FOCAD/miR-491-5p, downregulated by EGR1, function as tumor suppressor by inhibiting the proliferation and migration of gastric cancer cells

• Published in: Progress in biophysics and molecular biology Vol. 176; pp. 25 - 37
• Main Authors: Sun, Ruifang, Liu, Zhigang, Lv, Yun, Yang, Yanqi, Yang, Yang, Xiang, Yu, Jiang, Qiuyu, Zhao, Chang'an, Lv, Moqi, Zhang, Jian, Zhang, Juan, Ding, Caixia, Zhou, Dangxia
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2022
• Subjects: Apoptosis; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation - genetics; Early Growth Response Protein 1 - genetics; Early Growth Response Protein 1 - metabolism; EGR1; Focadhesin; Gastric adenocarcinoma; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; MicroRNAs - genetics; MicroRNAs - metabolism; Migration; Proliferation; Stomach Neoplasms - genetics; Stomach Neoplasms - pathology; Tumor Suppressor Proteins - metabolism; Focadhesin; EGR1; Gastric adenocarcinoma; Proliferation; Migration; Apoptosis

Gastric cancer is a common malignant tumor in China; however, its carcinogenesis remains unknown. Focadhesin (FOCAD) is a tumor suppressor gene in gliomas, its expression, role, and mechanism in gastric cancer have not been defined. The aim of the present study was to explore the expression pattern...