Interaction between Erythrocyte Phospholipid Fatty Acids Composition and Variants of Inflammation-Related Genes on Type 2 Diabetes

• Published in: Journal of nutrigenetics and nutrigenomics Vol. 7; no. 4-6; pp. 252 - 263
• Main Authors: Li, Kelei, Huang, Tao, Zheng, Ju-Sheng, Sun, Jianqin, Chen, Yanqiu, Xie, Hua, Xu, Danfeng, Wan, Jianbo, Li, Duo
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.01.2014
• Subjects: Adult; Aged; Asian Continental Ancestry Group - genetics; Case-Control Studies; China; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; Erythrocytes - metabolism; Fatty Acids - blood; Female; Genotype; Granulocyte Colony-Stimulating Factor - genetics; Hepatocyte Nuclear Factor 1-alpha - genetics; Humans; Male; Middle Aged; Nutrigenomics; Original Paper; Phospholipids - blood; Polymorphism, Single Nucleotide; Proteasome Endopeptidase Complex - genetics; Risk Factors; China; Inflammation; Type 2 diabetes mellitus; Single nucleotide polymorphism; Polyunsaturated fatty acids
• ISSN: 2504-3161; 2504-3188; 1661-6758
• DOI: 10.1159/000381347

Aims: The present study aimed to investigate the interaction between erythrocyte phospholipid (PL) fatty acids and variants of inflammation-related genes in a Chinese population. Methods: A total of 622 patients with type 2 diabetes mellitus (T2DM) and 293 healthy subjects were included. Determination of erythrocyte PL fatty acids composition and genotyping of single nucleotide polymorphisms were conducted by standard methods. Results: A significant interaction of rs7305618 on HNFIA with C18:2n-6 and C20:4n-6 was observed: T allele carriers (TT + CT) had a higher risk of T2DM than noncarriers only when they had a higher level of C18:2n-6 or C20:4n-6, and the odds ratios (ORs) were 2.59 (95% CI 1.58-4.24; p for interaction = 0.005) and 2.49 (95% CI 1.47-4.24; p for interaction = 0.021), respectively. A significant interaction of rs8078723 at the intergenic region between PSMD3 and CSF3 with C20:5n-3 was observed: C allele carriers (CC + CT) had a lower risk of T2DM than noncarriers only when they had a higher level of C20:5n-3, and the OR was 0.44 (95% CI 0.26-0.73; p for interaction = 0.014). Conclusions: rs7305618 and rs8078723 were associated with the risk of T2DM in a Chinese population and were modulated by erythrocyte PL fatty acids composition.