Binge-eating disorder: Clinical and therapeutic advances

• Published in: Pharmacology & therapeutics (Oxford) Vol. 182; pp. 15 - 27
• Main Authors: Hutson, Peter H., Balodis, Iris M., Potenza, Marc N.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.02.2018
• Subjects: Animals; Binge-eating disorder; Binge-Eating Disorder - diagnostic imaging; Binge-Eating Disorder - drug therapy; Binge-Eating Disorder - psychology; Brain - diagnostic imaging; Brain - drug effects; Compulsivity; Disease Models, Animal; Humans; Impulsivity; Neurobiology; Pharmacotherapy; Reward; ADHD; FDA; FAAH; Binge-eating disorder; Neurobiology; MIDT; Pharmacotherapy; CNS; IFG; BN; PFC; OFC; SPECT; YBOCS-BE; DSM 5; NMDA; BOLD; MAGL; BMI; BED; rCBF; LDX; Impulsivity; TRPV; NOP; PPARs; Compulsivity; fMRI; PCC; GMV; SSRI; tDCS; dlPFC; 2-AG; CB1 and CB2; PG; GABA; TAAR; OX1 and OX2; Reward; 5-HT; PET

Binge-eating disorder (BED) is the most prevalent eating disorder with estimates of 2–5% of the general adult population. Nonetheless, its pathophysiology is poorly understood. Furthermore, there exist few therapeutic options for its effective treatment. Here we review the current state of binge-eat...