In vitro study of the expression of autophagy genes ATG101, mTOR and AMPK in breast cancer with treatment of lactoferrin and in silico study of their communication networks and protein interactions

• Published in: Progress in biophysics and molecular biology Vol. 190; pp. 19 - 27
• Main Authors: Mashhadi Kholerdi, Atefeh, Moradian, Fatemeh, Mehralitabar, Havva
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2024
• Subjects: AMP-Activated Protein Kinases - metabolism; Autophagy - drug effects; Autophagy genes; Autophagy-Related Proteins - genetics; Autophagy-Related Proteins - metabolism; Breast cancer cell; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Computer Simulation; Docking; Gene Expression Regulation, Neoplastic - drug effects; Humans; In silico; Lactoferrin; Lactoferrin - metabolism; Lactoferrin - pharmacology; MCF-7 Cells; Protein Binding; Protein Interaction Maps - drug effects; TOR Serine-Threonine Kinases - metabolism; Breast cancer cell; Docking; In silico; Lactoferrin; Autophagy genes

Autophagy is a new window of science that has been noticed due to the importance of specific therapies in cancer. In this study, the effect of lactoferrin (Lf) on the expression level of ATG101, mTOR and AMPK genes in breast cancer cell line MCF7, as well as the interaction between lactoferrin prote...