The roles of exercise in bone remodeling and in prevention and treatment of osteoporosis
With a rapid increase in the aging population, osteoporosis has become a global health problem. Although anti-resorption and anabolic drugs are available, osteoporosis cannot be completely cured. Exercise is an economical, efficacious, and safe way to prevent the development of osteoporosis. Recent...
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| Published in | Progress in biophysics and molecular biology Vol. 122; no. 2; pp. 122 - 130 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.11.2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0079-6107 1873-1732 1873-1732 |
| DOI | 10.1016/j.pbiomolbio.2015.11.005 |
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| Abstract | With a rapid increase in the aging population, osteoporosis has become a global health problem. Although anti-resorption and anabolic drugs are available, osteoporosis cannot be completely cured. Exercise is an economical, efficacious, and safe way to prevent the development of osteoporosis. Recent studies have investigated the mechanisms by which exercise affects bone remodeling. Here we update the progress made on the effects of exercise on bone cells, including bone marrow mesenchymal stem cells, osteoblasts, osteocytes, and osteoclasts, as well as on bone mass, bone strength, and geometry, hoping to provide a theoretical basis to improve osteoporosis prevention and treatment with exercise. |
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| AbstractList | With a rapid increase in the aging population, osteoporosis has become a global health problem. Although anti-resorption and anabolic drugs are available, osteoporosis cannot be completely cured. Exercise is an economical, efficacious, and safe way to prevent the development of osteoporosis. Recent studies have investigated the mechanisms by which exercise affects bone remodeling. Here we update the progress made on the effects of exercise on bone cells, including bone marrow mesenchymal stem cells, osteoblasts, osteocytes, and osteoclasts, as well as on bone mass, bone strength, and geometry, hoping to provide a theoretical basis to improve osteoporosis prevention and treatment with exercise. With a rapid increase in the aging population, osteoporosis has become a global health problem. Although anti-resorption and anabolic drugs are available, osteoporosis cannot be completely cured. Exercise is an economical, efficacious, and safe way to prevent the development of osteoporosis. Recent studies have investigated the mechanisms by which exercise affects bone remodeling. Here we update the progress made on the effects of exercise on bone cells, including bone marrow mesenchymal stem cells, osteoblasts, osteocytes, and osteoclasts, as well as on bone mass, bone strength, and geometry, hoping to provide a theoretical basis to improve osteoporosis prevention and treatment with exercise.With a rapid increase in the aging population, osteoporosis has become a global health problem. Although anti-resorption and anabolic drugs are available, osteoporosis cannot be completely cured. Exercise is an economical, efficacious, and safe way to prevent the development of osteoporosis. Recent studies have investigated the mechanisms by which exercise affects bone remodeling. Here we update the progress made on the effects of exercise on bone cells, including bone marrow mesenchymal stem cells, osteoblasts, osteocytes, and osteoclasts, as well as on bone mass, bone strength, and geometry, hoping to provide a theoretical basis to improve osteoporosis prevention and treatment with exercise. |
| Author | Chen, Xi Chen, Binglin Zhang, Lingli Sun, Zhongguang Yuan, Yu Wu, Juanni Zou, Dongchen Guo, Jianming Shen, Chao Zou, Jun |
| Author_xml | – sequence: 1 givenname: Yu orcidid: 0000-0003-1032-6330 surname: Yuan fullname: Yuan, Yu organization: School of Kinesiology, Shanghai University of Sport, Shanghai, China – sequence: 2 givenname: Xi surname: Chen fullname: Chen, Xi organization: School of Kinesiology, Shanghai University of Sport, Shanghai, China – sequence: 3 givenname: Lingli surname: Zhang fullname: Zhang, Lingli organization: School of Kinesiology, Shanghai University of Sport, Shanghai, China – sequence: 4 givenname: Juanni surname: Wu fullname: Wu, Juanni organization: School of Kinesiology, Shanghai University of Sport, Shanghai, China – sequence: 5 givenname: Jianming surname: Guo fullname: Guo, Jianming organization: School of Kinesiology, Shanghai University of Sport, Shanghai, China – sequence: 6 givenname: Dongchen surname: Zou fullname: Zou, Dongchen organization: Shanghai Foreign Language School, Shanghai, China – sequence: 7 givenname: Binglin surname: Chen fullname: Chen, Binglin organization: School of Kinesiology, Shanghai University of Sport, Shanghai, China – sequence: 8 givenname: Zhongguang surname: Sun fullname: Sun, Zhongguang organization: School of Kinesiology, Shanghai University of Sport, Shanghai, China – sequence: 9 givenname: Chao surname: Shen fullname: Shen, Chao organization: School of Kinesiology, Shanghai University of Sport, Shanghai, China – sequence: 10 givenname: Jun surname: Zou fullname: Zou, Jun email: zoujun777@126.com organization: School of Kinesiology, Shanghai University of Sport, Shanghai, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26657214$$D View this record in MEDLINE/PubMed |
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| Keywords | Osteoporosis Exercise Mechanical loading Osteocytes Osteoclasts Osteoblasts Mesenchymal stem cells |
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| Snippet | With a rapid increase in the aging population, osteoporosis has become a global health problem. Although anti-resorption and anabolic drugs are available,... |
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| SubjectTerms | Animals Bone and Bones - pathology Bone and Bones - physiopathology Bone Remodeling Exercise Humans Mechanical loading Mesenchymal stem cells Osteoblasts Osteoclasts Osteocytes Osteoporosis Osteoporosis - pathology Osteoporosis - physiopathology Osteoporosis - prevention & control Osteoporosis - therapy |
| Title | The roles of exercise in bone remodeling and in prevention and treatment of osteoporosis |
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