Signal transducer and activator of transcription 3 signaling in tumor immune evasion

• Published in: Pharmacology & therapeutics (Oxford) Vol. 230; p. 107969
• Main Authors: Zhang, Luying, Kuca, Kamil, You, Li, Zhao, Yingying, Musilek, Kamil, Nepovimova, Eugenie, Wu, Qinghua, Wu, Wenda, Adam, Vojtech
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.02.2022
• Subjects: Animals; Cell Line, Tumor; Humans; Hypoxia; Immune evasion; lncRNA; Signal Transduction; STAT3; STAT3 Transcription Factor - metabolism; Tumor Escape; Tumor Microenvironment; lncRNAs; VEGFR2; lncRNA; GDEs; HIF-1α; HIFs; PKD3; CXCL-10; S1P; TAMs; Th; DCs; CCL5; GSC; PGRN; PD-L1; PD-L2; MM; CD; PGE2; IL; Tumor microenvironment; Tregs; STAT3; Bcl; Immune evasion; EMT; FOXP3; TME; HMBOX1/SOCS1; MDSCs; SLTCL; Bregs; Mcl; miR; Hypoxia; NK; PD-1; BMSCs; FGFR2; B7-H4; IDO1

The underlying mechanism of tumor immune evasion is a highly concerning subject for researchers. Increasing evidences reveal that the over-activated signal transducer and activator of transcription 3 (STAT3) is a crucial molecular hub in malignant tumors. STAT3 controls autophagy molecules that impa...