The shared role of cholesterol in neuronal and peripheral inflammation

• Published in: Pharmacology & therapeutics (Oxford) Vol. 249; p. 108486
• Main Authors: Hansen, Scott B., Wang, Hao
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.09.2023
• Subjects: Alzheimer's; ApoE; Apolipoprotein; Cholesterol; Lipid rafts; Neuroinflammation; PIP2; Neuroinflammation; ApoE; Lipid rafts; Apolipoprotein; PIP2; Cholesterol; Alzheimer's

Neurodegeneration and its loss of cognitive function is associated with inflammation and an accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of chronic inflammation. In this perspective, we describe the cellular and molecular roles of cholesterol in neuroi...