The therapeutic potential of Nrf2 inducers in chronic pain: Evidence from preclinical studies

• Published in: Pharmacology & therapeutics (Oxford) Vol. 225; p. 107846
• Main Authors: Zhou, Ya-Qun, Mei, Wei, Tian, Xue-Bi, Tian, Yu-Ke, Liu, Dai-Qiang, Ye, Da-Wei
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.09.2021
• Subjects: Analgesics - pharmacology; Animals; Chronic pain; Chronic Pain - drug therapy; HO-1; Mice; Mitochondrial function; NF-E2-Related Factor 2 - pharmacology; Nrf2; Oxidative stress; Reactive Oxygen Species; TNFα; AMPA; PT; MDA; NF-κB; MitoQ; STZ; iNOS; TFL; SnPP; MSCA; i.g; PWL; i.p; CoPP; IL-1β; MAPK; PWT; Chronic pain; IL-6; i.t; PPARγ; Maf; ARE; nNOS; ROS; GABA; CFA; Oxidative stress; NO; cGMP; HO-1; LDC; SNI; SNL; PLN; Mitochondrial function; Nrf2; PLR; NMDA; SNT; GSH; NQO1; CCI; PGC-1α; SOD2; GCL; DRG; Keap1

Chronic pain remains an enormous health problem affecting approximatively 30% of the world's population. Opioids as the first line analgesics often leads to undesirable side effects when used long term. Therefore, novel therapeutic targets are urgently needed to the development of more efficaci...