Toxoplasmosis accelerates acquisition of epilepsy in rats undergoing chemical kindling
[Display omitted] •Toxoplasma gondii has high tendency to excitable cells including neurons.•Male rats were infected by i.p. injection of Toxoplasma gondii cysts.•Cerebral toxoplasmosis confirmed by histologic examination.•Toxoplasmosis accelerates the rate of PTZ kindling in the infected rats.•Toxo...
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Published in | Epilepsy research Vol. 135; pp. 137 - 142 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
01.09.2017
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Abstract | [Display omitted]
•Toxoplasma gondii has high tendency to excitable cells including neurons.•Male rats were infected by i.p. injection of Toxoplasma gondii cysts.•Cerebral toxoplasmosis confirmed by histologic examination.•Toxoplasmosis accelerates the rate of PTZ kindling in the infected rats.•Toxoplasmosis might be a risk factor for acquisition of epilepsy.
Epilepsy is one of the most common neurologic disorders worldwide with no distinguishable cause in 60% of patients. One-third of the world population has been infected with Toxoplasma gondii. This intracellular parasite has high tropism for excitable cells including neurons. We assessed impact of acute and chronic T. gondii infection on epileptogenesis in pentylenetetrazole (PTZ) kindling model in male rats. T. gondii cysts were administered to rats by intraperitoneal (i.p.) injection. The presence of T. gondii cysts in the brain of rats was verified by hematoxylin-eosin staining. One and eight weeks after cysts injection, as acute and chronic phases of infection, PTZ (30mg/kg, i.p.) was injected to the rats every other day until manifestation of generalized seizures. Histologic findings confirmed cerebral toxoplasmosis in rats. The rats with acute or chronic Toxoplasma infection became kindled by lower number of PTZ injections (14.8±1 and 13.6±1 injections, respectively) compared to corresponding uninfected rats (18.7±1 and 16.9±1 injections, p<0.05). Toxoplasma infection increased the rate of kindling in rats. The chronically-infected rats achieved focal and also generalized seizures earlier than the rats with acute infection. Toxoplasmosis might be considered as a risk factor for acquisition of epilepsy. |
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AbstractList | Epilepsy is one of the most common neurologic disorders worldwide with no distinguishable cause in 60% of patients. One-third of the world population has been infected with Toxoplasma gondii. This intracellular parasite has high tropism for excitable cells including neurons. We assessed impact of acute and chronic T. gondii infection on epileptogenesis in pentylenetetrazole (PTZ) kindling model in male rats. T. gondii cysts were administered to rats by intraperitoneal (i.p.) injection. The presence of T. gondii cysts in the brain of rats was verified by hematoxylin-eosin staining. One and eight weeks after cysts injection, as acute and chronic phases of infection, PTZ (30mg/kg, i.p.) was injected to the rats every other day until manifestation of generalized seizures. Histologic findings confirmed cerebral toxoplasmosis in rats. The rats with acute or chronic Toxoplasma infection became kindled by lower number of PTZ injections (14.8±1 and 13.6±1 injections, respectively) compared to corresponding uninfected rats (18.7±1 and 16.9±1 injections, p<0.05). Toxoplasma infection increased the rate of kindling in rats. The chronically-infected rats achieved focal and also generalized seizures earlier than the rats with acute infection. Toxoplasmosis might be considered as a risk factor for acquisition of epilepsy. Epilepsy is one of the most common neurologic disorders worldwide with no distinguishable cause in 60% of patients. One-third of the world population has been infected with Toxoplasma gondii. This intracellular parasite has high tropism for excitable cells including neurons. We assessed impact of acute and chronic T. gondii infection on epileptogenesis in pentylenetetrazole (PTZ) kindling model in male rats. T. gondii cysts were administered to rats by intraperitoneal (i.p.) injection. The presence of T. gondii cysts in the brain of rats was verified by hematoxylin-eosin staining. One and eight weeks after cysts injection, as acute and chronic phases of infection, PTZ (30mg/kg, i.p.) was injected to the rats every other day until manifestation of generalized seizures. Histologic findings confirmed cerebral toxoplasmosis in rats. The rats with acute or chronic Toxoplasma infection became kindled by lower number of PTZ injections (14.8±1 and 13.6±1 injections, respectively) compared to corresponding uninfected rats (18.7±1 and 16.9±1 injections, p<0.05). Toxoplasma infection increased the rate of kindling in rats. The chronically-infected rats achieved focal and also generalized seizures earlier than the rats with acute infection. Toxoplasmosis might be considered as a risk factor for acquisition of epilepsy. [Display omitted] •Toxoplasma gondii has high tendency to excitable cells including neurons.•Male rats were infected by i.p. injection of Toxoplasma gondii cysts.•Cerebral toxoplasmosis confirmed by histologic examination.•Toxoplasmosis accelerates the rate of PTZ kindling in the infected rats.•Toxoplasmosis might be a risk factor for acquisition of epilepsy. Epilepsy is one of the most common neurologic disorders worldwide with no distinguishable cause in 60% of patients. One-third of the world population has been infected with Toxoplasma gondii. This intracellular parasite has high tropism for excitable cells including neurons. We assessed impact of acute and chronic T. gondii infection on epileptogenesis in pentylenetetrazole (PTZ) kindling model in male rats. T. gondii cysts were administered to rats by intraperitoneal (i.p.) injection. The presence of T. gondii cysts in the brain of rats was verified by hematoxylin-eosin staining. One and eight weeks after cysts injection, as acute and chronic phases of infection, PTZ (30mg/kg, i.p.) was injected to the rats every other day until manifestation of generalized seizures. Histologic findings confirmed cerebral toxoplasmosis in rats. The rats with acute or chronic Toxoplasma infection became kindled by lower number of PTZ injections (14.8±1 and 13.6±1 injections, respectively) compared to corresponding uninfected rats (18.7±1 and 16.9±1 injections, p<0.05). Toxoplasma infection increased the rate of kindling in rats. The chronically-infected rats achieved focal and also generalized seizures earlier than the rats with acute infection. Toxoplasmosis might be considered as a risk factor for acquisition of epilepsy. |
Author | Sayyah, Mohammad Golkar, Majid Gharagozli, Kourosh Choopani, Samira Asgari, Tara Babaie, Jalal |
Author_xml | – sequence: 1 givenname: Jalal surname: Babaie fullname: Babaie, Jalal organization: Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran – sequence: 2 givenname: Mohammad surname: Sayyah fullname: Sayyah, Mohammad email: sayyahm2@pasteur.ac.ir organization: Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran – sequence: 3 givenname: Samira surname: Choopani fullname: Choopani, Samira organization: Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran – sequence: 4 givenname: Tara surname: Asgari fullname: Asgari, Tara organization: Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran – sequence: 5 givenname: Majid surname: Golkar fullname: Golkar, Majid organization: Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran – sequence: 6 givenname: Kourosh surname: Gharagozli fullname: Gharagozli, Kourosh organization: Department of Neurology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28688333$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1039_C7RA11491E crossref_primary_10_1111_jsap_13735 crossref_primary_10_1186_s12974_020_01885_3 crossref_primary_10_1038_s41598_023_35971_2 crossref_primary_10_1002_pmic_201800271 crossref_primary_10_1016_j_micpath_2021_105302 crossref_primary_10_1016_j_micpath_2020_104204 crossref_primary_10_4274_ArchEpilepsy_2023_23102 crossref_primary_10_1093_trstmh_trz025 crossref_primary_10_1155_2021_6634807 |
Cites_doi | 10.1016/S2222-1808(14)60718-0 10.1046/j.1528-1157.2001.25500.x 10.1016/j.exppara.2015.06.009 10.1016/S0091-3057(96)00418-2 10.1016/S1474-4422(13)70003-6 10.1016/j.exppara.2012.10.005 10.1371/journal.ppat.1003051 10.1128/mBio.01428-15 10.1016/S1059-1311(02)00256-X 10.1242/jeb.074716 10.1016/S0304-4017(97)00227-6 10.1242/jeb.074153 10.14411/fp.2010.013 10.1016/j.seizure.2006.12.008 10.1073/pnas.0608310104 10.1016/j.micpath.2015.07.013 10.1002/jnr.24036 10.1111/epi.12605 10.1016/j.seizure.2007.05.010 10.1186/s13071-015-1103-z 10.1016/j.nbd.2016.03.005 10.1016/j.prp.2014.04.025 10.1371/journal.pone.0028925 10.1016/0013-4694(72)90177-0 10.1371/journal.pntd.0003525 |
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Keywords | Epileptogenesis Pentylenetetrazole Toxoplasma gondii Rat Kindling |
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References | Dubey, Frenkel (bib0045) 1998; 77 Zhou, Zhu, Xu, Zhang, Mao, Yang, Fan, Xu, Zhao, Tao (bib0160) 2015; 33 Berenreiterova, Flegr, Kubena, Nemec (bib0025) 2011; 6 El-Tantawy, El-Nahas, Salem, Salem, Hasaneen (bib0050) 2013; 1 Fekadu, Shibre, Cleare (bib0055) 2010; 57 McConkey, Martin, Bristow, Webster (bib0090) 2013; 216 Babaie, Sayyah, Fard-Esfahani, Golkar, Gharagozli (bib0010) 2017 Fuks, Arrighi, Weidner, Kumar Mendu, Jin, Wallin, Rethi, Birnir, Barragan (bib0060) 2012; 8 Zhou, Fan, Zhang, Huang, Xu, Tao, Gao (bib0155) 2013; 31 Ngoungou, Bhalla, Nzoghe, Darde, Preux (bib0095) 2015; 9 Ghorbani, Samii (bib0070) 1973; 76 Webster, Kaushik, Bristow, McConkey (bib0140) 2013; 216 Palmer (bib0105) 2007; 16 Saraei, Ghaderi, Mosavi, Shahnazi, Keshavarz, Shojaee (bib0115) 2014; 4 Grecksch, Becker, Rauca (bib0075) 1997; 56 Zibaei, Zamani, Esfahani, Anbari, Nazer (bib0165) 2011; 16 Brooks, Carrillo, Su, Lindsay, Fox, Blader (bib0035) 2015; 6 Yazar, Arman, Yalcin, Demirtas, Yaman, Sahin (bib0150) 2003; 12 Bottari, Baldissera, Tonin, Rech, Nishihira, Thome, Camillo, Vogel, Duarte, Schetinger, Morsch, Tochetto, Fighera, Da Silva (bib0030) 2015; 87 Ngugi, Bottomley, Kleinschmidt, Wagner, Kakooza-Mwesige, Ae-Ngibise, Owusu-Agyei, Masanja, Kamuyu, Odhiambo, Chengo, Sander, Newton (bib0100) 2013; 12 Racine (bib0110) 1972; 32 Weiss, Kim (bib0145) 2014 Babaie, Sayyah, Gharagozli, Mostafavi, Golkar (bib0015) 2017; 16 Dincel, Atmaca (bib0040) 2015; 156 Gatkowska, Wieczorek, Dziadek, Dzitko, Dlugonska (bib0065) 2013; 133 Bell, Neligan, Sander (bib0020) 2014; 55 Kannan, Crawford, Yang, Gressitt, Ihenatu, Krasnova, Cadet, Yolken, Severance, Pletnikov (bib0080) 2016; 91 Akyol, Bicerol, Ertug, Ertabaklar, Kiylioglu (bib0005) 2007; 16 Martin, Fanaroff, Walsh (bib0085) 2011 Stommel, Seguin, Thadani, Schwartzman, Gilbert, Ryan, Tosteson, Kasper (bib0120) 2001; 42 Tonin, Da Silva, Thome, Sangoi, Oliveira, Flores, Schetinger, Fighera, Moresco, Camillo, Vogel, Lopes (bib0125) 2014; 210 Vyas, Kim, Giacomini, Boothroyd, Sapolsky (bib0130) 2007; 104 Wan, Gong, Wang, An, Zheng, Jiang, Tang, Zhang, Chen, Yu, Shen, Du (bib0135) 2015; 8 Yazar (10.1016/j.eplepsyres.2017.06.012_bib0150) 2003; 12 Palmer (10.1016/j.eplepsyres.2017.06.012_bib0105) 2007; 16 Zibaei (10.1016/j.eplepsyres.2017.06.012_bib0165) 2011; 16 Bottari (10.1016/j.eplepsyres.2017.06.012_bib0030) 2015; 87 Grecksch (10.1016/j.eplepsyres.2017.06.012_bib0075) 1997; 56 Saraei (10.1016/j.eplepsyres.2017.06.012_bib0115) 2014; 4 Berenreiterova (10.1016/j.eplepsyres.2017.06.012_bib0025) 2011; 6 Fuks (10.1016/j.eplepsyres.2017.06.012_bib0060) 2012; 8 Brooks (10.1016/j.eplepsyres.2017.06.012_bib0035) 2015; 6 Babaie (10.1016/j.eplepsyres.2017.06.012_bib0010) 2017 El-Tantawy (10.1016/j.eplepsyres.2017.06.012_bib0050) 2013; 1 Webster (10.1016/j.eplepsyres.2017.06.012_bib0140) 2013; 216 Akyol (10.1016/j.eplepsyres.2017.06.012_bib0005) 2007; 16 Wan (10.1016/j.eplepsyres.2017.06.012_bib0135) 2015; 8 Ngugi (10.1016/j.eplepsyres.2017.06.012_bib0100) 2013; 12 Vyas (10.1016/j.eplepsyres.2017.06.012_bib0130) 2007; 104 Martin (10.1016/j.eplepsyres.2017.06.012_bib0085) 2011 Ngoungou (10.1016/j.eplepsyres.2017.06.012_bib0095) 2015; 9 Kannan (10.1016/j.eplepsyres.2017.06.012_bib0080) 2016; 91 Stommel (10.1016/j.eplepsyres.2017.06.012_bib0120) 2001; 42 Weiss (10.1016/j.eplepsyres.2017.06.012_bib0145) 2014 Bell (10.1016/j.eplepsyres.2017.06.012_bib0020) 2014; 55 Dubey (10.1016/j.eplepsyres.2017.06.012_bib0045) 1998; 77 Tonin (10.1016/j.eplepsyres.2017.06.012_bib0125) 2014; 210 Zhou (10.1016/j.eplepsyres.2017.06.012_bib0160) 2015; 33 McConkey (10.1016/j.eplepsyres.2017.06.012_bib0090) 2013; 216 Ghorbani (10.1016/j.eplepsyres.2017.06.012_bib0070) 1973; 76 Zhou (10.1016/j.eplepsyres.2017.06.012_bib0155) 2013; 31 Babaie (10.1016/j.eplepsyres.2017.06.012_bib0015) 2017; 16 Fekadu (10.1016/j.eplepsyres.2017.06.012_bib0055) 2010; 57 Racine (10.1016/j.eplepsyres.2017.06.012_bib0110) 1972; 32 Dincel (10.1016/j.eplepsyres.2017.06.012_bib0040) 2015; 156 Gatkowska (10.1016/j.eplepsyres.2017.06.012_bib0065) 2013; 133 |
References_xml | – volume: 210 start-page: 526 year: 2014 end-page: 532 ident: bib0125 article-title: Influence of toxoplasmosis on acetylcholinesterase activity, nitric oxide levels and cellular lesion on the brain of mice publication-title: Pathol. Res. Pract. contributor: fullname: Lopes – volume: 33 start-page: 29 year: 2015 end-page: 32 ident: bib0160 article-title: Effect of toxoplasma gondii infection in female mice on dopamine level in the brain of the male offspring publication-title: Zhongguo. Ji. Sheng. Chong. Xue. Yu. Ji. Sheng. Chong. Bing. Za. Zhi. contributor: fullname: Tao – volume: 12 start-page: 253 year: 2013 end-page: 263 ident: bib0100 article-title: Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies publication-title: Lancet Neurol. contributor: fullname: Newton – volume: 42 start-page: 436 year: 2001 end-page: 438 ident: bib0120 article-title: Cryptogenic epilepsy: an infectious etiology? publication-title: Epilepsia contributor: fullname: Kasper – volume: 6 start-page: e01428 year: 2015 end-page: 01415 ident: bib0035 article-title: Toxoplasma gondii infections alter GABAergic synapses and signaling in the central nervous system publication-title: MBio contributor: fullname: Blader – volume: 31 start-page: 454 year: 2013 end-page: 457 ident: bib0155 article-title: Proteomic study of the hippocampus tissue from rats with chronic Toxoplasma gondii infection publication-title: Zhongguo. Ji. Sheng. Chong. Xue. Yu. Ji. Sheng. Chong. Bing. Za. Zhi. contributor: fullname: Gao – volume: 16 start-page: 657 year: 2007 end-page: 663 ident: bib0105 article-title: Meta-analysis of three case controlled studies and an ecological study into the link between cryptogenic epilepsy and chronic toxoplasmosis infection publication-title: Seizure contributor: fullname: Palmer – volume: 216 start-page: 99 year: 2013 end-page: 112 ident: bib0140 article-title: Toxoplasma gondii infection, from predation to schizophrenia: can animal behaviour help us understand human behaviour? publication-title: J. Exp. Biol. contributor: fullname: McConkey – volume: 87 start-page: 40 year: 2015 end-page: 44 ident: bib0030 article-title: Effects of sulfamethoxazole-trimethoprim associated to resveratrol on its free form and complexed with 2-hydroxypropyl-beta-cyclodextrin on cytokines levels of mice infected by Toxoplasma gondii publication-title: Microb. Pathog. contributor: fullname: Da Silva – volume: 9 start-page: e0003525 year: 2015 ident: bib0095 article-title: Toxoplasmosis and epilepsy–systematic review and meta analysis publication-title: PLoS Negl. Trop Dis. contributor: fullname: Preux – volume: 16 start-page: 299 year: 2011 end-page: 302 ident: bib0165 article-title: Toxoplasma infection and epilepsy: a case-control study in Iran publication-title: Neurol. Asia contributor: fullname: Nazer – year: 2011 ident: bib0085 article-title: Fanaroff and Martin's Neonatal-perinatal Medicine: Diseases of the Fetus and Infant contributor: fullname: Walsh – volume: 1 start-page: 92 year: 2013 end-page: 95 ident: bib0050 article-title: Seroprevalence of Toxoplasma and gondii Toxocara spp. in children with cryptogenic epilepsy publication-title: Am. J. Infect. Dis. Microb contributor: fullname: Hasaneen – year: 2017 ident: bib0010 article-title: Contribution of dopamine neurotransmission in proconvulsant effect of Toxoplasma gondii infection in male mice publication-title: J. Neurosci. Res. contributor: fullname: Gharagozli – volume: 133 start-page: 1 year: 2013 end-page: 7 ident: bib0065 article-title: Sex-dependent neurotransmitter level changes in brains of Toxoplasma gondii infected mice publication-title: Exp. Parasitol. contributor: fullname: Dlugonska – volume: 16 start-page: 256 year: 2017 end-page: 264 ident: bib0015 article-title: Seroepidemiological study of Toxoplasma gondii infection in a population of Iranian epileptic patients publication-title: EXCLI J. contributor: fullname: Golkar – volume: 104 start-page: 6442 year: 2007 end-page: 6447 ident: bib0130 article-title: Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Sapolsky – volume: 8 start-page: 554 year: 2015 ident: bib0135 article-title: T. gondii rhoptry protein ROP18 induces apoptosis of neural cells via endoplasmic reticulum stress pathway publication-title: Parasit. Vectors contributor: fullname: Du – volume: 32 start-page: 281 year: 1972 end-page: 294 ident: bib0110 article-title: Modification of seizure activity by electrical stimulation II. Motor seizure publication-title: Electroencephalogr. Clin. Neurophysiol. contributor: fullname: Racine – volume: 77 start-page: 1 year: 1998 end-page: 32 ident: bib0045 article-title: Toxoplasmosis of rats: a review, with considerations of their value as an animal model and their possible role in epidemiology publication-title: Vet. Parasitol. contributor: fullname: Frenkel – volume: 16 start-page: 233 year: 2007 end-page: 237 ident: bib0005 article-title: Epilepsy and seropositivity rates of Toxocara canis and Toxoplasma gondii publication-title: Seizure contributor: fullname: Kiylioglu – start-page: 129 year: 2014 end-page: 131 ident: bib0145 article-title: Toxoplasma gondii: the model apicomplexan − perspectives and methods contributor: fullname: Kim – volume: 56 start-page: 595 year: 1997 end-page: 601 ident: bib0075 article-title: Effect of age on pentylenetetrazol-kindling and kindling-induced impairments of learning performance publication-title: Pharmacol. Biochem. Behav. contributor: fullname: Rauca – volume: 156 start-page: 104 year: 2015 end-page: 112 ident: bib0040 article-title: Nitric oxide production increases during Toxoplasma gondii encephalitis in mice publication-title: Exp. Parasitol. contributor: fullname: Atmaca – volume: 57 start-page: 105 year: 2010 end-page: 113 ident: bib0055 article-title: Toxoplasmosis as a cause for behaviour disorders?overview of evidence and mechanisms publication-title: Folia Parasitol. (Praha) contributor: fullname: Cleare – volume: 12 start-page: 107 year: 2003 end-page: 109 ident: bib0150 article-title: Investigation of probable relationship between Toxoplasma gondii and cryptogenic epilepsy publication-title: Seizure contributor: fullname: Sahin – volume: 76 start-page: 158 year: 1973 end-page: 160 ident: bib0070 article-title: Toxoplasmic lymphadenitis in Iran publication-title: J. Trop. Med. Hyg. contributor: fullname: Samii – volume: 216 start-page: 113 year: 2013 end-page: 119 ident: bib0090 article-title: Toxoplasma gondii infection and behaviour − location, location, location? publication-title: J. Exp. Biol. contributor: fullname: Webster – volume: 4 start-page: S739 year: 2014 end-page: S742 ident: bib0115 article-title: Brain cystogenesis capacity of Toxoplasma gondii avirulent Tehran strain in mice publication-title: Asian. Pac. J. Trop. Dis. contributor: fullname: Shojaee – volume: 55 start-page: 958 year: 2014 end-page: 962 ident: bib0020 article-title: An unknown quantity?the worldwide prevalence of epilepsy publication-title: Epilepsia contributor: fullname: Sander – volume: 6 start-page: e28925 year: 2011 ident: bib0025 article-title: The distribution of Toxoplasma gondii cysts in the brain of a mouse with latent toxoplasmosis: implications for the behavioral manipulation hypothesis publication-title: PLoS One contributor: fullname: Nemec – volume: 8 start-page: e1003051 year: 2012 ident: bib0060 article-title: GABAergic signaling is linked to a hypermigratory phenotype in dendritic cells infected by Toxoplasma gondii publication-title: PLoS Pathog. contributor: fullname: Barragan – volume: 91 start-page: 307 year: 2016 end-page: 314 ident: bib0080 article-title: Anti-NMDA receptor autoantibodies and associated neurobehavioral pathology in mice are dependent on age of first exposure to Toxoplasma gondii publication-title: Neurobiol. Dis. contributor: fullname: Pletnikov – volume: 16 start-page: 299 year: 2011 ident: 10.1016/j.eplepsyres.2017.06.012_bib0165 article-title: Toxoplasma infection and epilepsy: a case-control study in Iran publication-title: Neurol. Asia contributor: fullname: Zibaei – year: 2011 ident: 10.1016/j.eplepsyres.2017.06.012_bib0085 contributor: fullname: Martin – volume: 4 start-page: S739 issue: Suppl 2 year: 2014 ident: 10.1016/j.eplepsyres.2017.06.012_bib0115 article-title: Brain cystogenesis capacity of Toxoplasma gondii avirulent Tehran strain in mice publication-title: Asian. Pac. J. Trop. Dis. doi: 10.1016/S2222-1808(14)60718-0 contributor: fullname: Saraei – volume: 1 start-page: 92 year: 2013 ident: 10.1016/j.eplepsyres.2017.06.012_bib0050 article-title: Seroprevalence of Toxoplasma and gondii Toxocara spp. in children with cryptogenic epilepsy publication-title: Am. J. Infect. Dis. Microb contributor: fullname: El-Tantawy – volume: 42 start-page: 436 year: 2001 ident: 10.1016/j.eplepsyres.2017.06.012_bib0120 article-title: Cryptogenic epilepsy: an infectious etiology? publication-title: Epilepsia doi: 10.1046/j.1528-1157.2001.25500.x contributor: fullname: Stommel – volume: 156 start-page: 104 year: 2015 ident: 10.1016/j.eplepsyres.2017.06.012_bib0040 article-title: Nitric oxide production increases during Toxoplasma gondii encephalitis in mice publication-title: Exp. Parasitol. doi: 10.1016/j.exppara.2015.06.009 contributor: fullname: Dincel – volume: 56 start-page: 595 year: 1997 ident: 10.1016/j.eplepsyres.2017.06.012_bib0075 article-title: Effect of age on pentylenetetrazol-kindling and kindling-induced impairments of learning performance publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/S0091-3057(96)00418-2 contributor: fullname: Grecksch – volume: 12 start-page: 253 year: 2013 ident: 10.1016/j.eplepsyres.2017.06.012_bib0100 article-title: Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(13)70003-6 contributor: fullname: Ngugi – volume: 133 start-page: 1 year: 2013 ident: 10.1016/j.eplepsyres.2017.06.012_bib0065 article-title: Sex-dependent neurotransmitter level changes in brains of Toxoplasma gondii infected mice publication-title: Exp. Parasitol. doi: 10.1016/j.exppara.2012.10.005 contributor: fullname: Gatkowska – volume: 8 start-page: e1003051 year: 2012 ident: 10.1016/j.eplepsyres.2017.06.012_bib0060 article-title: GABAergic signaling is linked to a hypermigratory phenotype in dendritic cells infected by Toxoplasma gondii publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1003051 contributor: fullname: Fuks – volume: 6 start-page: e01428 year: 2015 ident: 10.1016/j.eplepsyres.2017.06.012_bib0035 article-title: Toxoplasma gondii infections alter GABAergic synapses and signaling in the central nervous system publication-title: MBio doi: 10.1128/mBio.01428-15 contributor: fullname: Brooks – volume: 12 start-page: 107 year: 2003 ident: 10.1016/j.eplepsyres.2017.06.012_bib0150 article-title: Investigation of probable relationship between Toxoplasma gondii and cryptogenic epilepsy publication-title: Seizure doi: 10.1016/S1059-1311(02)00256-X contributor: fullname: Yazar – volume: 216 start-page: 99 year: 2013 ident: 10.1016/j.eplepsyres.2017.06.012_bib0140 article-title: Toxoplasma gondii infection, from predation to schizophrenia: can animal behaviour help us understand human behaviour? publication-title: J. Exp. Biol. doi: 10.1242/jeb.074716 contributor: fullname: Webster – volume: 77 start-page: 1 year: 1998 ident: 10.1016/j.eplepsyres.2017.06.012_bib0045 article-title: Toxoplasmosis of rats: a review, with considerations of their value as an animal model and their possible role in epidemiology publication-title: Vet. Parasitol. doi: 10.1016/S0304-4017(97)00227-6 contributor: fullname: Dubey – volume: 216 start-page: 113 year: 2013 ident: 10.1016/j.eplepsyres.2017.06.012_bib0090 article-title: Toxoplasma gondii infection and behaviour − location, location, location? publication-title: J. Exp. Biol. doi: 10.1242/jeb.074153 contributor: fullname: McConkey – volume: 57 start-page: 105 year: 2010 ident: 10.1016/j.eplepsyres.2017.06.012_bib0055 article-title: Toxoplasmosis as a cause for behaviour disorders?overview of evidence and mechanisms publication-title: Folia Parasitol. (Praha) doi: 10.14411/fp.2010.013 contributor: fullname: Fekadu – volume: 16 start-page: 233 year: 2007 ident: 10.1016/j.eplepsyres.2017.06.012_bib0005 article-title: Epilepsy and seropositivity rates of Toxocara canis and Toxoplasma gondii publication-title: Seizure doi: 10.1016/j.seizure.2006.12.008 contributor: fullname: Akyol – volume: 104 start-page: 6442 year: 2007 ident: 10.1016/j.eplepsyres.2017.06.012_bib0130 article-title: Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0608310104 contributor: fullname: Vyas – volume: 87 start-page: 40 year: 2015 ident: 10.1016/j.eplepsyres.2017.06.012_bib0030 article-title: Effects of sulfamethoxazole-trimethoprim associated to resveratrol on its free form and complexed with 2-hydroxypropyl-beta-cyclodextrin on cytokines levels of mice infected by Toxoplasma gondii publication-title: Microb. Pathog. doi: 10.1016/j.micpath.2015.07.013 contributor: fullname: Bottari – year: 2017 ident: 10.1016/j.eplepsyres.2017.06.012_bib0010 article-title: Contribution of dopamine neurotransmission in proconvulsant effect of Toxoplasma gondii infection in male mice publication-title: J. Neurosci. Res. doi: 10.1002/jnr.24036 contributor: fullname: Babaie – volume: 16 start-page: 256 year: 2017 ident: 10.1016/j.eplepsyres.2017.06.012_bib0015 article-title: Seroepidemiological study of Toxoplasma gondii infection in a population of Iranian epileptic patients publication-title: EXCLI J. contributor: fullname: Babaie – volume: 55 start-page: 958 year: 2014 ident: 10.1016/j.eplepsyres.2017.06.012_bib0020 article-title: An unknown quantity?the worldwide prevalence of epilepsy publication-title: Epilepsia doi: 10.1111/epi.12605 contributor: fullname: Bell – volume: 16 start-page: 657 year: 2007 ident: 10.1016/j.eplepsyres.2017.06.012_bib0105 article-title: Meta-analysis of three case controlled studies and an ecological study into the link between cryptogenic epilepsy and chronic toxoplasmosis infection publication-title: Seizure doi: 10.1016/j.seizure.2007.05.010 contributor: fullname: Palmer – volume: 8 start-page: 554 year: 2015 ident: 10.1016/j.eplepsyres.2017.06.012_bib0135 article-title: T. gondii rhoptry protein ROP18 induces apoptosis of neural cells via endoplasmic reticulum stress pathway publication-title: Parasit. Vectors doi: 10.1186/s13071-015-1103-z contributor: fullname: Wan – volume: 91 start-page: 307 year: 2016 ident: 10.1016/j.eplepsyres.2017.06.012_bib0080 article-title: Anti-NMDA receptor autoantibodies and associated neurobehavioral pathology in mice are dependent on age of first exposure to Toxoplasma gondii publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2016.03.005 contributor: fullname: Kannan – volume: 210 start-page: 526 year: 2014 ident: 10.1016/j.eplepsyres.2017.06.012_bib0125 article-title: Influence of toxoplasmosis on acetylcholinesterase activity, nitric oxide levels and cellular lesion on the brain of mice publication-title: Pathol. Res. Pract. doi: 10.1016/j.prp.2014.04.025 contributor: fullname: Tonin – volume: 6 start-page: e28925 year: 2011 ident: 10.1016/j.eplepsyres.2017.06.012_bib0025 article-title: The distribution of Toxoplasma gondii cysts in the brain of a mouse with latent toxoplasmosis: implications for the behavioral manipulation hypothesis publication-title: PLoS One doi: 10.1371/journal.pone.0028925 contributor: fullname: Berenreiterova – volume: 76 start-page: 158 year: 1973 ident: 10.1016/j.eplepsyres.2017.06.012_bib0070 article-title: Toxoplasmic lymphadenitis in Iran publication-title: J. Trop. Med. Hyg. contributor: fullname: Ghorbani – volume: 32 start-page: 281 year: 1972 ident: 10.1016/j.eplepsyres.2017.06.012_bib0110 article-title: Modification of seizure activity by electrical stimulation II. Motor seizure publication-title: Electroencephalogr. Clin. Neurophysiol. doi: 10.1016/0013-4694(72)90177-0 contributor: fullname: Racine – volume: 9 start-page: e0003525 year: 2015 ident: 10.1016/j.eplepsyres.2017.06.012_bib0095 article-title: Toxoplasmosis and epilepsy–systematic review and meta analysis publication-title: PLoS Negl. Trop Dis. doi: 10.1371/journal.pntd.0003525 contributor: fullname: Ngoungou – volume: 33 start-page: 29 year: 2015 ident: 10.1016/j.eplepsyres.2017.06.012_bib0160 article-title: Effect of toxoplasma gondii infection in female mice on dopamine level in the brain of the male offspring publication-title: Zhongguo. Ji. Sheng. Chong. Xue. Yu. Ji. Sheng. Chong. Bing. Za. Zhi. contributor: fullname: Zhou – start-page: 129 year: 2014 ident: 10.1016/j.eplepsyres.2017.06.012_bib0145 contributor: fullname: Weiss – volume: 31 start-page: 454 year: 2013 ident: 10.1016/j.eplepsyres.2017.06.012_bib0155 article-title: Proteomic study of the hippocampus tissue from rats with chronic Toxoplasma gondii infection publication-title: Zhongguo. Ji. Sheng. Chong. Xue. Yu. Ji. Sheng. Chong. Bing. Za. Zhi. contributor: fullname: Zhou |
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•Toxoplasma gondii has high tendency to excitable cells including neurons.•Male rats were infected by i.p. injection of Toxoplasma gondii... Epilepsy is one of the most common neurologic disorders worldwide with no distinguishable cause in 60% of patients. One-third of the world population has been... |
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SubjectTerms | Animals Disease Models, Animal Epilepsy - pathology Epilepsy - physiopathology Epileptogenesis Kaplan-Meier Estimate Kindling Kindling, Neurologic Male Pentylenetetrazole Random Allocation Rat Rats, Wistar Toxoplasma gondii Toxoplasmosis, Animal - pathology Toxoplasmosis, Animal - physiopathology |
Title | Toxoplasmosis accelerates acquisition of epilepsy in rats undergoing chemical kindling |
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