Design, synthesis and evaluation of novel dual monoamine-cholinesterase inhibitors as potential treatment for Alzheimer’s disease

• Published in: Neuropharmacology Vol. 109; pp. 376 - 385
• Main Authors: Liu, Wei, Lang, Ming, Youdim, Moussa B.H., Amit, Tamar, Sun, Yewei, Zhang, Zaijun, Wang, Yuqiang, Weinreb, Orly
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2016
• Subjects: Alzheimer Disease - drug therapy; Alzheimer Disease - metabolism; Alzheimer’s disease; Animals; Brain - drug effects; Brain - metabolism; Cell Line, Tumor; Cholinesterase inhibition; Cholinesterase Inhibitors - administration & dosage; Cholinesterase Inhibitors - chemical synthesis; Dose-Response Relationship, Drug; Drug Combinations; Drug Design; Humans; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors - administration & dosage; Monoamine Oxidase Inhibitors - chemical synthesis; Monoamine oxidase-A inhibition; Multifunctional drug; Neuroprotection; Rats; Rats, Sprague-Dawley; Treatment Outcome; Neuroprotection; AChE; ChE; AChEIs; AD; BBB; Alzheimer’s disease; DOPAC; OS; ACh; Multifunctional drug; HVA; Cholinesterase inhibition; 5-HIAA; Monoamine oxidase-A inhibition; 3-MT; NE; ROS; MAO; 5-HT; DA; HPLC

Current novel therapeutic approach suggests that multifunctional compounds with diverse biological properties and a single bioavailability and pharmacokinetic metabolism, will produce higher significant advantages in treatment of neurodegenerative diseases, such as Alzheimer’s disease (AD). Based on...