Bacterial extracellular vesicles and their interplay with the immune system

• Published in: Pharmacology & therapeutics (Oxford) Vol. 247; p. 108443
• Main Authors: Doré, Etienne, Boilard, Eric
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.07.2023
• Subjects: Animals; Bacteria; Bacterial extracellular vesicle; Extracellular Vesicles; Humans; Immune System; Immunity; Mammals; Microbiota; Mucous Membrane; Toll-like receptor; sRNA; CNF1; MHC; IBD; Immunity; TNF; EGFR; LPS; IFN; CFS; PRR; Microbiota; bEV; MNV; Gadd45α; O-IMV; TLR; Toll-like receptor; PSA; IL; TRAIL; AMP; DSS; PBMC; TA; alum; Bacterial extracellular vesicle; HEK; RA; PAMP; PAD; LTA; TGFβ; OMV; OVA; NET; Ig

The mammalian intestinal tract harbors trillions of microorganisms confined within this space by mucosal barriers. Despite these barriers, bacterial components may still be found elsewhere in the body, even in healthy subjects. Bacteria can release small lipid-bound particles, also named bacterial e...