Water-in-Oil-Only Adjuvants Selectively Promote T Follicular Helper Cell Polarization through a Type I IFN and IL-6-Dependent Pathway

T follicular helper (Tfh) cells are a subset of CD4 T lymphocytes that promote the development of humoral immunity. Although the triggers required for the differentiation of the other major Th subsets are well defined, those responsible for Tfh cell responses are still poorly understood. We determin...

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Published inThe Journal of immunology (1950) Vol. 197; no. 10; pp. 3884 - 3893
Main Authors Riteau, Nicolas, Radtke, Andrea J, Shenderov, Kevin, Mittereder, Lara, Oland, Sandra D, Hieny, Sara, Jankovic, Dragana, Sher, Alan
Format Journal Article
LanguageEnglish
Published United States 15.11.2016
Subjects
Adjuvants, Immunologic - chemistry
Animals
Antigens - immunology
Cell Differentiation
Germinal Center - immunology
Immunity, Humoral
Immunization
Interferon Type I - immunology
Interferon Type I - metabolism
Interleukin-6 - immunology
Interleukin-6 - metabolism
Lymphocyte Activation
Mice
Oils
Peptides - immunology
Receptors, CXCR5 - metabolism
Signal Transduction
T-Lymphocytes, Helper-Inducer - immunology
Water
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Abstract T follicular helper (Tfh) cells are a subset of CD4 T lymphocytes that promote the development of humoral immunity. Although the triggers required for the differentiation of the other major Th subsets are well defined, those responsible for Tfh cell responses are still poorly understood. We determined that mice immunized with peptide or protein Ags emulsified in IFA or related water-in-oil adjuvants develop a highly polarized response in which the majority of the Ag-specific CD4 T cells are germinal center-homing CXCR5 Bcl6 Tfh cells. Despite the absence of exogenous microbial pathogen-associated molecular patterns, the Tfh cell responses observed were dependent, in part, on MyD88. Importantly, in addition to IL-6, T cell-intrinsic type I IFN signaling is required for optimal Tfh cell polarization. These findings suggest that water-in-oil adjuvants promote Tfh cell-dominated responses by triggering endogenous alarm signals that, in turn, induce type I IFN-dependent differentiation pathway functioning in T cells.
AbstractList T follicular helper (Tfh) cells are a subset of CD4+ T lymphocytes that promote the development of humoral immunity. Although the triggers required for the differentiation of the other major Th subsets are well defined, those responsible for Tfh cell responses are still poorly understood. We determined that mice immunized with peptide or protein Ags emulsified in IFA or related water-in-oil adjuvants develop a highly polarized response in which the majority of the Ag-specific CD4+ T cells are germinal center–homing CXCR5+Bcl6+ Tfh cells. Despite the absence of exogenous microbial pathogen-associated molecular patterns, the Tfh cell responses observed were dependent, in part, on MyD88. Importantly, in addition to IL-6, T cell–intrinsic type I IFN signaling is required for optimal Tfh cell polarization. These findings suggest that water-in-oil adjuvants promote Tfh cell–dominated responses by triggering endogenous alarm signals that, in turn, induce type I IFN–dependent differentiation pathway functioning in T cells.
T follicular helper (Tfh) cells are a subset of CD4 T lymphocytes that promote the development of humoral immunity. Although the triggers required for the differentiation of the other major Th subsets are well defined, those responsible for Tfh cell responses are still poorly understood. We determined that mice immunized with peptide or protein Ags emulsified in IFA or related water-in-oil adjuvants develop a highly polarized response in which the majority of the Ag-specific CD4 T cells are germinal center-homing CXCR5 Bcl6 Tfh cells. Despite the absence of exogenous microbial pathogen-associated molecular patterns, the Tfh cell responses observed were dependent, in part, on MyD88. Importantly, in addition to IL-6, T cell-intrinsic type I IFN signaling is required for optimal Tfh cell polarization. These findings suggest that water-in-oil adjuvants promote Tfh cell-dominated responses by triggering endogenous alarm signals that, in turn, induce type I IFN-dependent differentiation pathway functioning in T cells.
Author Shenderov, Kevin
Radtke, Andrea J
Hieny, Sara
Mittereder, Lara
Riteau, Nicolas
Jankovic, Dragana
Oland, Sandra D
Sher, Alan
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Snippet T follicular helper (Tfh) cells are a subset of CD4 T lymphocytes that promote the development of humoral immunity. Although the triggers required for the...
T follicular helper (Tfh) cells are a subset of CD4+ T lymphocytes that promote the development of humoral immunity. Although the triggers required for the...
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SubjectTerms Adjuvants, Immunologic - chemistry
Animals
Antigens - immunology
Cell Differentiation
Germinal Center - immunology
Immunity, Humoral
Immunization
Interferon Type I - immunology
Interferon Type I - metabolism
Interleukin-6 - immunology
Interleukin-6 - metabolism
Lymphocyte Activation
Mice
Oils
Peptides - immunology
Receptors, CXCR5 - metabolism
Signal Transduction
T-Lymphocytes, Helper-Inducer - immunology
Water
Title Water-in-Oil-Only Adjuvants Selectively Promote T Follicular Helper Cell Polarization through a Type I IFN and IL-6-Dependent Pathway
URI https://www.ncbi.nlm.nih.gov/pubmed/27798160
https://search.proquest.com/docview/1834996322
https://search.proquest.com/docview/1846407393
Volume 197
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