Bacterial extracellular vesicles and their interplay with the immune system

The mammalian intestinal tract harbors trillions of microorganisms confined within this space by mucosal barriers. Despite these barriers, bacterial components may still be found elsewhere in the body, even in healthy subjects. Bacteria can release small lipid-bound particles, also named bacterial e...

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Published inPharmacology & therapeutics (Oxford) Vol. 247; p. 108443
Main Authors Doré, Etienne, Boilard, Eric
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 01.07.2023
Subjects
Animals
Bacteria
Bacterial extracellular vesicle
Extracellular Vesicles
Humans
Immune System
Immunity
Mammals
Microbiota
Mucous Membrane
Toll-like receptor
sRNA
CNF1
MHC
IBD
Immunity
TNF
EGFR
LPS
IFN
CFS
PRR
Microbiota
bEV
MNV
Gadd45α
O-IMV
TLR
Toll-like receptor
PSA
IL
TRAIL
AMP
DSS
PBMC
TA
alum
Bacterial extracellular vesicle
HEK
RA
PAMP
PAD
LTA
TGFβ
OMV
OVA
NET
Ig
Online AccessGet full text

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Abstract The mammalian intestinal tract harbors trillions of microorganisms confined within this space by mucosal barriers. Despite these barriers, bacterial components may still be found elsewhere in the body, even in healthy subjects. Bacteria can release small lipid-bound particles, also named bacterial extracellular vesicles (bEV). While bacteria themselves cannot normally penetrate the mucosal defense, bEVs may infiltrate the barrier and disseminate throughout the body. The extremely diverse cargo that bEVs can carry, depending on their parent species, strain, and growth conditions, grant them an equally broad potential to interact with host cells and influence immune functions. Herein, we review the current knowledge of processes underlying the uptake of bEVs by mammalian cells, and their effect on the immune system. Furthermore, we discuss how bEVs could be targeted and manipulated for diverse therapeutic purposes.
AbstractList The mammalian intestinal tract harbors trillions of microorganisms confined within this space by mucosal barriers. Despite these barriers, bacterial components may still be found elsewhere in the body, even in healthy subjects. Bacteria can release small lipid-bound particles, also named bacterial extracellular vesicles (bEV). While bacteria themselves cannot normally penetrate the mucosal defense, bEVs may infiltrate the barrier and disseminate throughout the body. The extremely diverse cargo that bEVs can carry, depending on their parent species, strain, and growth conditions, grant them an equally broad potential to interact with host cells and influence immune functions. Herein, we review the current knowledge of processes underlying the uptake of bEVs by mammalian cells, and their effect on the immune system. Furthermore, we discuss how bEVs could be targeted and manipulated for diverse therapeutic purposes.The mammalian intestinal tract harbors trillions of microorganisms confined within this space by mucosal barriers. Despite these barriers, bacterial components may still be found elsewhere in the body, even in healthy subjects. Bacteria can release small lipid-bound particles, also named bacterial extracellular vesicles (bEV). While bacteria themselves cannot normally penetrate the mucosal defense, bEVs may infiltrate the barrier and disseminate throughout the body. The extremely diverse cargo that bEVs can carry, depending on their parent species, strain, and growth conditions, grant them an equally broad potential to interact with host cells and influence immune functions. Herein, we review the current knowledge of processes underlying the uptake of bEVs by mammalian cells, and their effect on the immune system. Furthermore, we discuss how bEVs could be targeted and manipulated for diverse therapeutic purposes.
The mammalian intestinal tract harbors trillions of microorganisms confined within this space by mucosal barriers. Despite these barriers, bacterial components may still be found elsewhere in the body, even in healthy subjects. Bacteria can release small lipid-bound particles, also named bacterial extracellular vesicles (bEV). While bacteria themselves cannot normally penetrate the mucosal defense, bEVs may infiltrate the barrier and disseminate throughout the body. The extremely diverse cargo that bEVs can carry, depending on their parent species, strain, and growth conditions, grant them an equally broad potential to interact with host cells and influence immune functions. Herein, we review the current knowledge of processes underlying the uptake of bEVs by mammalian cells, and their effect on the immune system. Furthermore, we discuss how bEVs could be targeted and manipulated for diverse therapeutic purposes.
ArticleNumber 108443
Author Doré, Etienne
Boilard, Eric
Author_xml – sequence: 1
  givenname: Etienne
  surname: Doré
  fullname: Doré, Etienne
  organization: Centre de Recherche du Centre Hospitalier Universitaire de Québec - Université Laval, Québec, QC, Canada
– sequence: 2
  givenname: Eric
  surname: Boilard
  fullname: Boilard, Eric
  email: Eric.Boilard@crchudequebec.ulaval.ca
  organization: Centre de Recherche du Centre Hospitalier Universitaire de Québec - Université Laval, Québec, QC, Canada
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37210006$$D View this record in MEDLINE/PubMed
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Keywords sRNA
CNF1
MHC
IBD
Immunity
TNF
EGFR
LPS
IFN
CFS
PRR
Microbiota
bEV
MNV
Gadd45α
O-IMV
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IL
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TA
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RA
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OVA
NET
Ig
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Snippet The mammalian intestinal tract harbors trillions of microorganisms confined within this space by mucosal barriers. Despite these barriers, bacterial components...
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SubjectTerms Animals
Bacteria
Bacterial extracellular vesicle
Extracellular Vesicles
Humans
Immune System
Immunity
Mammals
Microbiota
Mucous Membrane
Toll-like receptor
Title Bacterial extracellular vesicles and their interplay with the immune system
URI https://dx.doi.org/10.1016/j.pharmthera.2023.108443
https://www.ncbi.nlm.nih.gov/pubmed/37210006
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