080_1061186X_2018_1536982 |
| Cites_doi | 10.4269/ajtmh.1995.53.162 10.1016/0035-9203(90)90146-6 10.1111/1523-1747.ep12696697 10.1016/0190-9622(92)70175-F 10.1056/NEJMoa011882 10.1001/archderm.135.7.856 10.4269/ajtmh.1995.53.648 10.1046/j.1365-4362.1997.00022.x |
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| Copyright | Copyright © 2002 Massachusetts Medical Society. All rights reserved. |
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| References | 11907288 - N Engl J Med. 2002 Mar 21;346(12):891-5 r006 r007 r002 r003 L1 r004 r005 r001 Ben Salah A (r009) 1995; 53 Asilian A (r008) 1995; 53 |
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| Snippet | To the Editor:
Alrajhi et al. (March 21 issue)
1
report on the efficacy of systemic fluconazole for Old World cutaneous leishmaniasis caused by
Leishmania... |
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| SubjectTerms | Administration, Topical Animals Antifungal Agents - economics Antifungal Agents - therapeutic use Antiprotozoal Agents - administration & dosage Fluconazole - economics Fluconazole - therapeutic use Humans Leishmania major Leishmaniasis, Cutaneous - drug therapy Paromomycin - administration & dosage |
| Title | Fluconazole for the Treatment of Cutaneous Leishmaniasis |
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