Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition

• Published in: Nucleic acids research Vol. 52; no. 4; pp. 1909 - 1929
• Main Authors: Beck, Izaak N, Arrowsmith, Tom J, Grobbelaar, Matthew J, Bromley, Elizabeth H C, Marles-Wright, Jon, Blower, Tim R
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 28.02.2024
• Subjects: Nucleic Acid Enzymes

Abstract Mycobacterium tuberculosis, the causative agent of tuberculosis, is a growing threat to global health, with recent efforts towards its eradication being reversed in the wake of the COVID-19 pandemic. Increasing resistance to gyrase-targeting second-line fluoroquinolone antibiotics indicates...