Coumarin-azasugar-benzyl conjugates as non-neurotoxic dual inhibitors of butyrylcholinesterase and cancer cell growth

• Published in: Organic & biomolecular chemistry Vol. 22; no. 17; pp. 3425 - 3438
• Main Authors: Vaaland Holmgard, I. Caroline, González-Bakker, Aday, Poeta, Eleonora, Puerta, Adrián, Fernandes, Miguel X, Monti, Barbara, Fernández-Bolaños, José G, Padrón, José M, López, Óscar, Lindbäck, Emil
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 01.05.2024; Royal Society of Chemistry
• Subjects: Acetylcholinesterase; Alkynes; Alzheimer's disease; Anticancer properties; Cerebellum; Chemistry; Chemistry, Organic; Cholinesterase; Cholinesterase inhibitors; Colon cancer; Conjugates; Coumarin; Cycloaddition; Galantamine; Granule cells; Inhibitors; Kemi; Neurodegenerative diseases; Neurotoxicity; Phthalimide; Phthalimides; Physical Sciences; Science & Technology; PATHWAYS; BETA-AMYLOID AGGREGATION; E2020 ARICEPT(R); ACETYLCHOLINESTERASE; ALZHEIMERS-DISEASE; IMINOSUGARS; BINDING; CYTOTOXICITY; DERIVATIVES; RESIDUES

We have applied the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction to prepare a library of ten coumarin-azasugar-benzyl conjugates and two phthalimide-azasugar-benzyl conjugates with potential anti-Alzheimer and anti-cancer properties. The compounds were evaluated as cholinesterase inh...