Development and Evolution of a Variable Left–Right Asymmetry in Nematodes: The Handedness of P11/P12 Migration

In Caenorhabditis elegans, two lateral blast cells called P(11/12)L and P(11/12)R are symmetric left–right homologs at hatching, migrate subsequently in opposite anteroposterior directions during the first larval stage, and adopt two different fates, thus breaking the symmetry between them. Our resu...

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Published inDevelopmental biology Vol. 232; no. 2; pp. 362 - 371
Main Authors Delattre, Marie, Félix, Marie-Anne
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.04.2001
Elsevier
Subjects
Animals
Biological Evolution
Body Patterning - genetics
Caenorhabditis elegans - cytology
Caenorhabditis elegans - genetics
Caenorhabditis elegans - growth & development
Cell Communication - genetics
cell lineage
Cell Movement - genetics
evolution
handedness
left–right asymmetry
Life Sciences
LIN-12/Notch
Mutation
Nematoda - cytology
Nematoda - genetics
Nematoda - growth & development
nematodes
P11/P12
Species Specificity
left–right asymmetry
cell lineage
LIN-12/Notch
handedness
evolution
P11/P12
nematodes
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Abstract In Caenorhabditis elegans, two lateral blast cells called P(11/12)L and P(11/12)R are symmetric left–right homologs at hatching, migrate subsequently in opposite anteroposterior directions during the first larval stage, and adopt two different fates, thus breaking the symmetry between them. Our results show that, unlike most other cell fate decisions in C. elegans, the orientation of P(11/12)L/R migration is highly biased, but not fixed. The handedness of their migration is linked to whole body handedness and is randomized in lin-12/Notch mutants and by ablation of the Y cell. Migration handedness is independent of P11 and P12 fate determination, previously shown to require the LIN-44/Wnt and the LIN-3/EGF pathways (L. I. Jiang and P. W. Sternberg, 1998, Development 125, 2337–2347). We further show that several changes in P(11/12)L/R asymmetry have occurred during nematode evolution: loss of asymmetry or reversals in orientation of migration. Strikingly, for most species studied, handedness of migration is highly biased but not fixed. Thus, whereas the final cell fate pattern of P11/12 is invariant, the developmental route leading to it is subject both to developmental indeterminacy and to evolutionary variations.
AbstractList In Caenorhabditis elegans, two lateral blast cells called P11/12L and P11/12R are symmetric left-right homologs at hatching, migrate subsequently in opposite anteroposterior directions during the first larval stage, and adopt two different fates, thus breaking the symmetry between them. Our results show that, unlike most other cell fate decisions in C. elegans, the orientation of P11/12L/R migration is highly biased, but not fixed. The handedness of their migration is linked to whole body handedness and is randomized in lin-12/Notch mutants and by ablation of the Y cell. Migration handedness is independent of P11 and P12 fate determination, previously shown to require the LIN-44/Wnt and the LIN-3/EGF pathways (L. I. Jiang and P. W. Sternberg, 1998, Development 125, 2337-2347). We further show that several changes in P11/12L/R asymmetry have occurred during nematode evolution: loss of asymmetry or reversals in orientation of migration. Strikingly, for most species studied, handedness of migration is highly biased but not fixed. Thus, whereas the final cell fate pattern of P11/12 is invariant, the developmental route leading to it is subject both to developmental indeterminacy and to evolutionary variations.In Caenorhabditis elegans, two lateral blast cells called P11/12L and P11/12R are symmetric left-right homologs at hatching, migrate subsequently in opposite anteroposterior directions during the first larval stage, and adopt two different fates, thus breaking the symmetry between them. Our results show that, unlike most other cell fate decisions in C. elegans, the orientation of P11/12L/R migration is highly biased, but not fixed. The handedness of their migration is linked to whole body handedness and is randomized in lin-12/Notch mutants and by ablation of the Y cell. Migration handedness is independent of P11 and P12 fate determination, previously shown to require the LIN-44/Wnt and the LIN-3/EGF pathways (L. I. Jiang and P. W. Sternberg, 1998, Development 125, 2337-2347). We further show that several changes in P11/12L/R asymmetry have occurred during nematode evolution: loss of asymmetry or reversals in orientation of migration. Strikingly, for most species studied, handedness of migration is highly biased but not fixed. Thus, whereas the final cell fate pattern of P11/12 is invariant, the developmental route leading to it is subject both to developmental indeterminacy and to evolutionary variations.
In Caenorhabditis elegans, two lateral blast cells called P(11/12)L and P(11/12)R are symmetric left–right homologs at hatching, migrate subsequently in opposite anteroposterior directions during the first larval stage, and adopt two different fates, thus breaking the symmetry between them. Our results show that, unlike most other cell fate decisions in C. elegans, the orientation of P(11/12)L/R migration is highly biased, but not fixed. The handedness of their migration is linked to whole body handedness and is randomized in lin-12/Notch mutants and by ablation of the Y cell. Migration handedness is independent of P11 and P12 fate determination, previously shown to require the LIN-44/Wnt and the LIN-3/EGF pathways (L. I. Jiang and P. W. Sternberg, 1998, Development 125, 2337–2347). We further show that several changes in P(11/12)L/R asymmetry have occurred during nematode evolution: loss of asymmetry or reversals in orientation of migration. Strikingly, for most species studied, handedness of migration is highly biased but not fixed. Thus, whereas the final cell fate pattern of P11/12 is invariant, the developmental route leading to it is subject both to developmental indeterminacy and to evolutionary variations.
In Caenorhabditis elegans, two lateral blast cells called P11/12L and P11/12R are symmetric left-right homologs at hatching, migrate subsequently in opposite anteroposterior directions during the first larval stage, and adopt two different fates, thus breaking the symmetry between them. Our results show that, unlike most other cell fate decisions in C. elegans, the orientation of P11/12L/R migration is highly biased, but not fixed. The handedness of their migration is linked to whole body handedness and is randomized in lin-12/Notch mutants and by ablation of the Y cell. Migration handedness is independent of P11 and P12 fate determination, previously shown to require the LIN-44/Wnt and the LIN-3/EGF pathways (L. I. Jiang and P. W. Sternberg, 1998, Development 125, 2337-2347). We further show that several changes in P11/12L/R asymmetry have occurred during nematode evolution: loss of asymmetry or reversals in orientation of migration. Strikingly, for most species studied, handedness of migration is highly biased but not fixed. Thus, whereas the final cell fate pattern of P11/12 is invariant, the developmental route leading to it is subject both to developmental indeterminacy and to evolutionary variations.
Author Delattre, Marie
Félix, Marie-Anne
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Issue 2
Keywords left–right asymmetry
cell lineage
LIN-12/Notch
handedness
evolution
P11/P12
nematodes
Language English
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SSID ssj0003883
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Snippet In Caenorhabditis elegans, two lateral blast cells called P(11/12)L and P(11/12)R are symmetric left–right homologs at hatching, migrate subsequently in...
In Caenorhabditis elegans, two lateral blast cells called P11/12L and P11/12R are symmetric left-right homologs at hatching, migrate subsequently in opposite...
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StartPage 362
SubjectTerms Animals
Biological Evolution
Body Patterning - genetics
Caenorhabditis elegans - cytology
Caenorhabditis elegans - genetics
Caenorhabditis elegans - growth & development
Cell Communication - genetics
cell lineage
Cell Movement - genetics
evolution
handedness
left–right asymmetry
Life Sciences
LIN-12/Notch
Mutation
Nematoda - cytology
Nematoda - genetics
Nematoda - growth & development
nematodes
P11/P12
Species Specificity
Title Development and Evolution of a Variable Left–Right Asymmetry in Nematodes: The Handedness of P11/P12 Migration
URI https://dx.doi.org/10.1006/dbio.2001.0175
https://www.ncbi.nlm.nih.gov/pubmed/11401398
https://www.proquest.com/docview/70948560
https://hal.science/hal-04873585
Volume 232
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