Understanding the Dual Nature of CD44 in Breast Cancer Progression

• Published in: Molecular cancer research Vol. 9; no. 12; pp. 1573 - 1586
• Main Authors: Louderbough, Jeanne M.V., Schroeder, Joyce A.
• Format: Journal Article
• Language: English
• Published: United States 01.12.2011
• Subjects: Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Transformation, Neoplastic - genetics; Disease Progression; Female; Genes, Tumor Suppressor; Humans; Hyaluronan Receptors - chemistry; Hyaluronan Receptors - genetics; Hyaluronan Receptors - metabolism; Neoplasm Metastasis; Neoplastic Stem Cells; Signal Transduction

CD44 has been the subject of extensive research for more than 3 decades because of its role in breast cancer, in addition to many physiological processes, but interestingly, conflicting data implicate CD44 in both tumor suppression and tumor promotion. CD44 has been shown to promote protumorigenic s...