Losartan reduces the immediate and sustained increases in muscle sympathetic nerve activity after hyperacute intermittent hypoxia

• Published in: Journal of applied physiology (1985) Vol. 122; no. 4; pp. 884 - 892
• Main Authors: Jouett, Noah P., Moralez, Gilbert, Raven, Peter B., Smith, Michael L.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.04.2017
• Subjects: Adult; Angiotensin Receptor Antagonists - therapeutic use; Arterial Pressure - drug effects; Blood pressure; Electrocardiography; Experimental design; Female; Humans; Hypertension; Hypertension - drug therapy; Hypertension - metabolism; Hypertension - physiopathology; Hypoxia; Hypoxia - drug therapy; Hypoxia - metabolism; Losartan - therapeutic use; Male; Muscles - drug effects; Muscles - innervation; Muscles - metabolism; Muscular system; Musculoskeletal Physiological Phenomena - drug effects; Receptor, Angiotensin, Type 1 - metabolism; Respiration - drug effects; Sleep apnea; Sleep Apnea, Obstructive - metabolism; Sleep Apnea, Obstructive - physiopathology; Sympathetic Nervous System - drug effects; Sympathetic Nervous System - metabolism; Veins & arteries; Young Adult; obstructive sleep apnea; chemoreflex; losartan; Cozaar; angiotensin II

Obstructive sleep apnea (OSA) is characterized by intermittent hypoxemia, which produces elevations in sympathetic nerve activity (SNA) and associated hypertension in experimental models that persist beyond the initial exposure. We tested the hypotheses that angiotensin receptor blockade in humans u...