Water-in-Oil-Only Adjuvants Selectively Promote T Follicular Helper Cell Polarization through a Type I IFN and IL-6-Dependent Pathway

• Published in: The Journal of immunology (1950) Vol. 197; no. 10; pp. 3884 - 3893
• Main Authors: Riteau, Nicolas, Radtke, Andrea J, Shenderov, Kevin, Mittereder, Lara, Oland, Sandra D, Hieny, Sara, Jankovic, Dragana, Sher, Alan
• Format: Journal Article
• Language: English
• Published: United States 15.11.2016
• Subjects: Adjuvants, Immunologic - chemistry; Animals; Antigens - immunology; Cell Differentiation; Germinal Center - immunology; Immunity, Humoral; Immunization; Interferon Type I - immunology; Interferon Type I - metabolism; Interleukin-6 - immunology; Interleukin-6 - metabolism; Lymphocyte Activation; Mice; Oils; Peptides - immunology; Receptors, CXCR5 - metabolism; Signal Transduction; T-Lymphocytes, Helper-Inducer - immunology; Water

T follicular helper (Tfh) cells are a subset of CD4 T lymphocytes that promote the development of humoral immunity. Although the triggers required for the differentiation of the other major Th subsets are well defined, those responsible for Tfh cell responses are still poorly understood. We determin...