Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor

• Published in: Chinese journal of oceanology and limnology Vol. 28; no. 1; pp. 96 - 98
• Main Author: 史大永 李晓红 李敬 郭书举 苏华 范晓
• Format: Journal Article
• Language: English
• Published: Heidelberg SP Science Press 2010; Springer Nature B.V
• Subjects: Algae; Benzofuran; Cardiovascular disease; Cardiovascular diseases; Coagulation; Disease prophylaxis; Earth and Environmental Science; Earth Sciences; Enzymes; Ferric chloride; Inhibitors; Leathesia nana; Oceanography; Pharmacology; Prophylaxis; Proteinase; Proteinase inhibitors; Thrombin; Thromboembolism; Thrombosis; 凝血酶抑制剂; 心血管疾病; 抗血栓; 苯并呋喃; 血栓性疾病; 衍生物; thrombin inhibitor; bromophenol derivative; antithrombotic effect

Thrombin, the ultimate proteinase of the coagulation cascade, is an attractive target for the treatment of a variety of cardiovascular diseases. A bromophenol derivative named （＋）-3-（2,3-dibromo-4, 5-dihydroxy-phenyl）-4-bromo-5,6-dihydroxy-1,3-dihydroiso-benzofuran 1, isolated from the brown alga Le...