Pharmacokinetics and pharmacodynamics of linezolid in obese patients with cellulitis

• Published in: The Annals of pharmacotherapy Vol. 39; no. 3; p. 427
• Main Authors: Stein, Gary E, Schooley, Sharon L, Peloquin, Charles A, Kak, Vivek, Havlichek, Daniel H, Citron, Diane M, Tyrrell, Kerin L, Goldstein, Ellie J C
• Format: Journal Article
• Language: English
• Published: United States 01.03.2005
• Subjects: Acetamides - pharmacokinetics; Acetamides - pharmacology; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - pharmacology; Area Under Curve; Cellulitis - complications; Cellulitis - drug therapy; Cellulitis - microbiology; Drug Resistance, Multiple, Bacterial; Female; Half-Life; Humans; Linezolid; Male; Microbial Sensitivity Tests; Middle Aged; Obesity - complications; Oxazolidinones - pharmacokinetics; Oxazolidinones - pharmacology; Serum Bactericidal Test; Skin Diseases, Bacterial - complications; Skin Diseases, Bacterial - drug therapy; Skin Diseases, Bacterial - microbiology; Soft Tissue Infections - complications; Soft Tissue Infections - drug therapy; Soft Tissue Infections - microbiology

Linezolid is an oxazolidinone antimicrobial with excellent oral bioavailability and tissue penetration and is active against multidrug-resistant skin/soft tissue pathogens. To study the pharmacokinetics and antibacterial activity of linezolid against selective skin/soft tissue pathogens in obese pat...